| Rank | Name | Image | City | Height ft / m | Floors | Year | Note | Reference |
|---|
| 1 | Davenport Bank and Trust |  | Davenport | 255 / 78 | 17 | 1927 | Tallest building in the Quad Cities | [1][2][3] |
| 2 | MidAmerican Building |  | Davenport | 220 / 66 | 15 | 1995 | Second tallest building in the Quad Cities; tallest building constructed in the Quad Cities in the 1990s. | [4][3] |
| 3 | Kone Tower |  | Moline | 180 / 55 | 16 | 1966 | Elevator testing building (inactive). Set to be demolished. | [5][3] |
| 4 | LeClaire Apartments |  | Moline | 168 / 51 | 15 | 1922 | Tallest building in the Quad Cities 1922-1927 | [6][3] |
| 5 | Sacred Heart Cathedral |  | Davenport | 160 / 49 | | 1891 | Tallest Building in the Quad Cities 1891-1922 | [7][8] |
| 6 | Kahl Building/Capitol Theater |  | Davenport | 146 / 44 | 10 | 1919 | | [9][3] |
| 7 | US Bank Building |  | Davenport | 144 / 44 | 10 | 1923 | | [10][3] |
| 8 | Northwest Bank NorthPark Tower |  | Davenport | 143 / 44 | 10 | 1974 | Tallest building constructed in the Quad Cities in the 1970s | [11][3] |
| 9 | Hotel Blackhawk |  | Davenport | 140 / 42 | 11 | 1915 | | [12][3] |
| 10 | KONE Centre |  | Moline | 134 / 41 | 8 | 2012 | Tallest building constructed in the Quad Cities in the 2010s; tallest building built since 1995. | [13][3] |
| 11 | Steepmeadow Condominiums |  | Rock Island | 131 / 40 | 12 | 1962 | Tallest residential-only building in the Quad Cities | [14][3][15] |
| 11 | Trinity Episcopal Cathedral |  | Davenport | 131 / 40 | | 1873/1998 | | [16][8] |
| 11 | Mississippi Lofts |  | Davenport | 131 / 40 | 10 | 1931 | | [17][18] |
| 14 | Summit Ridge Condominiums |  | East Moline | 130 / 40 | 12 | 1970 | | [19][3] |
| 15 | Putnam Building |  | Davenport | 126 / 38 | 8 | 1910 | | [20][3] |
| 16 | Union Arcade Building |  | Davenport | 125 / 38 | 7 | 1924 | | [21][3] |