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List of psychedelic drugs

From Wikipedia, the free encyclopedia

Part ofa series on
Psychedelia

This is a list ofpsychedelic drugs, also known as serotonergic psychedelics or classical hallucinogens.[1][2] These drugs act specifically asserotonin5-HT2A receptoragonists.[3] They belong to three major structural families, including thetryptamines,phenethylamines, andlysergamides, although exceptions exist.[4][5][6][7]

Tryptamines

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Main article:Substituted tryptamine

No ring substitutions

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4-Hydroxytryptamines

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Main article:Substituted 4-hydroxytryptamine

4-Phosphoryloxytryptamines

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4-Acyloxytryptamines

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5-Hydroxytryptamines

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Main article:Substituted 5-hydroxytryptamine

5-Acyloxytryptamines

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5-Methoxytryptamines

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Main article:Substituted 5-methoxytryptamine

Other ring substitutions

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α-Alkyltryptamines

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Main article:Substituted α-alkyltryptamine

5-Methoxy-α-alkyltryptamines

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Others

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Structure undisclosed

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Cyclized tryptamines

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Main article:Cyclized tryptamine

Tryptamine bioisosteres

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Main article:Substituted tryptamine § Related compounds

Phenethylamines

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Main article:Substituted phenethylamine

Scalines

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Main article:Scaline

Thioscalines

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2C-x

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Main article:2C (psychedelics)

2C-T-x

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2C-O-x

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Others

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3C-x

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Main article:3C (psychedelics)

DOx

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Main article:DOx (psychedelics)

Aleph-x (DOT-x)

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TMA-2 and derivatives (Mxx)

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Others

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4C-x

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Main article:4C (psychedelics)

Ψ-PEA

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Main article:Ψ-PEA (psychedelics)

MDxx

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Main article:Substituted methylenedioxyphenethylamine

FLY

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Main article:FLY (psychedelics)

Hemi/semi-FLY drugs

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25x-NB (NBOMes)

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Main article:25-NB (psychedelics)

25x-NBOMe

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25x-NBOH

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Others

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Others

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Structure undisclosed

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Cyclized phenethylamines

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Main article:Cyclized phenethylamine

Lysergamides

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Main article:Substituted lysergamide

No substitutions

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Amide-substituted lysergamides

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6-Alkyllysergamides

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1-Alkyllysergamides (prodrugs)

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1-Acyllysergamides (prodrugs)

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Others

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Lysergamide bioisosteres

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Others

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See also:List of miscellaneous 5-HT2A receptor agonists

Structure undisclosed

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Natural sources

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Main article:List of psychoactive plants, fungi, and animals

Tryptamines

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Phenethylamines

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Lysergamides

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See also

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References

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  1. ^Nichols DE (February 2004). "Hallucinogens".Pharmacol Ther.101 (2):131–181.doi:10.1016/j.pharmthera.2003.11.002.PMID 14761703.
  2. ^Nichols DE (April 2016)."Psychedelics".Pharmacol Rev.68 (2):264–355.doi:10.1124/pr.115.011478.PMC 4813425.PMID 26841800.
  3. ^Gumpper RH, Nichols DE (October 2024). "Chemistry/structural biology of psychedelic drugs and their receptor(s)".Br J Pharmacol.doi:10.1111/bph.17361.PMID 39354889.
  4. ^abShulgin, Alexander;Shulgin, Ann (September 1997).TiHKAL: The Continuation.Berkeley, California:Transform Press.ISBN 0-9630096-9-9.OCLC 38503252.
  5. ^Shulgin, Alexander;Shulgin, Ann (September 1991).PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press.ISBN 0-9630096-0-5.OCLC 25627628.
  6. ^Trachsel, D.; Lehmann, D.; Enzensperger, C. (2013).Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag.ISBN 978-3-03788-700-4.OCLC 858805226. Archived fromthe original on 21 August 2025.
  7. ^Nichols DE (2018). "Chemistry and Structure-Activity Relationships of Psychedelics".Curr Top Behav Neurosci.36:1–43.doi:10.1007/7854_2017_475.PMID 28401524.
  8. ^Martin WR, Sloan JW (1970). "Effects of infused tryptamine in man".Psychopharmacologia.18 (3):231–237.doi:10.1007/BF00412669.PMID 4922520.
Tryptamines
No ring subs.
4-Hydroxytryptamines
5-Hydroxytryptamines
5-Methoxytryptamines
Other ring subs.
α-Alkyltryptamines
Others
Cyclized
Bioisosteres
Phenethylamines
Scalines
2C-x
3C-x
DOx
4C-x
Ψ-PEA
MDxx
FLY
25x-NB (NBOMes)
Others
Cyclized
Lysergamides
Others
Natural sources
5-HT1
5-HT1A
5-HT1B
5-HT1D
5-HT1E
5-HT1F
5-HT2
5-HT2A
5-HT2B
5-HT2C
5-HT37
5-HT3
5-HT4
5-HT5A
5-HT6
5-HT7
Tryptamines
4-Hydroxytryptamines
andesters/ethers
5-Hydroxy- and
5-methoxytryptamines
N-Acetyltryptamines
α-Alkyltryptamines
α-Ketotryptamines
Cyclized tryptamines
Isotryptamines
Related compounds
Phenethylamines
Amphetamines
Phentermines
Cathinones
Phenylisobutylamines
(and further-extended)
Catecholamines
(and close relatives)
Cyclized
phenethylamines
Phenylalkylpyrrolidines
2-Benzylpiperidines
(phenidates)
Phenylmorpholines
(phenmetrazines)
Phenyloxazolamines
(aminorexes)
Isoquinolines and
tetrahydroisoquinolines
2-Aminoindanes
2-Aminotetralins
Others / unsorted
Related compounds
Ergolines
(incl.lysergines)
Clavines
(6,8-dimethylergolines)
Lysergamides
(lysergic acid amides)
Ergopeptines
(peptide ergolines)
Partial ergolines
Related compounds
Natural sources
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