Inenzymology, alow-density-lipoprotein receptor kinase (EC2.7.11.29) is anenzyme thatcatalyzes thechemical reaction

ATP + [low-density-lipoprotein receptor]-L-serine${\displaystyle \rightleftharpoons }$ ADP + [low-density-lipoprotein receptor]-O-phospho-L-serine

Thus, the twosubstrates of this enzyme areATP and [[[low-density-lipoprotein receptor]-L-serine]], whereas its twoproducts areADP and [[[low-density-lipoprotein receptor]-O-phospho-L-serine]].

This enzyme belongs to the family oftransferases, specifically those transferring a phosphate group to the sidechainoxygen atom ofserine orthreonine residues inproteins (protein-serine/threonine kinases). Thesystematic name of this enzyme class isATP:[low-density-lipoprotein receptor]-L-serine O-phosphotransferase. Other names in common use includeATP:low-density-lipoprotein-L-serine O-phosphotransferase,LDL receptor kinase,[low-density-lipoprotein] kinase,low-density lipoprotein kinase,low-density-lipoprotein receptor kinase (phosphorylating), andSTK7.

• Kishimoto A, Brown MS, Slaughter CA, Goldstein JL (1987)."Phosphorylation of serine 833 in cytoplasmic domain of low density lipoprotein receptor by a high molecular weight enzyme resembling casein kinase II".J. Biol. Chem.262 (3):1344–51.doi:10.1016/S0021-9258(19)75792-5.PMID 3100530.
• Kishimoto A, Goldstein JL, Brown MS (1987)."Purification of catalytic subunit of low density lipoprotein receptor kinase and identification of heat-stable activator protein".J. Biol. Chem.262 (19):9367–73.doi:10.1016/S0021-9258(18)48089-1.PMID 3597414.

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