| Debut year | Player name | Position | Debut NFL/AFL team | Notes |
|---|
| 1943 | Bob Thurbon | RB | Phil-Pitt Steagles | Played 20 games for the Steagles andCard-Pitt between the1943 and1944 NFL seasons, and 2 games for theBuffalo Bisons during the1946 AAFC season |
| 1955 | John Reger | LB | Pittsburgh Steelers | Played 144 games for the Steelers andWashington Redskins between the1955 and1966 NFL seasons |
| 1965 | Fred Mazurek | WR | Washington Redskins | Played 13 games for the Redskins between the1965 and1966 NFL seasons |
| 1973 | Ron Holliday | WR | San Diego Chargers | Played 11 games for the Chargers during the1973 NFL season |
| 1976 | Glenn Hyde | T | Denver Broncos | Played 115 games for the Broncos,Baltimore Colts,Seattle Seahawks, andKansas City Chiefs between the1976 and1987 NFL seasons |
| 1977 | Cecil Johnson | LB | Tampa Bay Buccaneers | Played 111 games for the Buccaneers between the1977 and1985 NFL seasons |
| 1981 | David Trout | K | Pittsburgh Steelers | Played 19 games for the Steelers during the1981 and1987 NFL seasons |
| 1985 | Greg Christy | T | Buffalo Bills | Played 7 games for the Bills during the1985 NFL season |
| 1986 | Tony Brown | T | New England Patriots | Played 2 games for theBuffalo Bills during the1987 NFL season |
| 1987 | Steve Apke | LB | Pittsburgh Steelers | Played 3 games for the Steelers during the1987 NFL season |
| 1990 | Tony Siragusa | DT | Indianapolis Colts | Played 169 games for the Colts andBaltimore Ravens between the1990 and2001 NFL seasons |
| 1992 | Don Silvestri | K | Seattle Seahawks | Played 28 games for theNew York Jets between the1995 and1996 NFL seasons |
| 1993 | Vernon Lewis | DB | New England Patriots | Played 44 games for the Patriots between the1993 and1996 NFL seasons |
| 1995 | Billy Davis | WR | Dallas Cowboys | Played 93 games for the Cowboys andBaltimore Ravens between the1995 and2000 NFL seasons |
| 1999 | Matt Lytle | QB | Carolina Panthers | Played 5 games for the Panthers andSeattle Seahawks between the2000 and2001 NFL seasons |
| 2000 | Darnell Dinkins | TE | New York Giants | Played 89 games for the Giants,Baltimore Ravens,Cleveland Browns, andNew Orleans Saints between the2002 and2009 NFL seasons |
| 2001 | Nick Goings | RB | Carolina Panthers | Played 105 games for the Panthers between the2001 and2008 NFL seasons |
| 2004 | Lousaka Polite | FB | Dallas Cowboys | Played 82 games for the Cowboys,Chicago Bears,Miami Dolphins,New England Patriots, andAtlanta Falcons between the2004 and2012 NFL seasons |
| 2007 | Tyler Palko | QB | New Orleans Saints | Played 8 games for theKansas City Chiefs between the2010 and2011 NFL seasons |
| 2009 | C. J. Davis | G | Carolina Panthers | Played 14 games for the Panthers andDenver Broncos between the2010 and2012 NFL seasons |
| 2011 | Henry Hynoski | FB | New York Giants | Played 46 games for the Giants between the2011 and2014 NFL seasons |
| 2012 | Lucas Nix | G | Oakland Raiders | Played 15 games for the Raiders between the2012 and2013 NFL seasons |
| 2014 | K'Waun Williams | DB | Cleveland Browns | Played 105 games for the Browns,San Francisco 49ers, andDenver Broncos between the2014 and2022 NFL seasons |
| 2016 | Nicholas Grigsby | LB | Los Angeles Rams | Played 23 games for the Rams,New England Patriots, andDetroit Lions between the2016 and2018 NFL seasons |
| J. P. Holtz | TE | Cleveland Browns | Played 51 games for theWashington Redskins,Chicago Bears, andNew Orleans Saints between the2019 and2023 NFL seasons |
| Lafayette Pitts | DB | Miami Dolphins | Played 40 games for the Dolphins,Jacksonville Jaguars, andBuffalo Bills between the2016 and2018 NFL seasons |
| 2017 | Ryan Lewis | DB | Arizona Cardinals | Played 25 games for theBuffalo Bills,Indianapolis Colts,Philadelphia Eagles,Miami Dolphins andNew York Giants between the2018 and2020 NFL seasons |
| 2021 | D. J. Turner | WR | Las Vegas Raiders | Played 32 games for the Raiders between the2022 and2025 NFL seasons |
| 2022 | Cal Adomitis | LS | Cincinnati Bengals | Played 58 games for the Bengals andPhiladelphia Eagles between the2022 and2025 NFL seasons |
| Lucas Krull | TE | New Orleans Saints | Played 24 games for the Saints andDenver Broncos between the2022 and2025 NFL seasons |
| 2023 | Jared Wayne | WR | Houston Texans | Played 4 games for the Texans between the2024 and2025 NFL season |
| 2025 | Donovan McMillon | DB | Cleveland Browns | Played 17 games for the Browns during the2025 NFL season |
| Ben Sauls | K | Pittsburgh Steelers | Played 3 games for theNew York Giants during the2025 NFL season |
