Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

Lorajmine

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Lorajmine
Clinical data
ATC code
Identifiers
  • (17R,21β)-ajmalan-17,21-diol 17-chloroacetate
    OR
    (1R,9R,10S,13R,14R,16S,18S)-13-ethyl-8-methyl-14-hydroxy-8,15-diazahexacyclo [14.2.1.01,9.02,7.010,15.012,17]nonadeca-2(7),3,5-triene-18-yl chloroacetate
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
ECHA InfoCard100.051.185Edit this at Wikidata
Chemical and physical data
FormulaC22H27ClN2O3
Molar mass402.92 g·mol−1
3D model (JSmol)
  • CCC1C2CC3C4C5(CC(C2C5C(=O)OCCl)N3C1O)C6=CC=CC=C6N4C
  • InChI=1S/C22H27ClN2O3/c1-3-11-12-8-15-19-22(13-6-4-5-7-14(13)24(19)2)9-16(25(15)21(11)27)18(12)20(22)28-17(26)10-23/h4-7,11-12,15-16,18-21,27H,3,8-10H2,1-2H3/t11-,12-,15-,16-,18?,19-,20+,21+,22+/m0/s1 checkY
  • Key:LAHDERDHXJFFJU-KBFYUGGWSA-N checkY
  (verify)

Lorajmine (17-monochloroacetylajmaline) is adrug that is a potentsodium channel blocker (more specifically, a class Iaantiarrhythmic agent) that was used for treatingarrhythmia.[1][2][3] It is derived from ajmaline, analkaloid from the roots ofRauvolfia serpentina, by synthetically adding achloroacetate residue.

References

[edit]
  1. ^Medical Dictionary Online: Lorajmine
  2. ^World Health Organization:ATC/DDD Index
  3. ^Sanna G, Meoli P, Bianchini C, Rovelli F (1983). "Antiarrhythmic effectiveness of propafenone compared to lorajmine in ventricular arrhythmias. Controlled clinical trial".Giornale Italiano di Cardiologia.13 (3):145–51.PMID 6350090.
Channel blockers
class I
(Na+ channel blockers)
class Ia (Phase 0→ andPhase 3→)
class Ib (Phase 3←)
class Ic (Phase 0→)
class III
(Phase 3→,K+ channel blockers)
class IV
(Phase 4→,Ca2+ channel blockers)
Receptoragonists
andantagonists
class II
(Phase 4→,β blockers)
A1 agonist
M2
α receptors
Ion transporters
Na+/ K+-ATPase


Stub icon

Thisdrug article relating to thecardiovascular system is astub. You can help Wikipedia byadding missing information.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Lorajmine&oldid=1332190509"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2026 Movatter.jp