| Artist(s) | Single | Peak | Peak date |
|---|
| Mika | "Rain" | 6 | 16 January |
| Kesha | "Tik Tok" | 1 | 16 January |
| Lady Gaga | "Bad Romance" | 2 | 23 January |
| Christophe Maé | "Dingue, dingue, dingue" | 7 | 30 January |
| Jay-Z featuringAlicia Keys | "Empire State of Mind" | 3 | 30 January |
| Artists for Haiti | "We Are the World 25 for Haiti" | 7 | 20 February |
| Muse | "Uprising" | 10 | 27 February |
| Joyce Jonathan | "Pas besoin de toi" | 6 | 27 February |
| Stromae | "Alors on danse" | 1 | 27 February |
| David Guetta featuringKid Cudi | "Memories" | 4 | 6 March |
| Rihanna | "Rude Boy" | 2 | 6 March |
| Cœur de pirate andJulien Doré | "Pour un infidèle" | 6 | 13 March |
| Les Enfoirés | "Si l'on s'aimait, si" | 5 | 20 March |
| Iyaz | "Replay" | 3 | 20 March |
| Black Eyed Peas | "Rock That Body" | 9 | 27 March |
| L'Algérino | "Sur la tête de ma mère" | 7 | 27 March |
| Cheryl Cole | "Fight for This Love" | 6 | 27 March |
| Christophe Maé | "J'ai laissé" | 2 | 27 March |
| Géraldine Nakache andLeïla Bekhti | "Chanson sur une drôle de vie" | 9 | 3 April |
| Camélia Jordana | "Non non non (Écouter Barbara)" | 3 | 3 April |
| Lady Gaga featuringBeyonce | "Telephone" | 2 | 3 April |
| Justin Bieber featuringLudacris | "Baby" | 9 | 10 April |
| Owl City | "Fireflies" | 7 | 17 April |
| Edward Maya featuringVika Jigulina | "This Is My Life" | 5 | 17 April |
| Sexion d'Assaut | "Désolé" | 1 | 17 April |
| Remady | "No Superstar" | 6 | 24 April |
| Sean Paul featuringZaho | "Hold My Hand" | 3 | 1 May |
| Taio Cruz | "Break Your Heart" | 2 | 1 May |
| Gnarls Barkley | "Going On" | 8 | 8 May |
| Sexion d'Assaut | "Wati By Night" | 6 | 8 May |
| Inna | "Hot" | 5 | 15 May |
| Timbaland featuringKaty Perry | "If We Ever Meet Again" | 4 | 15 May |
| Gaëtan Roussel | "Help Myself (Nous ne faisons que passer)" | 9 | 22 May |
| Plan B | "She Said" | 5 | 22 May |
| Train | "Hey, Soul Sister" | 10 | 5 June |
| Rihanna | "Te Amo" | 8 | 12 June |
| David Guetta andChris Willis featuringFergie andLMFAO | "Gettin' Over You" | 6 | 12 June |
| Lady Gaga | "Alejandro" | 3 | 12 June |
| Shy'm | "Je sais" | 3 | 19 June |
| Shakira featuringFreshlyground | "Waka Waka (This Time for Africa)" | 1 | 19 June |
| Zaz | "Je veux" | 3 | 26 June |
| K'naan andFéfé | "Wavin' Flag" | 3 | 10 July |
| Enrique Iglesias featuringPitbull | "I Like It" | 9 | 17 July |
| Katy Perry featuringSnoop Dogg | "California Gurls" | 3 | 17 July |
| Fatal Bazooka | "Ce matin va être une pure soirée" | 4 | 24 July |
| Inna | "Amazing" | 4 | 31 July |
| René la Taupe | "Mignon Mignon" | 1 | 14 August |
| Yolanda Be Cool andDCUP | "We No Speak Americano" | 1 | 4 September |
| Katy Perry | "Teenage Dream" | 6 | 11 September |
| Eminem featuringRihanna | "Love the Way You Lie" | 1 | 11 September |
| Flo Rida featuringDavid Guetta | "Club Can't Handle Me" | 5 | 18 September |
| Mohombi | "Bumpy Ride" | 4 | 25 September |
| Taio Cruz | "Dynamite" | 3 | 25 September |
| B.o.B featuringHayley Williams | "Airplanes" | 7 | 2 October |
| Rihanna | "Only Girl (In the World)" | 1 | 2 October |
| Soprano | "Hiro" | 2 | 9 October |
| Julian Perretta | "Wonder Why" | 6 | 16 October |
| Mylène Farmer | "Oui mais... non" | 1 | 16 October |
| Usher featuringPitbull | "DJ Got Us Fallin' in Love" | 3 | 23 October |
| Shakira featuringDizzee Rascal | "Loca" | 1 | 23 October |
| Martin Solveig featuringDragonette | "Hello" | 6 | 6 November |
| Guillaume Grand | "Toi et moi" | 5 | 6 November |
| Duck Sauce | "Barbra Streisand" | 3 | 6 November |
| Mister You | "Les p'tits de chez moi" | 10 | 13 November |
| Mike Posner | "Cooler than Me" | 6 | 13 November |
| Black Eyed Peas | "The Time (Dirty Bit)" | 1 | 20 November |
| Taio Cruz featuringKylie Minogue | "Higher" | 9 | 27 November |
| David Guetta featuringRihanna | "Who's That Chick?" | 5 | 27 November |
| Rihanna featuringDrake | "What's My Name?" | 5 | 11 December |
| Israel Kamakawiwo'ole | "Over the Rainbow" | 4 | 18 December |
| Katy Perry | "Firework" | 5 | 25 December |
