| Refuge Name | Location | State | Date Established | Area |
|---|
| Bon Secour National Wildlife Refuge[5] | Baldwin County | AL | 1980 | 6,816 acres (27.58 km2) |
| Cahaba River National Wildlife Refuge | Bibb County | AL | September 25, 2002 | 2,997 acres (12.13 km2)[6] |
| Choctaw National Wildlife Refuge | Choctaw County | AL | 1964 | 4,218 acres (17.07 km2) |
| Eufaula National Wildlife Refuge | Barbour County, Alabama Stewart County, Georgia | AL | 1964 | 11,184 acres (45.26 km2)[7] |
| Fern Cave National Wildlife Refuge | Jackson County | AL | 1981 | 199 acres (0.81 km2) |
| Key Cave National Wildlife Refuge | Lauderdale County | AL | January 3, 1997 | 1,060 acres (4.3 km2)[8] |
| Mountain Longleaf National Wildlife Refuge | Calhoun County | AL | May 29, 2003 | 9,016 acres (36.49 km2) |
| Sauta Cave National Wildlife Refuge | Jackson County | AL | 1978 | 264 acres (1.07 km2) |
| Watercress Darter National Wildlife Refuge | Jefferson County | AL | 1980 | 24 acres (0.097 km2) |
| Wheeler National Wildlife Refuge | Morgan County,Limestone County, and Madison County | AL | 1938 | 35,000 acres (140 km2)[9] |
| Alaska Maritime National Wildlife Refuge | Alaska | AK | December 2, 1980[10] | 3,421,420 acres (13,846.0 km2) |
| Alaska Peninsula National Wildlife Refuge | Alaska | AK | December 2, 1980 | 3,574,259 acres (14,464.51 km2) |
| Arctic National Wildlife Refuge | Alaska | AK | December 6, 1960[11] | 19,287,042 acres (78,051.89 km2) |
| Becharof National Wildlife Refuge | Alaska | AK | December 2, 1980[12] | 1,200,419.52 acres (4,857.9254 km2) |
| Innoko National Wildlife Refuge | Alaska | AK | December 2, 1980[13] | 3,850,800.94 acres (15,583.6385 km2) |
| Izembek National Wildlife Refuge | Alaska | AK | December 2, 1980[14] | 315,000 acres (1,270 km2) |
| Kanuti National Wildlife Refuge | Alaska | AK | December 2, 1980[15] | 1,637,000 acres (6,620 km2) |
| Kenai National Wildlife Refuge | Alaska | AK | December 2, 1980[15] | 1,912,470.47 acres (7,739.4934 km2)[16] |
| Kodiak National Wildlife Refuge | Alaska | AK | August 19, 1941[17] | 1,880,891.52 acres (7,611.6979 km2)[16] |
| Koyukuk National Wildlife Refuge | Alaska | AK | 1980 | 3,550,159.96 acres (14,366.9876 km2)[16] |
| Nowitna National Wildlife Refuge | Alaska | AK | 1980 | 1,560,239.99 acres (6,314.0672 km2)[16] |
| Selawik National Wildlife Refuge | Alaska | AK | December 2, 1980 | 2,150,561.94 acres (8,703.0154 km2)[16] |
| Tetlin National Wildlife Refuge | Alaska | AK | December 2, 1980 | 700,286.95 acres (2,833.9607 km2)[16] |
| Togiak National Wildlife Refuge | Alaska | AK | December 2, 1980 | 4,104,246.80 acres (16,609.2975 km2)[16] |
| Yukon Delta National Wildlife Refuge | Alaska | AK | December 2, 1980 | 19,226,606.25 acres (77,807.3150 km2)[16] |
| Yukon Flats National Wildlife Refuge | Alaska | AK | December 2, 1980 | 8,636,951.06 acres (34,952.5009 km2)[16] |
| Rose Atoll National Wildlife Refuge | Rose Atoll | AS | 1973 | 39,066 acres (158.09 km2)[18] |
| Bill Williams River National Wildlife Refuge | La Paz andMojave Counties | AZ | 1993[19] | 6,105 acres (24.71 km2) |
| Buenos Aires National Wildlife Refuge | Pima County | AZ | 1985 | 117,107 acres (473.92 km2) |
| Cabeza Prieta National Wildlife Refuge | Yuma County | AZ | 1939 | 860,010 acres (3,480.3 km2) |
| Cibola National Wildlife Refuge | LaPaz County, Arizona Imperial County, California | AZ | 1964 | 16,627 acres (67.29 km2) |
| Havasu National Wildlife Refuge | Mojave County, Arizona San Bernardino County, California | AZ | 1941 | 37,515 acres (151.82 km2) |
| Imperial National Wildlife Refuge | LaPaz andYuma Counties, Arizona Imperial County, California | AZ | 1941 | 25,768 acres (104.28 km2)[20] |
| Kofa National Wildlife Refuge | Yuma andLaPaz Counties | AZ | 1939 | 665,400 acres (2,693 km2) |
| Leslie Canyon National Wildlife Refuge | Cochise County | AZ | 1988 | 2,770 acres (11.2 km2) |
| San Bernardino National Wildlife Refuge | Cochise County | AZ | 1982 | 2,309 acres (9.34 km2) |
| Bald Knob National Wildlife Refuge | White County | AR | 1993 | 15,022 acres (60.79 km2)[21] |
| Big Lake National Wildlife Refuge | Mississippi County | AR | 1915 | 11,038 acres (44.67 km2)[22] |
| Cache River National Wildlife Refuge | Woodruff County and several others | AR | 1986 | 67,500 acres (273 km2)[23] |
| Felsenthal National Wildlife Refuge | Union,Ashley, andBradley Counties | AR | 1970 | 64,902 acres (262.65 km2) |
| Holla Bend National Wildlife Refuge | Pope andYell Counties | AR | 1957 | 7,057 acres (28.56 km2)[24] |
| Logan Cave National Wildlife Refuge | Benton County | AR | March 14, 1989 | 123 acres (0.50 km2)[25] |
| Overflow National Wildlife Refuge | Ashley County | AR | 1980 | 13,973 acres (56.55 km2)[26] |
| Pond Creek National Wildlife Refuge | Sevier County | AR | 1994 | 27,300 acres (110 km2) |
| Wapanocca National Wildlife Refuge | Crittenden County | AR | January 1961 | 5,484 acres (22.19 km2) |
| White River National Wildlife Refuge | Monroe County and several others | AR | 1935 | 160,756 acres (650.56 km2) |
| Antioch Dunes National Wildlife Refuge | Contra Costa County | CA | 1980 | 55 acres (0.22 km2)[27] |
| Bitter Creek National Wildlife Refuge | Kern County | CA | 1985 | 14,097 acres (57.05 km2)[28] |
| Blue Ridge National Wildlife Refuge | Tulare County | CA | 1982 | 897 acres (3.63 km2)[29] |
| Butte Sink Wildlife Management Area | Butte/Colusa/Sutter Counties | CA | 1980 | 11,044 acres (44.69 km2)[30] |
| Castle Rock National Wildlife Refuge | Del Norte County | CA | 1979 | 14 acres (0.057 km2)[31] |
| Clear Lake National Wildlife Refuge | Modoc County | CA | 1911 | 46,460 acres (188.0 km2)[32] |
| Coachella Valley National Wildlife Refuge | Riverside County | CA | 1985 | 3,709 acres (15.01 km2)[33] |
| Colusa National Wildlife Refuge | Colusa County | CA | 1945 | 4,507 acres (18.24 km2)[34] |
| Delevan National Wildlife Refuge | Colusa County | CA | 1962 | 5,797 acres (23.46 km2)[35] |
| Don Edwards San Francisco Bay National Wildlife Refuge | Alameda/Santa Clara/San Mateo Counties | CA | 1974 | 30,000 acres (120 km2)[36] |
| Ellicott Slough National Wildlife Refuge | Santa Cruz County | CA | 1975 | 168 acres (0.68 km2)[37] |
| Farallon National Wildlife Refuge | Farallon Islands, nearSan Francisco | CA | 1969 | 41.9 acres (0.170 km2)[38] |
| Grasslands Wildlife Management Area | Merced County | CA | 1979 | 70,000 acres (280 km2)[39] |
| Guadalupe-Nipomo Dunes National Wildlife Refuge | Santa Barbara/San Luis Obispo Counties | CA | 2000 | 2,553 acres (10.33 km2)[40] |
| Hopper Mountain National Wildlife Refuge | Ventura County | CA | 1974 | 2,471 acres (10.00 km2)[41] |
Humboldt Bay National Wildlife Refuge *Lanphere Dunes | Humboldt County | CA | 1971 | 4,000 acres (16 km2)[42] |
| Kern National Wildlife Refuge | Kern County | CA | 1960 | 1,249 acres (5.05 km2)[43] |
| Lower Klamath National Wildlife Refuge | Siskiyou County also inKlamath County, Oregon | CA | 1908 | 50,913 acres (206.04 km2)[44] |
| Marin Islands National Wildlife Refuge | Marin County | CA | 1992[45] | - |
| Merced National Wildlife Refuge | Merced County | CA | 1951 | 10,262 acres (41.53 km2)[46] |
| Modoc National Wildlife Refuge | Modoc County | CA | 1961 | 7,000 acres (28 km2)[47] |
| North Central Valley Wildlife Management Area | Sacramento Valley | CA | 1991 | 46,460 acres (188.0 km2)[48] |
| Pixley National Wildlife Refuge | Tulare County | CA | 1959 | 6,939 acres (28.08 km2)[49] |
| Sacramento National Wildlife Refuge | Colusa/Glenn Counties | CA | 1937 | 10,819 acres (43.78 km2)[50] |
| Sacramento River National Wildlife Refuge | Butte/Glenn/Tehama Counties | CA | 1989 | 10,146 acres (41.06 km2)[51] |
| Salinas River National Wildlife Refuge | Monterey County | CA | 1974 | 316 acres (1.28 km2)[52] |
| San Diego Bay National Wildlife Refuge | San Diego County | CA | 1999 | 2,620 acres (10.6 km2)[53] |
| San Diego National Wildlife Refuge | San Diego County | CA | - | 11,152 acres (45.13 km2)[54] |
| San Joaquin River National Wildlife Refuge | San Joaquin/Stanislaus Counties | CA | 1987 | 7,000 acres (28 km2)[55] |
| San Luis National Wildlife Refuge | Merced County | CA | 1966 | 26,600 acres (108 km2)[56] |
| San Pablo Bay National Wildlife Refuge | Napa/Solano/Sonoma Counties | CA | 1970 | 13,190 acres (53.4 km2)[57] |
| Seal Beach National Wildlife Refuge | Orange County | CA | 1972 | 911 acres (3.69 km2)[58] |
| Sonny Bono Salton Sea National Wildlife Refuge | Imperial County | CA | 1930 | 2,200 acres (8.9 km2)[59] |
| Stone Lakes National Wildlife Refuge | Sacramento County | CA | 1994 | 17,641 acres (71.39 km2)[60] |
| Sutter National Wildlife Refuge | Sutter County | CA | 1945 | 2,591 acres (10.49 km2)[61] |
| Tijuana Slough National Wildlife Refuge | San Diego County | CA | 1980 | 2,521 acres (10.20 km2)[62] |
| Tule Lake National Wildlife Refuge | Modoc/Siskiyou Counties | CA | 1928 | 39,116 acres (158.30 km2)[63] |
| Willow Creek-Lurline Wildlife Management Area | Colusa/Glenn Counties | CA | 1985 | 5,795 acres (23.45 km2)[64] |
| Alamosa National Wildlife Refuge | Alamosa,Conejos andCostilla Counties | CO | 1993 | 11,169 acres (45.20 km2)[65] |
| Arapaho National Wildlife Refuge | Jackson County | CO | 1967 | 23,464 acres (94.96 km2)[66] |
| Baca National Wildlife Refuge | Saguache andAlamosa Counties | CO | 2003 | 78,697 acres (318.48 km2) |
| Browns Park National Wildlife Refuge | Moffat County | CO | 1965 | 12,150 acres (49.2 km2)[67] |
| Monte Vista National Wildlife Refuge | Alamosa andRio Grande Counties | CO | 1953 | 14,800 acres (60 km2)[67] |
| Rocky Flats National Wildlife Refuge | Jefferson County | CO | July 12, 2007 | 3,953 acres (16.00 km2) |
| Rocky Mountain Arsenal National Wildlife Refuge | Adams County | CO | 1992 | 15,988 acres (64.70 km2) |
| Two Ponds National Wildlife Refuge | Jefferson County | CO | 1992 | 72.2 acres (0.292 km2) |
| Stewart B. McKinney National Wildlife Refuge | Connecticut | CT | 1972 | 950 acres (3.8 km2)[68] |
| Bombay Hook National Wildlife Refuge | Kent County | DE | 1937 | 16,251 acres (65.77 km2)[69] |
| Prime Hook National Wildlife Refuge | Sussex County | DE | 1963 | 10,144 acres (41.05 km2)[70] |
| Archie Carr National Wildlife Refuge | Brevard County Indian River County | FL | 1991 | 900 acres (3.6 km2)[71] |
| Arthur R. Marshall Loxahatchee National Wildlife Refuge | Palm Beach County | FL | 1951 | 147,392 acres (596.47 km2)[72] |
| Caloosahatchee National Wildlife Refuge | Lee County | FL | 1921 | 40 acres (0.16 km2)[73] |
| Cedar Keys National Wildlife Refuge | Levy County | FL | 1929 | 891 acres (3.61 km2)[74] |
| Chassahowitzka National Wildlife Refuge | Citrus County Hernando County | FL | 1941 | 31,000 acres (130 km2)[75] |
| Crocodile Lake National Wildlife Refuge | Monroe County | FL | 1980 | 6,686 acres (27.06 km2)[76] |
| Crystal River National Wildlife Refuge | Citrus County | FL | 1983 | 80 acres (0.32 km2)[77] |
| Egmont Key National Wildlife Refuge | Hillsborough County | FL | 1974 | 450 acres (1.8 km2)[78] |
| Everglades Headwaters National Wildlife Refuge and Conservation Area | Hardee County Highlands County Polk County | FL | 1991 | 900 acres (3.6 km2)[79] |
| Florida Panther National Wildlife Refuge | Collier County | FL | 1989 | 26,400 acres (107 km2)[80] |
| Great White Heron National Wildlife Refuge | Monroe County | FL | 1938 | 130,187 acres (526.85 km2)[81] |
| Hobe Sound National Wildlife Refuge | Martin County | FL | 1969 | 1,035 acres (4.19 km2)[82] |
| Island Bay National Wildlife Refuge | Charlotte County | FL | 1908 | 20 acres (0.081 km2)[83] |
| J.N. 'Ding' Darling National Wildlife Refuge | Lee County | FL | 1976 | 5,200 acres (21 km2)[84] |
| Key Deer National Wildlife Refuge | Monroe County | FL | 1957 | 8,542 acres (34.57 km2)[85] |
| Key West National Wildlife Refuge | Monroe County | FL | 1908 | 189,497 acres (766.87 km2)[86] |
| Lake Wales Ridge National Wildlife Refuge | Highlands County Polk County | FL | 1990 | 1,194 acres (4.83 km2)[87] |
| Lake Woodruff National Wildlife Refuge | Lake County Volusia County | FL | 1964 | 21,574 acres (87.31 km2)[88] |
| Lower Suwannee National Wildlife Refuge | Dixie County Levy County | FL | 1979 | 53,000 acres (210 km2)[89] |
| Matlacha Pass National Wildlife Refuge | Lee County | FL | 1908 | 538 acres (2.18 km2)[90] |
| Merritt Island National Wildlife Refuge | Brevard County | FL | 1963 | 140,000 acres (570 km2)[91] |
| Passage Key National Wildlife Refuge | Manatee County | FL | 1905 | 64 acres (0.26 km2)[92] |
| Pelican Island National Wildlife Refuge | Indian River County | FL | 1903-First National Wildlife Refuge in U.S. | 5,376 acres (21.76 km2)[93] |
| Pine Island National Wildlife Refuge | Lee County | FL | 1908 | 601 acres (2.43 km2)[94] |
| Pinellas National Wildlife Refuge | Pinellas County | FL | 1951 | 394 acres (1.59 km2)[95] |
| St. Johns National Wildlife Refuge | Brevard County | FL | 1971 | 6,255 acres (25.31 km2)[96] |
| St. Marks National Wildlife Refuge | Jefferson County Taylor County Wakulla County | FL | 1931 | 68,000 acres (280 km2)[97] |
| St. Vincent National Wildlife Refuge | Franklin County Gulf County | FL | 1968 | 12,490 acres (50.5 km2)[98] |
| Ten Thousand Islands National Wildlife Refuge | Collier County Monroe County | FL | 1996 | 35,000 acres (140 km2)[99] |
| Banks Lake National Wildlife Refuge | Lanier County | GA | 1985 | 4,049 acres (16.39 km2)[100] |
| Blackbeard Island National Wildlife Refuge (Part of theSavannah Coastal Refuges Complex) | McIntosh County | GA | 1924 | 5,618 acres (22.74 km2)[101] |
| Bond Swamp National Wildlife Refuge | Bibb County Twiggs County | GA | 1989 | 6,500 acres (26 km2)[102] |
| Harris Neck National Wildlife Refuge (Part of theSavannah Coastal Refuges Complex) | McIntosh County | GA | 1962 | 2,762 acres (11.18 km2)[103] |
| Okefenokee National Wildlife Refuge | Primarily inCharlton andWare Counties, Georgia andBaker County, Florida | GA | 1937 | 402,000 acres (1,630 km2)[104] |
| Piedmont National Wildlife Refuge | Jasper County Jones County | GA | 1939 | 35,000 acres (140 km2)[105] |
| Savannah National Wildlife Refuge* | Chatham andEffingham Counties, Georgia andJasper County, South Carolina | GA | 1927 | 29,175 acres (118.07 km2)[106] |
| Wassaw National Wildlife Refuge (Part of theSavannah Coastal Refuges Complex) | Chatham County | GA | 1969 | 10,053 acres (40.68 km2)[107] |
| Wolf Island National Wildlife Refuge (Part of theSavannah Coastal Refuges Complex) | McIntosh County | GA | 1930 | 5,126 acres (20.74 km2)[108] |
| Guam National Wildlife Refuge | Guam | GU | 1993 | 1,203 acres (4.87 km2)[109] |
| Hakalau Forest National Wildlife Refuge | Island of Hawaiʻi | HI | 1985 | 38,047 acres (153.97 km2)[110] |
| Hanalei National Wildlife Refuge | Island of Kauaʻi | HI | 1972 | 917 acres (3.71 km2)[111] |
| Hawaiian Islands National Wildlife Refuge | Hawaiʻi | HI | 1909 | 245,000 acres (990 km2)[112] |
| Hulē‘ia National Wildlife Refuge | Island of Kauaʻi | HI | 1973 | 241 acres (0.98 km2)[113] |
| James Campbell National Wildlife Refuge | Island of Oʻahu | HI | 1976 | 1,100 acres (4.5 km2)[114] |
| Kakahai‘a National Wildlife Refuge | Island of Molokaʻi | HI | 1977 | 44 acres (0.18 km2)[115] |
| Kealia Pond National Wildlife Refuge | Island of Maui | HI | 1992 | 700 acres (2.8 km2)[116] |
| Kilauea Point National Wildlife Refuge | Island of Kauaʻi | HI | 1985 | 203 acres (0.82 km2)[117] |
| Oahu Forest National Wildlife Refuge | Island of Oʻahu | HI | 2000 | 4,525 acres (18.31 km2)[118] |
| Pearl Harbor National Wildlife Refuge | Island of Oʻahu | HI | 1972 | 63 acres (0.25 km2)[119] |
| Bear Lake National Wildlife Refuge (Part of theSoutheast Idaho National Wildlife Refuge Complex) | Bear Lake County | ID | 1968 | 19,000 acres (77 km2)[120] |
| Camas National Wildlife Refuge (Part of theSoutheast Idaho National Wildlife Refuge Complex) | Jefferson County | ID | 1937 | 10,578 acres (42.81 km2)[121] |
| Deer Flat National Wildlife Refuge | Canyon County Owyhee County Payette County Washington County Malheur County, Oregon Baker County, Oregon | ID | 1909 | 10,548 acres (42.69 km2)[122] |
| Grays Lake National Wildlife Refuge (Part of theSoutheast Idaho National Wildlife Refuge Complex) | Bonneville County Caribou County | ID | 1965 | 19,400 acres (79 km2)[123] |
| Kootenai National Wildlife Refuge | Boundary County | ID | 1964 | 2,774 acres (11.23 km2)[124] |
| Minidoka National Wildlife Refuge (Part of theSoutheast Idaho National Wildlife Refuge Complex) | Blaine County Cassia County Minidoka County Power County | ID | 1909 | 20,751 acres (83.98 km2)[125] |
| Oxford Slough Waterfowl Production Area | Bannock County Franklin County | ID | 1985 | 1,878 acres (7.60 km2)[126] |
| Chautauqua National Wildlife Refuge | Mason County | IL | 1936 | 4,388 acres (17.76 km2)[127] |
| Crab Orchard National Wildlife Refuge | Jackson County Union County Williamson County | IL | 1947 | 43,890 acres (177.6 km2)[128] |
| Cypress Creek National Wildlife Refuge | Alexander County Johnson County Pulaski County Union County | IL | 1990 | 16,000 acres (65 km2)[129] |
| Emiquon National Wildlife Refuge | Fulton County | IL | 1993 | 11,122 acres (45.01 km2)[130] |
| Hackmatack National Wildlife Refuge | McHenry County Walworth County, Wisconsin | IL | 2012 | 11,200 acres (45 km2)[131] |
| Kankakee National Wildlife Refuge and Conservation Area | Iroquois County | IL | 2016 | 66 acres (0.27 km2)[132] |
| Meredosia National Wildlife Refuge | Cass County Morgan County | IL | 1973 | 5,255 acres (21.27 km2)[133] |
| Middle Mississippi River National Wildlife Refuge | Illinois Missouri | IL | 2000 | 7,000 acres (28 km2)[134] |
| Two Rivers National Wildlife Refuge | Illinois Missouri | IL | 1958 | 8,501 acres (34.40 km2)[135] |
| Big Oaks National Wildlife Refuge | Jefferson County Jennings County Ripley County | IN | 2000 | 50,000 acres (200 km2)[136] |
| Muscatatuck National Wildlife Refuge | Jackson County Jennings County Monroe County | IN | 1966 | 7,880 acres (31.9 km2)[137] |
| Patoka River National Wildlife Refuge and Management Area | Gibson County Pike County | IN | 1994 | 23,962 acres (96.97 km2)[138] |
| DeSoto National Wildlife Refuge | Harrison County Pottawattamie County Washington County, Nebraska | IA | 1958 | 8,362 acres (33.84 km2)[139] |
| Driftless Area National Wildlife Refuge | Iowa Illinois Wisconsin | IA | 1989 | 911 acres (3.69 km2)[140] |
| Iowa Wetland Management District | Covers 15 counties | IA | | 25,000 acres (100 km2) 75 waterfowl production areas[141] |
| Neal Smith National Wildlife Refuge | Jasper County | IA | 1990 | 8,654 acres (35.02 km2)[142] |
| Port Louisa National Wildlife Refuge | Louisa County Mercer County, Illinois | IA | 1958 | 1,078 acres (4.36 km2)[143] |
| Union Slough National Wildlife Refuge | Kossuth County | IA | 1938 | 3,334 acres (13.49 km2)[144] |
| Flint Hills National Wildlife Refuge | Coffey County Lyon County | KS | 1966 | 18,463 acres (74.72 km2)[145] |
| Kirwin National Wildlife Refuge | Phillips County | KS | 1954 | 10,778 acres (43.62 km2)[146] |
| Marais des Cygnes National Wildlife Refuge | Linn County | KS | 1992 | 7,500 acres (30 km2)[147] |
| Quivira National Wildlife Refuge | Reno County Rice County Stafford County | KS | 1955 | 22,135 acres (89.58 km2)[148] |
| Clarks River National Wildlife Refuge | Graves County Marshall County McCracken County | KY | 1997 | 8,040 acres (32.5 km2)[149] |
| Green River National Wildlife Refuge | Henderson County | KY | 2019 | 10 acres (0.040 km2)[150] |
| Atchafalaya National Wildlife Refuge | Iberville Parish St. Martin Parish | LA | 1986 | 15,220 acres (61.6 km2)[151] |
| Bayou Cocodrie National Wildlife Refuge | Concordia Parish | LA | 1992 | 13,200 acres (53 km2)[152] |
| Bayou Sauvage National Wildlife Refuge | New Orleans | LA | 1990 | 22,770 acres (92.1 km2)[153] |
| Bayou Teche National Wildlife Refuge | St. Mary Parish | LA | 2001 | 9,028 acres (36.54 km2)[154] |
| Big Branch Marsh National Wildlife Refuge | St. Tammany Parish | LA | 2001 | 24,000 acres (97 km2)[155] |
| Black Bayou Lake National Wildlife Refuge | Ouachita Parish | LA | 1997 | 4,200 acres (17 km2)[156] |
| Bogue Chitto National Wildlife Refuge | St. Tammany andWashington Parishes, Louisiana andPearl River County, Mississippi | LA | 1980 | 40,000 acres (160 km2)[157] |
| Breton National Wildlife Refuge | St. Bernard Parish Plaquemines Parish | LA | 1904 | 13,000 acres (53 km2)[158] |
| Cameron Prairie National Wildlife Refuge | Cameron Parish | LA | 1986 | 9,621 acres (38.93 km2)[159] |
| Cat Island National Wildlife Refuge | West Feliciana Parish | LA | 2000 | 9,623 acres (38.94 km2)[160] |
| Catahoula National Wildlife Refuge | Catahoula Parish LaSalle Parish | LA | 1958 | 25,162 acres (101.83 km2)[161] |
| D'Arbonne National Wildlife Refuge | Ouachita Parish Union Parish | LA | 1986[162] | - |
| Delta National Wildlife Refuge | Plaquemines Parish | LA | 1935 | 49,000 acres (200 km2)[163] |
| Grand Cote National Wildlife Refuge | Avoyelles Parish | LA | 1989 | 6,077 acres (24.59 km2)[164] |
| East Cove National Wildlife Refuge | Cameron Parish | LA | 1937 | 14,927 acres (60.41 km2)[165] |
| Handy Brake National Wildlife Refuge | Morehouse Parish | LA | 1988 | 501 acres (2.03 km2)[166] |
| Lacassine National Wildlife Refuge | Cameron Parish Evangeline Parish | LA | 1937 | 35,000 acres (140 km2)[167] |
| Lake Ophelia National Wildlife Refuge | Avoyelles Parish | LA | 1988 | 17,500 acres (71 km2)[168] |
| Louisiana Wetland Management District | 20 parishes in northern Louisiana | LA | 1990 | 25,710 acres (104.0 km2)[169] |
| Mandalay National Wildlife Refuge | Terrebonne Parish | LA | 1996 | 4,416 acres (17.87 km2)[170] |
| Red River National Wildlife Refuge | Bossier Parish Caddo Parish DeSoto Parish Natchitoches Parish Red River Parish | LA | 2001 | 50,000 acres (200 km2)[171] |
| Sabine National Wildlife Refuge | Cameron Parish | LA | 1937 | 125,790 acres (509.1 km2)[172] |
| Shell Keys National Wildlife Refuge | Iberia Parish | LA | 1907[173] | - |
| Tensas River National Wildlife Refuge | Franklin Parish Madison Parish Tensas Parish | LA | 1998 | 64,012 acres (259.05 km2)[174] |
| Upper Ouachita National Wildlife Refuge | Morehouse Parish Union Parish | LA | 1978 | 41,430 acres (167.7 km2)[175] |
| Aroostook National Wildlife Refuge | Aroostook County | ME | 1998 | 5,252 acres (21.25 km2)[176] |
| Carlton Pond Waterfowl Production Area | Waldo County | ME | 1966 | 1,055 acres (4.27 km2)[177] |
| Cross Island National Wildlife Refuge (Part ofMaine Coastal Islands National Wildlife Refuge) | Washington County | ME | 1980 | 1,700 acres (6.9 km2)[178] |
| Franklin Island National Wildlife Refuge (Part ofMaine Coastal Islands National Wildlife Refuge) | Knox County | ME | 1973 | 12 acres (0.049 km2)[179] |
| Moosehorn National Wildlife Refuge | Washington County | ME | 1937 | 28,751 acres (116.35 km2)[180] |
| Petit Manan National Wildlife Refuge (Part ofMaine Coastal Islands National Wildlife Refuge) | Hancock County Washington County | ME | 1974 | 6,367 acres (25.77 km2)[181] |
| Pond Island National Wildlife Refuge (Part ofMaine Coastal Islands National Wildlife Refuge) | Sagadahoc County | ME | 1973 | 10 acres (0.040 km2)[182] |
| Rachel Carson National Wildlife Refuge | Cumberland County York County | ME | 1966 | 9,125 acres (36.93 km2)[183] |
| Seal Island National Wildlife Refuge (Part ofMaine Coastal Islands National Wildlife Refuge) | Knox County | ME | 1972 | 65 acres (0.26 km2)[184] |
| Sunkhaze Meadows National Wildlife Refuge | Penobscot County | ME | 1988 | 11,435 acres (46.28 km2)[185] |
| Blackwater National Wildlife Refuge (Part ofChesapeake Marshlands National Wildlife Refuge Complex) | Dorchester County | MD | 1933 | 28,894.35 acres (116.9313 km2)[186] |
| Eastern Neck National Wildlife Refuge (Part ofChesapeake Marshlands National Wildlife Refuge Complex) | Kent County | MD | 1962 | 2,285 acres (9.25 km2)[187] |
| Glenn Martin National Wildlife Refuge (Part ofChesapeake Marshlands National Wildlife Refuge Complex) | Somerset County Accomack County, Virginia | MD | 1954 | 4,548 acres (18.41 km2)[188] |
| Patuxent Research Refuge[1] | Anne Arundel County Prince George's County | MD | 1936 | 12,800 acres (52 km2)[189] |
| Susquehanna River National Wildlife Refuge (Part ofChesapeake Marshlands National Wildlife Refuge Complex) | Harford County | MD | 1944 | 3.79 acres (0.0153 km2)[190] |
| Assabet River National Wildlife Refuge | Sudbury | MA | 2005 | 2,230 acres (9.0 km2)[191] |
| Great Meadows National Wildlife Refuge | Sudbury | MA | 1944 | 250 acres (1.0 km2)[192] |
| Mashpee National Wildlife Refuge | Mashpee | MA | 1995 | 341.65 acres (1.3826 km2)[193] |
| Massasoit National Wildlife Refuge | Plymouth | MA | 1983 | 195 acres (0.79 km2)[194] |
| Monomoy National Wildlife Refuge | Barnstable County | MA | 1944 | 7,604 acres (30.77 km2)[195] |
| Nantucket National Wildlife Refuge | Nantucket | MA | 1973 | 24 acres (0.097 km2)[196] |
| Nomans Land Island National Wildlife Refuge | Nomans Land | MA | 1998 | 640 acres (2.6 km2)[197] |
| Oxbow National Wildlife Refuge | Middlesex County Worcester County | MA | 1974 | 1,667 acres (6.75 km2)[198] |
| Parker River National Wildlife Refuge | Plum Island | MA | 1942 | 4,662 acres (18.87 km2)[199] |
| Silvio O. Conte National Fish and Wildlife Refuge | Massachusetts Connecticut New Hampshire Vermont | MA | 1997 | 31,216 acres (126.33 km2)[200] |
| Thacher Island National Wildlife Refuge | Thacher Island | MA | 1972 | 22 acres (0.089 km2)[201] |
| Detroit River International Wildlife Refuge | Detroit River Lake Erie | MI | 2001 | 5,868 acres (23.75 km2)[202] |
| Harbor Island National Wildlife Refuge | Lake Huron | MI | 1983 | 695 acres (2.81 km2)[203] |
| Huron National Wildlife Refuge | Lake Superior | MI | 1905 | 147 acres (0.59 km2)[204] |
| Kirtlands Warbler Wildlife Management Area | Lower Peninsula of Michigan | MI | 1980 | 6,684 acres (27.05 km2)[205] |
| Michigan Islands National Wildlife Refuge | Lake Michigan Lake Huron | MI | 1943 | 744 acres (3.01 km2)[206] |
| Michigan Wetland Management District | Lower Peninsula of Michigan | MI | 1980 | 664 acres (2.69 km2)[207] |
| Seney National Wildlife Refuge | Schoolcraft County | MI | 1935 | 95,265 acres (385.52 km2)[208] |
| Shiawassee National Wildlife Refuge | Saginaw County | MI | 1953 | 9,870 acres (39.9 km2)[209] |
| Agassiz National Wildlife Refuge | Marshall County | MN | 1937 | 61,500 acres (249 km2)[210] |
| Big Stone National Wildlife Refuge | Big Stone County Lac qui Parle County | MN | 1975 | 11,586 acres (46.89 km2)[211] |
| Big Stone Wetland Management District | Lincoln County Lyon County | MN | 1975 | 3,000 acres (12 km2)[212] |
| Crane Meadows National Wildlife Refuge | Morrison County | MN | 1992 | 13,540 acres (54.8 km2)[213] |
| Detroit Lakes Wetland Management District | Northwestern Minnesota | MN | 1953 | 53,000 acres (210 km2)[214] |
| Fergus Falls Wetland Management District | West Central Minnesota | MN | 1962 | 72,699 acres (294.20 km2)[215] |
| Glacial Ridge National Wildlife Refuge | Polk County | MN | 2004 | 37,756 acres (152.79 km2)[216] |
| Hamden Slough National Wildlife Refuge | Becker County | MN | 1989 | 5,944 acres (24.05 km2)[217] |
| Litchfield Wetland Management District | Central Minnesota | MN | 1978 | 36,000 acres (150 km2)[218] |
| Mille Lacs National Wildlife Refuge | Mille Lacs County | MN | 1915 | 0.57 acres (0.0023 km2)[219] |
| Minnesota Valley National Wildlife Refuge | Carver County Dakota County Hennepin County Le Sueur County Scott County Sibley County | MN | 1976 | 14,000 acres (57 km2)[220] |
| Minnesota Valley Wetland Management District | Southeastern Minnesota | MN | 1988 | 8,000 acres (32 km2)[221] |
| Morris Wetland Management District | West Central Minnesota | MN | | 50,000 acres (200 km2)[222] |
| Northern Tallgrass Prairie National Wildlife Refuge | Minnesota Iowa | MN | 2000 | 5,000 acres (20 km2)[223] |
| Rice Lake National Wildlife Refuge | Aitkin County | MN | 1935 | 18,208 acres (73.69 km2)[224] |
| Rydell National Wildlife Refuge | Polk County | MN | 1992 | 2,120 acres (8.6 km2)[225] |
| Sherburne National Wildlife Refuge | Sherburne County | MN | 1965 | 30,700 acres (124 km2)[226] |
| Tamarac National Wildlife Refuge | Becker County | MN | 1938 | 42,724 acres (172.90 km2)[227] |
| Upper Mississippi River National Wildlife and Fish Refuge | Upper Mississippi River in: Illinois Iowa Minnesota Wisconsin | MN | 1924 | 240,000 acres (970 km2)[228] |
| Windom Wetland Management District | South Central Minnesota | MN | - | 14,000 acres (57 km2)[229] |
| Coldwater River National Wildlife Refuge | Quitman County Tallahatchie County | MS | 2000 | 2,069 acres (8.37 km2)[230] |
| Dahomey National Wildlife Refuge | Bolivar County | MS | 1990 | 9,691 acres (39.22 km2)[231] |
| Grand Bay National Wildlife Refuge | Jackson County Mobile County, Alabama | MS | 1992 | 32,000 acres (130 km2)[232] |
| Hillside National Wildlife Refuge | Holmes County | MS | 1975 | 15,572 acres (63.02 km2)[233] |
| Holt Collier National Wildlife Refuge | Washington County | MS | 2004 | 1,400 acres (5.7 km2)[234] |
| Mathews Brake National Wildlife Refuge | Leflore County | MS | 1980 | 2,418 acres (9.79 km2)[235] |
| Mississippi Sandhill Crane National Wildlife Refuge | Jackson County | MS | 1975 | 19,000 acres (77 km2)[236] |
| Morgan Brake National Wildlife Refuge | Holmes County | MS | 1977 | 7,383 acres (29.88 km2)[237] |
| Panther Swamp National Wildlife Refuge | Yazoo County | MS | 1978 | 38,697 acres (156.60 km2)[238] |
| Sam D. Hamilton Noxubee National Wildlife Refuge | Noxubee County Oktibbeha County Winston County | MS | 1940 | 48,000 acres (190 km2)[239] |
| St. Catherine Creek National Wildlife Refuge | Adams County | MS | 1990 | 34,256 acres (138.63 km2)[240] |
| Tallahatchie National Wildlife Refuge | Grenada County Tallahatchie County | MS | 1990 | 4,199 acres (16.99 km2)[241] |
| Theodore Roosevelt National Wildlife Refuge | Holmes County Humphreys County Leflore County Sharkey County Warren County Washington County | MS | 2004[242] | - |
| Yazoo National Wildlife Refuge | Washington County | MS | 1936 | 12,941 acres (52.37 km2)[243] |
| Big Muddy National Fish and Wildlife Refuge | Missouri River | MO | 1994 | 16,700 acres (68 km2)[244] |
| Clarence Cannon National Wildlife Refuge | Pike County | MO | 1964 | 3,750 acres (15.2 km2)[245] |
| Great River National Wildlife Refuge | Clark County Lewis County Adams County, Illinois Pike County, Illinois | MO | 1958 | 11,600 acres (47 km2)[246] |
| Loess Bluffs National Wildlife Refuge | Holt County | MO | 1935 | 7,415 acres (30.01 km2)[247] |
| Mingo National Wildlife Refuge | Stoddard County Wayne County | MO | 1944 | 21,676 acres (87.72 km2)[248] |
| Ozark Cavefish National Wildlife Refuge | Lawrence County | MO | 1991 | 40 acres (0.16 km2)[249] |
| Pilot Knob National Wildlife Refuge | Iron County | MO | 1987 | 90 acres (0.36 km2)[250] |
| Swan Lake National Wildlife Refuge | Chariton County | MO | 1937 | 10,795 acres (43.69 km2)[251] |
| Benton Lake National Wildlife Refuge | Cascade County | MT | 1929 | 12,459 acres (50.42 km2)[252] |
| Benton Lake Wetland Management District | Montana | MT | 1975 | 16,000 acres (65 km2)[253] |
| Black Coulee National Wildlife Refuge | Blaine County | MT | 1938 | 1,308 acres (5.29 km2)[254] |
| Bowdoin National Wildlife Refuge | Phillips County | MT | 1936 | 15,551 acres (62.93 km2)[255] |
| Charles M. Russell National Wildlife Refuge | Fergus County Garfield County McCone County Petroleum County Phillips County Valley County | MT | 1936 | 915,814 acres (3,706.17 km2)[256] |
| Creedman Coulee National Wildlife Refuge | Hill County | MT | 1941 | 2,728 acres (11.04 km2)[257] |
Grass Lake National Wildlife Refuge (formerly Halfbreed Lake NWR) | Stillwater County | MT | 1987 | 4,318 acres (17.47 km2)[258] |
| Hailstone National Wildlife Refuge | Stillwater County | MT | 1942 | 2,700 acres (11 km2)[259] |
| Hewitt Lake National Wildlife Refuge | Phillips County | MT | 1938 | 1,360 acres (5.5 km2)[260] |
| Lake Mason National Wildlife Refuge | Musselshell County | MT | 1941 | 16,814 acres (68.04 km2)[261] |
| Lake Thibadeau National Wildlife Refuge | Hill County | MT | 1937 | 3,868 acres (15.65 km2)[262] |
| Lamesteer National Wildlife Refuge | Wibaux County | MT | 1942 | 800 acres (3.2 km2)[262] |
| Lee Metcalf National Wildlife Refuge | Ravalli County | MT | 1964 | 2,800 acres (11 km2)[263] |
| Lost Trail National Wildlife Refuge | Flathead County | MT | 1999 | 8,834 acres (35.75 km2)[264] |
| Medicine Lake National Wildlife Refuge | Sheridan County Roosevelt County | MT | 1935 | 31,533 acres (127.61 km2)[265] |
| Ninepipe National Wildlife Refuge | Lake County | MT | 1921 | 4,027 acres (16.30 km2)[266] |
| Northwest Montana Wetland Management District | Montana | MT | 1970 | 14,752 acres (59.70 km2)[267] |
| Pablo National Wildlife Refuge | Lake County | MT | 1921 | 2,473 acres (10.01 km2)[268] |
| Red Rock Lakes National Wildlife Refuge | Beaverhead County | MT | 1932 | 65,810 acres (266.3 km2)[269] |
| Swan River National Wildlife Refuge | Lake County | MT | 1973 | 1,568 acres (6.35 km2)[270] |
| UL Bend National Wildlife Refuge | Phillips County | MT | 1969 | 56,048 acres (226.82 km2)[271] |
| War Horse National Wildlife Refuge | Petroleum County | MT | 1958 | 3,392 acres (13.73 km2)[272] |
| Boyer Chute National Wildlife Refuge | Washington County | NE | 1992 | 4,040 acres (16.3 km2)[273] |
| Crescent Lake National Wildlife Refuge | Garden County | NE | 1931 | 45,818 acres (185.42 km2)[274] |
| Fort Niobrara National Wildlife Refuge | Cherry County | NE | 1912 | 19,131 acres (77.42 km2)[275] |
| John and Louise Seier National Wildlife Refuge | Rock County | NE | 1999 | 2,400 acres (9.7 km2)[276] |
| North Platte National Wildlife Refuge | Scotts Bluff County | NE | 1916 | 5,047 acres (20.42 km2)[276] |
| Rainwater Basin Wetland Management District | South Central Nebraska | NE | 1963 | 22,864 acres (92.53 km2)[277] |
| Valentine National Wildlife Refuge | Cherry County | NE | 1935 | 71,516 acres (289.41 km2)[278] |
| Anaho Island National Wildlife Refuge | Washoe County | NV | 1913 | 247 acres (1.00 km2)[279] |
| Ash Meadows National Wildlife Refuge (Managed as part of theDesert National Wildlife Refuge Complex, headquartered inLas Vegas) | Nye County | NV | 1984 | 23,000 acres (93 km2)[280] |
| Desert National Wildlife Refuge (Managed as part of theDesert National Wildlife Refuge Complex, headquartered inLas Vegas) | Clark County Lincoln County | NV | 1936 | 1,615,000 acres (6,540 km2)[281] |
| Fallon National Wildlife Refuge | Churchill County | NV | 1931 | 15,000 acres (61 km2)[282] |
| Moapa Valley National Wildlife Refuge (Managed as part of theDesert National Wildlife Refuge Complex, headquartered inLas Vegas) | Clark County | NV | 1979 | 106 acres (0.43 km2)[283] |
| Pahranagat National Wildlife Refuge (Managed as part of theDesert National Wildlife Refuge Complex, headquartered inLas Vegas) | Lincoln County | NV | 1963 | 5,380 acres (21.8 km2)[284] |
| Ruby Lake National Wildlife Refuge | Elko County White Pine County | NV | 1938 | 37,632 acres (152.29 km2)[285] |
| Sheldon National Wildlife Refuge (Managed as part of theSheldon-Hart Mountain National Wildlife Refuge Complex, headquartered inLakeview, Oregon) | Humboldt County Washoe County Lake County, Oregon | NV | 1931 | 573,504 acres (2,320.89 km2)[286] |
| Stillwater National Wildlife Refuge | Churchill County | NV | 1949 | 79,570 acres (322.0 km2)[287] |
| Great Bay National Wildlife Refuge | Rockingham County | NH | 1992 | 1,116 acres (4.52 km2)[288] |
| John Hay National Wildlife Refuge | Merrimack County | NH | 1987 | 164 acres (0.66 km2)[289] |
| Umbagog National Wildlife Refuge | Coös County Oxford County, Maine | NH | 1992 | 25,650 acres (103.8 km2)[290] |
| Wapack National Wildlife Refuge | Hillsborough County | NH | 1972 | 1,672 acres (6.77 km2)[291] |
| Cape May National Wildlife Refuge | Cape May County | NJ | 1989 | 21,200 acres (86 km2)[292] |
| Edwin B. Forsythe National Wildlife Refuge | Atlantic County Ocean County | NJ | 1984 | 47,437 acres (191.97 km2)[293] |
| Great Swamp National Wildlife Refuge | Morris County | NJ | 1960 | 7,800 acres (32 km2)[294] |
| Supawna Meadows National Wildlife Refuge | Salem County | NJ | 1974 | 3,230 acres (13.1 km2)[295] |
| Wallkill River National Wildlife Refuge | Sussex County Orange County, New York | NJ | 1990 | 5,100 acres (21 km2)[296] |
| Bitter Lake National Wildlife Refuge | Chaves County | NM | 1937 | 24,563 acres (99.40 km2)[297] |
| Bosque del Apache National Wildlife Refuge | Socorro County | NM | 1939 | 57,331 acres (232.01 km2)[298] |
| Grulla National Wildlife Refuge | Roosevelt County Bailey County, Texas | NM | 1969 | 3,264 acres (13.21 km2)[299] |
| Las Vegas National Wildlife Refuge (Managed as part of theNorthern New Mexico National Wildlife Refuge Complex) | San Miguel County | NM | 1965 | 8,672 acres (35.09 km2)[300] |
| Rio Mora National Wildlife Refuge (Managed as part of theNorthern New Mexico National Wildlife Refuge Complex) | Mora County | NM | 2012 | 4,224 acres (17.09 km2)[301] |
| Maxwell National Wildlife Refuge (Managed as part of theNorthern New Mexico National Wildlife Refuge Complex) | Colfax County | NM | 1965 | 3,699 acres (14.97 km2)[302] |
| San Andres National Wildlife Refuge | Doña Ana County | NM | 1941 | 57,215 acres (231.54 km2)[303] |
| Sevilleta National Wildlife Refuge | Socorro County | NM | 1973 | 230,000 acres (930 km2)[304] |
| Valle de Oro National Wildlife Refuge | Bernalillo County | NM | 2012 | 570 acres (2.3 km2)[305] |
| Amagansett National Wildlife Refuge (Part of theLong Island National Wildlife Refuge Complex) | Suffolk County | NY | 1968 | 36 acres (0.15 km2)[306] |
| Conscience Point National Wildlife Refuge (Part of theLong Island National Wildlife Refuge Complex) | Suffolk County | NY | 1971 | 60 acres (0.24 km2)[307] |
| Elizabeth A. Morton National Wildlife Refuge (Part of theLong Island National Wildlife Refuge Complex) | Suffolk County | NY | 1954 | 187 acres (0.76 km2)[308] |
| Iroquois National Wildlife Refuge | Genesee County Orleans County | NY | 1958 | 10,828 acres (43.82 km2)[309] |
| Montezuma National Wildlife Refuge | Seneca County | NY | 1937 | 10,004 acres (40.48 km2)[310] |
| Oyster Bay National Wildlife Refuge (Part of theLong Island National Wildlife Refuge Complex) | Nassau County | NY | 1968 | 3,209 acres (12.99 km2)[311] |
| Sayville National Wildlife Refuge (Part of theLong Island National Wildlife Refuge Complex) | Suffolk County | NY | 1992 | 127 acres (0.51 km2)[312] |
| Seatuck National Wildlife Refuge (Part of theLong Island National Wildlife Refuge Complex) | Suffolk County | NY | 1968 | 196 acres (0.79 km2)[313] |
| Shawangunk Grasslands National Wildlife Refuge | Ulster County | NY | 1999 | 597 acres (2.42 km2)[314] |
| Target Rock National Wildlife Refuge (Part of theLong Island National Wildlife Refuge Complex) | Suffolk County | NY | 1967 | 80 acres (0.32 km2)[315] |
| Wertheim National Wildlife Refuge (Part of theLong Island National Wildlife Refuge Complex) | Suffolk County | NY | 1947 | 2,550 acres (10.3 km2)[316] |
| Alligator River National Wildlife Refuge (Part of theNorth Carolina Coastal Plain National Wildlife Refuge Complex) | Dare County Hyde County | NC | 1984 | 152,000 acres (620 km2)[317] |
| Cedar Island National Wildlife Refuge (Part of theMattamuskeet, Swanquarter and Cedar Island National Wildlife Refuge Complex) | Carteret County | NC | 1964 | 14,480 acres (58.6 km2)[318] |
| Currituck National Wildlife Refuge (Part of theNorth Carolina Coastal Plain National Wildlife Refuge Complex) | Currituck County | NC | 1984 | 8,316 acres (33.65 km2)[319] |
| Mackay Island National Wildlife Refuge (Part of theNorth Carolina Coastal Plain National Wildlife Refuge Complex) | Currituck County Virginia Beach,Virginia | NC | 1960 | 8,231 acres (33.31 km2)[320] |
| Mattamuskeet National Wildlife Refuge (Part of theMattamuskeet, Swanquarter and Cedar Island National Wildlife Refuge Complex) | Hyde County | NC | 1934 | 50,173 acres (203.04 km2)[321] |
| Mountain Bogs National Wildlife Refuge | Ashe County | NC | 2015 | 39 acres (0.16 km2)[322] |
| Pea Island National Wildlife Refuge (Part of theNorth Carolina Coastal Plain National Wildlife Refuge Complex) | Dare County | NC | 1938 | 31,534 acres (127.61 km2)[323] |
| Pee Dee National Wildlife Refuge | Anson County Richmond County | NC | 1963 | 8,443 acres (34.17 km2)[324] |
| Pocosin Lakes National Wildlife Refuge (Part of theNorth Carolina Coastal Plain National Wildlife Refuge Complex) | Hyde County Tyrrell County Washington County | NC | 1963 | 110,106 acres (445.58 km2)[325] |
| Roanoke River National Wildlife Refuge (Part of theNorth Carolina Coastal Plain National Wildlife Refuge Complex) | Bertie County | NC | 1989 | 20,978 acres (84.89 km2)[326] |
| Swanquarter National Wildlife Refuge (Part of theMattamuskeet, Swanquarter and Cedar Island National Wildlife Refuge Complex) | Hyde County | NC | 1932 | 16,411 acres (66.41 km2)[327] |
| Appert Lake National Wildlife Refuge | Emmons County | ND | 1930s | 1,978 acres (8.00 km2) Easement on private land[328] |
| Ardoch National Wildlife Refuge (Managed by theDevils Lake Wetland Management District) | Walsh County | ND | 1939[329] | 3,084 acres (12.48 km2)[330] Easement on private land[331] |
| Arrowwood National Wildlife Refuge (Managed by theArrowwood National Wildlife Refuge Complex) | Stutsman County | ND | 1935 | 15,934 acres (64.48 km2)[332] |
| Arrowwood Wetland Management District (Managed by theArrowwood National Wildlife Refuge Complex) | Eddy County Foster County | ND | 1961 | 6,162 acres (24.94 km2)[333] |
| Audubon National Wildlife Refuge (Managed by theAudubon National Wildlife Refuge Complex) | McLean County | ND | 1956 (renamed 1967) | 14,735 acres (59.63 km2)[334] |
| Audubon Wetland Management District (Managed by theAudubon National Wildlife Refuge Complex) | McLean County Sheridan County | ND | 1950s | 155,000 acres (630 km2) 84 waterfowl production areas[335] |
| Bone Hill National Wildlife Refuge | LaMoure County | ND | 1939 | 1,978 acres (8.00 km2) Easement on private land[336] |
| Brumba National Wildlife Refuge | Towner County | ND | 1939[337] | Easement on private land[338] |
| Buffalo Lake National Wildlife Refuge (North Dakota) | Pierce County | ND | | Easement on private land[339] |
| Camp Lake National Wildlife Refuge | McLean County | ND | | 585 acres (2.37 km2) Easement on private land[340] |
| Canfield Lake National Wildlife Refuge | Burleigh County | ND | | 1,978 acres (8.00 km2) Easement on private land[341] |
| Chase Lake National Wildlife Refuge (Managed by theArrowwood National Wildlife Refuge Complex) | Stutsman County | ND | 1908 | 4,385 acres (17.75 km2)[342] |
| Chase Lake Wetland Management District (Managed by theArrowwood National Wildlife Refuge Complex) | Stutsman County Wells County | ND | 1993 | 162,925 acres (659.33 km2) 135 waterfowl production areas[343] |
| Cottonwood Lake National Wildlife Refuge | McHenry County | ND | 1939[344] | Easement on private land[345] |
| Crosby Wetland Management District (Managed by theLostwood Wetland Management District Complex) | Burke County Divide County Williams County | ND | 1962 | 21,219 acres (85.87 km2) 90 waterfowl production areas[346] |
| Dakota Lake National Wildlife Refuge | Dickey County | ND | 1939 | 2,784 acres (11.27 km2) Easement on private land[328] |
| Des Lacs National Wildlife Refuge (Managed by theLostwood Wetland Management District Complex) | Burke County Ward County | ND | 1935 | 19,500 acres (79 km2)[347] |
| Devils Lake Wetland Management District (Managed by theDevils Lake Wetland Management District) | Benson County Cavalier County Grand Forks County Pembina County Ramsey County Towner County Walsh County | ND | | 258,000 acres (1,040 km2) 257 waterfowl production areas[348] |
| Florence Lake National Wildlife Refuge (Managed by theLong Lake National Wildlife Refuge Complex) | Burleigh County | ND | 1939 | 1,888.2 acres (7.641 km2)[349] |
| Half-Way Lake National Wildlife Refuge | Stutsman County | ND | 1939 | 160 acres (0.65 km2) Easement on private land[350] |
| Hiddenwood National Wildlife Refuge | McLean County | ND | 1939[351] | 675 acres (2.73 km2) Easement on private land[352] |
| Hobart Lake National Wildlife Refuge | Barnes County | ND | 1939[353] | 2,077 acres (8.41 km2) Easement on private land[354] |
| Hutchinson Lake National Wildlife Refuge | Kidder County | ND | | Easement on private land[355] |
| J. Clark Salyer National Wildlife Refuge (Managed by theJ. Clark Salyer National Wildlife Refuge Complex) | Bottineau County McHenry County | ND | 1935 | 58,700 acres (238 km2)[356] |
| J. Clark Salyer Wetland Management District (Managed by theJ. Clark Salyer National Wildlife Refuge Complex) | Bottineau County McHenry County Pierce County Renville County Rolette County | ND | 1966 | 185,090 acres (749.0 km2)[357] |
| Johnson Lake National Wildlife Refuge | Eddy County Nelson County | ND | 1939 | 2,002 acres (8.10 km2) Easement on private land[358] |
| Kellys Slough National Wildlife Refuge (Managed by theDevils Lake Wetland Management District) | Grand Forks County | ND | 1936 | 2,146 acres (8.68 km2)[359] |
| Kulm Wetland Management District | Dickey County LaMoure County Logan County McIntosh County | ND | 1971 | 279,184 acres (1,129.82 km2) 200 waterfowl production areas[360] |
| Lake Alice National Wildlife Refuge (Managed by theDevils Lake Wetland Management District) | Ramsey County | ND | 1935 | 8,512 acres (34.45 km2)[361] |
| Lake George National Wildlife Refuge | Stutsman County | ND | 1939[362] | Easement on private land[363] |
| Lake Ilo National Wildlife Refuge (Managed by theAudubon National Wildlife Refuge Complex) | Dunn County | ND | 1939 | 4,000 acres (16 km2)[364] |
| Lake Nettie National Wildlife Refuge (Managed by theAudubon National Wildlife Refuge Complex) | McLean County | ND | 1939[365] | 1,285 acres (5.20 km2)[366] |
| Lake Otis National Wildlife Refuge | McLean County | ND | | 320 acres (1.3 km2) Easement on private land[367] |
| Lake Patricia National Wildlife Refuge | Morton County | ND | 1939[368] | 800 acres (3.2 km2) Easement on private land[369] |
| Lake Zahl National Wildlife Refuge (Managed by theLostwood Wetland Management District Complex) | Williams County | ND | 1939[370] | 3,823 acres (15.47 km2)[371] |
| Lambs Lake National Wildlife Refuge | Nelson County | ND | 1939[372] | Easement on private land[373] |
| Little Goose National Wildlife Refuge | Grand Forks County | ND | | Easement on private land[374] |
| Long Lake National Wildlife Refuge (Managed by theLong Lake National Wildlife Refuge Complex) | Burleigh County | ND | 1932 | 22,300 acres (90 km2)[375] |
| Long Lake Wetland Management District (Managed by theLong Lake National Wildlife Refuge Complex) | Kidder County Burleigh County Emmons County | ND | 1950s | 100,000 acres (400 km2)[376] |
| Lords Lake National Wildlife Refuge | Bottineau County | ND | | Easement on private land[377] |
| Lost Lake National Wildlife Refuge | McLean County | ND | | 960 acres (3.9 km2) Easement on private land[378] |
| Lostwood National Wildlife Refuge (Managed by theLostwood Wetland Management District Complex) | Burke County Mountrail County | ND | 1940[379] | 27,589 acres (111.65 km2)[380] |
| Lostwood Wetland Management District (Managed by theLostwood Wetland Management District Complex) | Mountrail County Ward County | ND | 1961 | Scattered small tracts[381] |
| Maple River National Wildlife Refuge | Dickey County | ND | 1939[382] | 414 acres (1.68 km2) Federal land 1,120 acres (4.5 km2) Easement on private land[383] |
| McLean National Wildlife Refuge | McLean County | ND | 1939 (as Lake Susie NWR) | 760 acres (3.1 km2)[384] |
| Pleasant Lake National Wildlife Refuge | Benson County | ND | 1939[385] | 1,000 acres (4.0 km2) Easement on private land[328] |
| Pretty Rock National Wildlife Refuge | Grant County | ND | 760 | 800 acres (3.2 km2) Easement on private land[386] |
| Rabb Lake National Wildlife Refuge | Rolette County | ND | | Easement on private land[387] |
| Rock Lake National Wildlife Refuge | Towner County | ND | 1939[388] | Easement on private land[389] |
| Rose Lake National Wildlife Refuge | Nelson County | ND | 1948 | 872.1 acres (3.529 km2) Easement on private land[390] |
| School Section Lake National Wildlife Refuge | Rolette County | ND | 1935 | Easement on private land[391] |
| Shell Lake National Wildlife Refuge (Managed by theLostwood Wetland Management District Complex) | Mountrail County | ND | 1939[392] | 1,835 acres (7.43 km2)[393] |
| Sibley Lake National Wildlife Refuge | Griggs County | ND | | 1,077 acres (4.36 km2) Easement on private land[394] |
| Silver Lake National Wildlife Refuge | Benson County | ND | 1938 | 398.76 acres (1.6137 km2) Easement on private land[395] |
| Slade National Wildlife Refuge (Managed by theLong Lake National Wildlife Refuge Complex) | Kidder County | ND | 1940 | 3,000 acres (12 km2)[396] |
| Snyder Lake National Wildlife Refuge | Towner County | ND | 1941 | Easement on private land[397] |
| Springwater National Wildlife Refuge | Emmons County | ND | | Easement on private land[398] |
| Stewart Lake National Wildlife Refuge (Managed by theAudubon National Wildlife Refuge Complex) | Slope County | ND | 1941 | 730 acres (3.0 km2) federal land 1,600 acres (6.5 km2) easement on private land[399] |
| Stoney Slough National Wildlife Refuge | Barnes County | ND | 1941 | 1,120 acres (4.5 km2) Federal land 880 acres (3.6 km2) Easement on private land[400] |
| Storm Lake National Wildlife Refuge | Sargent County | ND | | Easement on private land[401] |
| Stump Lake National Wildlife Refuge | Nelson County | ND | 1905 | Currently under water[402] |
| Sunburst Lake National Wildlife Refuge | Emmons County | ND | | 328 acres (1.33 km2) Easement on private land[403] |
| Tewaukon National Wildlife Refuge (Managed by theSouris River Basin National Wildlife Refuge Complex) | Sargent County | ND | 1945 | 8,343 acres (33.76 km2)[404] |
| Tewaukon Wetland Management District (Managed by theTewaukon National Wildlife Refuge Complex) | Ransom County Richland County Sargent County | ND | | 49,000 acres (200 km2)[405] |
| Tomahawk National Wildlife Refuge | Barnes County | ND | | 440 acres (1.8 km2) Easement on private land[406] |
| Upper Souris National Wildlife Refuge (Managed by theSouris River Basin National Wildlife Refuge Complex) | Renville County Ward County | ND | 1932 | 32,092 acres (129.87 km2)[407] |
| Valley City Wetland Management District (Managed by theArrowwood National Wildlife Refuge Complex) | Barnes County Cass County Griggs County Steele County Traill County | ND | 1971 | 89,000 acres (360 km2) 82 waterfowl production areas[408] |
| White Lake National Wildlife Refuge (Managed by theAudubon National Wildlife Refuge Complex) | Slope County | ND | 1941 | 1,040 acres (4.2 km2)[409] |
| White Horse Hill National Game Preserve (Managed by theDevils Lake Wetland Management District) | Benson County | ND | 1904 | 1,674 acres (6.77 km2)[410] |
| Wild Rice Lake National Wildlife Refuge | Sargent County | ND | | Easement on private land[411] |
| Willow Lake National Wildlife Refuge | Rolette County | ND | | Easement on private land[412] |
| Wintering River National Wildlife Refuge | McHenry County | ND | | Easement on private land[413] |
| Wood Lake National Wildlife Refuge | Benson County | ND | 1935 | Easement on private land[414] |
| Cedar Point National Wildlife Refuge (Managed by theOttawa National Wildlife Refuge Complex) | Lucas County | OH | 1965 | 2,449.77 acres (9.9139 km2)[415] |
| Ottawa National Wildlife Refuge (Managed by theOttawa National Wildlife Refuge Complex) | Lucas County Ottawa County | OH | 1961 | 6,857.91 acres (27.7530 km2)[416] |
| West Sister Island National Wildlife Refuge (Managed by theOttawa National Wildlife Refuge Complex) | Lucas County | OH | 1937 | 77 acres (0.31 km2)[417] |
| Deep Fork National Wildlife Refuge | Okmulgee County | OK | 1993 | 9,748 acres (39.45 km2)[418] |
| Little River National Wildlife Refuge | McCurtain County | OK | 1987 | 13,660 acres (55.3 km2)[419] |
| Optima National Wildlife Refuge | Texas County | OK | 1975 | 4,333 acres (17.54 km2)[420] |
| Ozark Plateau National Wildlife Refuge | Adair County Cherokee County Delaware County Ottawa County | OK | 1986 | 4,200 acres (17 km2)[421] |
| Salt Plains National Wildlife Refuge | Alfalfa County | OK | 1930 | 32,197 acres (130.30 km2)[422] |
| Sequoyah National Wildlife Refuge | Haskell County Muskogee County Sequoyah County | OK | 1970 | 20,800 acres (84 km2)[423] |
| Tishomingo National Wildlife Refuge | Johnston County Marshall County | OK | 1946 | 16,464 acres (66.63 km2)[424] |
| Washita National Wildlife Refuge | Custer County | OK | 1961 | 8,075 acres (32.68 km2)[425] |
| Wichita Mountains Wildlife Refuge | Comanche County | OK | 1901 | 59,020 acres (238.8 km2)[426] |
| Ankeny National Wildlife Refuge | Marion County | OR | 1965 | 2,796 acres (11.32 km2)[427] |
| Bandon Marsh National Wildlife Refuge | Coos County | OR | 1983 | 864 acres (3.50 km2)[428] |
| Baskett Slough National Wildlife Refuge | Polk County | OR | 1965 | 2,492 acres (10.08 km2)[429] |
| Bear Valley National Wildlife Refuge | Klamath County | OR | 1978 | 4,200 acres (17 km2)[430] |
| Cape Meares National Wildlife Refuge | Tillamook County | OR | 1938 | 138.51 acres (0.5605 km2)[431] |
| Cold Springs National Wildlife Refuge | Umatilla County | OR | 1909 | 3,117 acres (12.61 km2)[432] |
| Deer Flat National Wildlife Refuge | Malheur County Baker County Canyon County, Idaho Owyhee County, Idaho Payette County, Idaho Washington County, Idaho | OR | 1909 | 10,548 acres (42.69 km2)[122] |
| Hart Mountain National Antelope Refuge | Lake County | OR | 1936 | 270,608 acres (1,095.11 km2)[433] |
| Julia Butler Hansen Refuge for the Columbian White-Tailed Deer | Clatsop County Columbia County Wahkiakum County, Washington | OR | 1972 | 5,600 acres (23 km2)[434] |
| Klamath Marsh National Wildlife Refuge | Klamath County | OR | 1958 | 40,885 acres (165.46 km2)[435] |
| Lewis and Clark National Wildlife Refuge | Clatsop County | OR | 1972 | 12,167 acres (49.24 km2)[436] |
| Lower Klamath National Wildlife Refuge | Klamath County Siskiyou County, California | OR | 1908 | 187,757 acres (759.83 km2)[437] |
| Malheur National Wildlife Refuge | Harney County | OR | 1908 | 187,757 acres (759.83 km2)[438] |
| McKay Creek National Wildlife Refuge | Umatilla County | OR | 1991 | 1,836.5 acres (7.432 km2)[439] |
| Nestucca Bay National Wildlife Refuge | Tillamook County | OR | 1991 | 1,202 acres (4.86 km2)[440] |
| Oregon Islands National Wildlife Refuge | Oregon Coast | OR | 1935 | 1,083 acres (4.38 km2)[441] |
| Sheldon National Wildlife Refuge | Lake County Humboldt County, Nevada Washoe County, Nevada | OR | 1931 | 573,504 acres (2,320.89 km2)[286] |
| Siletz Bay National Wildlife Refuge | Lincoln County | OR | 1991 | 568 acres (2.30 km2)[442] |
| Three Arch Rocks National Wildlife Refuge | Tillamook County | OR | 1907 | 15 acres (0.061 km2)[443] |
| Tualatin River National Wildlife Refuge | Washington County Yamhill County | OR | 1992 | 1,856 acres (7.51 km2)[444] |
| Umatilla National Wildlife Refuge | Morrow County Benton County, Washington | OR | 1969 | 23,783 acres (96.25 km2)[445] |
| Upper Klamath National Wildlife Refuge | Klamath County | OR | 1928 | 14,400 acres (58 km2)[446] |
| Wapato Lake National Wildlife Refuge | Washington County Yamhill County | OR | 2013 | 4,310 acres (17.4 km2)[447] |
| William L. Finley National Wildlife Refuge | Benton County | OR | 1964 | 5,706 acres (23.09 km2)[448] |
| Cherry Valley National Wildlife Refuge | Monroe County | PA | 2008 | 185 acres (0.75 km2)[449] |
| Erie National Wildlife Refuge | Crawford County | PA | 1959 | 8,800 acres (36 km2)[450] |
| John Heinz National Wildlife Refuge at Tinicum | Delaware County Philadelphia County | PA | 1972 | 1,200 acres (4.9 km2)[451] |
| Cabo Rojo National Wildlife Refuge (Managed by theCaribbean Islands National Wildlife complex) | Cabo Rojo | PR | 1974 | 1,836 acres (7.43 km2)[452] |
| Culebra National Wildlife Refuge (Managed by theCaribbean Islands National Wildlife complex) | Isla Culebra | PR | 1909 | 1,450 acres (5.9 km2)[453] |
| Desecheo National Wildlife Refuge (Managed by theCaribbean Islands National Wildlife complex) | Mayagüez | PR | 1976 | 360 acres (1.5 km2)[454] |
| Laguna Cartagena National Wildlife Refuge (Managed by theCaribbean Islands National Wildlife complex) | Lajas | PR | 1989 | 1,059 acres (4.29 km2)[455] |
| Vieques National Wildlife Refuge (Managed by theCaribbean Islands National Wildlife complex) | Isla de Vieques | PR | 2001 | 17,771 acres (71.92 km2)[456] |
| Block Island National Wildlife Refuge (Managed by theRhode Island National Wildlife Refuge Complex) | Washington County | RI | 1973 | 127 acres (0.51 km2)[457] |
| John H. Chafee National Wildlife Refuge (Managed by theRhode Island National Wildlife Refuge Complex) | Washington County | RI | 1988 | 317 acres (1.28 km2)[458] |
| Ninigret National Wildlife Refuge (Managed by theRhode Island National Wildlife Refuge Complex) | Washington County | RI | 1970 | 900 acres (3.6 km2)[459] |
| Sachuest Point National Wildlife Refuge (Managed by theRhode Island National Wildlife Refuge Complex) | Newport County | RI | 1970 | 242 acres (0.98 km2)[460] |
| Trustom Pond National Wildlife Refuge (Managed by theRhode Island National Wildlife Refuge Complex) | Washington County | RI | 1974 | 787 acres (3.18 km2)[461] |
| Cape Romain National Wildlife Refuge (Part of theSouth Carolina Lowcountry National Wildlife Refuge Complex) | Charleston County | SC | 1932 | 66,287 acres (268.25 km2)[462] |
| Carolina Sandhills National Wildlife Refuge | Chesterfield County | SC | 1939 | 45,348 acres (183.52 km2)[463] |
| Ernest F. Hollings ACE Basin National Wildlife Refuge (Part of theSouth Carolina Lowcountry National Wildlife Refuge Complex) | Beaufort County Charleston County Colleton County Hampton County | SC | 1990 | 11,815 acres (47.81 km2)[464] |
| Pinckney Island National Wildlife Refuge (Part of theSavannah Coastal Refuges Complex) | Beaufort County | SC | 1975 | 4,053 acres (16.40 km2)[465] |
| Santee National Wildlife Refuge (Part of theSavannah Coastal Refuges Complex) | Clarendon County | SC | 1941 | 15,000 acres (61 km2)[466] |
| Tybee National Wildlife Refuge (Part of theSavannah Coastal Refuges Complex) | Jasper County | SC | 1938 | 100 acres (0.40 km2)[467] |
| Waccamaw National Wildlife Refuge (Part of theSouth Carolina Lowcountry National Wildlife Refuge Complex) | Georgetown County Horry County Marion County | SC | 1997 | 22,931 acres (92.80 km2)[468] |
| Bear Butte National Wildlife Refuge | Meade County | SD | 1935 | 374 acres (1.51 km2)[469] |
| Huron Wetland Management District | Central South Dakota | SD | 1992 | 17,518 acres (70.89 km2)[470] |
| Karl E. Mundt National Wildlife Refuge | Gregory County Boyd County, Nebraska | SD | 1974 | 1,085 acres (4.39 km2)[471] |
| Lacreek National Wildlife Refuge | Bennett County | SD | 1935 | 16,410 acres (66.4 km2)[472] |
| Lake Andes National Wildlife Refuge | Charles Mix County | SD | 1936 | 5,638 acres (22.82 km2)[473] |
| Lake Andes Wetland Management District | Southeast South Dakota | SD | 1961 | 82,731 acres (334.80 km2)[474] |
| Madison Wetland Management District | East Central South Dakota | SD | 1969 | 129,700 acres (525 km2)[475] |
| Sand Lake National Wildlife Refuge | Brown County | SD | 1935 | 21,498 acres (87.00 km2)[476] |
| Sand Lake Wetland Management District | North Central South Dakota | SD | 1961 | 45,000 acres (180 km2)[477] |
| Waubay National Wildlife Refuge | Day County | SD | 1935 | 4,650 acres (18.8 km2)[478] |
| Waubay Wetland Management District | Northeast South Dakota | SD | 1935 | 40,000 acres (160 km2)[479] |
| Chickasaw National Wildlife Refuge (Part of theWest Tennessee National Wildlife Refuge Complex) | Lauderdale County | TN | 1985 | 25,006 acres (101.20 km2)[480] |
| Cross Creeks National Wildlife Refuge | Stewart County | TN | 1962 | 8,862 acres (35.86 km2)[481] |
| Hatchie National Wildlife Refuge | Hardeman County Haywood County | TN | 1964 | 11,556 acres (46.77 km2)[482] |
| Lake Isom National Wildlife Refuge (Part of theWest Tennessee National Wildlife Refuge Complex) | Lake County | TN | 1938 | 1,846 acres (7.47 km2)[483] |
| Lower Hatchie National Wildlife Refuge (Part of theWest Tennessee National Wildlife Refuge Complex) | Lauderdale County Tipton County | TN | 1980 | 9,451 acres (38.25 km2)[484] |
| Paint Rock River National Wildlife Refuge[485] | Jackson County | TN | 2023 | 87 acres (0.35 km2)[486] |
| Reelfoot National Wildlife Refuge (Part of theWest Tennessee National Wildlife Refuge Complex) | Lake County Obion County Fulton County, Kentucky | TN | 1941 | 10,428 acres (42.20 km2)[487] |
| Tennessee National Wildlife Refuge | Benton County Decatur County Henry County Humphreys County | TN | 1945 | 51,359 acres (207.84 km2)[488] |
| Aransas National Wildlife Refuge | Aransas County Calhoun County Refugio County | TX | 1937 | 114,657 acres (464.00 km2)[489] |
| Attwater Prairie Chicken National Wildlife Refuge | Colorado County | TX | 1972 | 10,528 acres (42.61 km2)[490] |
| Balcones Canyonlands National Wildlife Refuge | Burnet County Travis County Williamson County | TX | 1992 | 46,080 acres (186.5 km2)[491] |
| Big Boggy National Wildlife Refuge | Matagorda County | TX | 1983 | 5,000 acres (20 km2)[492] |
| Brazoria National Wildlife Refuge | Brazoria County | TX | 1969 | 44,414 acres (179.74 km2)[493] |
| Buffalo Lake National Wildlife Refuge | Randall County | TX | 1958 | 7,680 acres (31.1 km2)[494] |
| Caddo Lake National Wildlife Refuge | Harrison County | TX | 2000 | 8,493 acres (34.37 km2)[495] |
| Hagerman National Wildlife Refuge | Grayson County | TX | 1946 | 11,320 acres (45.8 km2)[496] |
| Jocelyn Nungaray National Wildlife Refuge (formerly Anahuac NWR) (Administered as part of theTexas Chenier Plain Refuge Complex) | Chambers County | TX | 1963 | 37,000 acres (150 km2)[497] |
| Laguna Atascosa National Wildlife Refuge | Cameron County Willacy County | TX | 1946 | 65,096 acres (263.43 km2)[498] |
| Lower Rio Grande Valley National Wildlife Refuge | Cameron County Hidalgo County Starr County Zapata County | TX | 1979 | 90,788 acres (367.41 km2)[499] |
| McFaddin National Wildlife Refuge (Administered as part of theTexas Chenier Plain Refuge Complex) | Jefferson County | TX | 1980 | 58,861 acres (238.20 km2)[500] |
| Moody National Wildlife Refuge (Administered as part of theTexas Chenier Plain Refuge Complex) | Chambers County | TX | 1961 | 3,517 acres (14.23 km2)[501] (Easement on private land) |
| Muleshoe National Wildlife Refuge | Bailey County | TX | 1935 | 6,440 acres (26.1 km2)[502] |
| Neches River National Wildlife Refuge | Anderson County Cherokee County | TX | 2006 | 4,404 acres (17.82 km2)[503] |
| San Bernard National Wildlife Refuge | Brazoria County Matagorda County | TX | 1969 | 45,730 acres (185.1 km2)[504] |
| Santa Ana National Wildlife Refuge | Hidalgo County | TX | 1943 | 2,088 acres (8.45 km2)[505] |
| Texas Point National Wildlife Refuge (Administered as part of theTexas Chenier Plain Refuge Complex) | Jefferson County | TX | 1979 | 8,972 acres (36.31 km2)[506] |
| Trinity River National Wildlife Refuge | Liberty County | TX | 1994 | 30,000 acres (120 km2)[507] |
| Bear River Migratory Bird Refuge | Box Elder County | UT | 1928 | 79,000 acres (320 km2)[508] |
| Fish Springs National Wildlife Refuge | Juab County | UT | 1959 | 17,992 acres (72.81 km2)[509] |
| Ouray National Wildlife Refuge | Uintah County | UT | 1960 | 11,987 acres (48.51 km2)[510] |
| Missisquoi National Wildlife Refuge | Franklin County | VT | 1943 | 6,642 acres (26.88 km2)[511] |
| Buck Island National Wildlife Refuge (Managed by theCaribbean Islands National Wildlife complex) | St. Thomas | VI | 1969 | 45 acres (0.18 km2)[512] |
| Green Cay National Wildlife Refuge (Managed by theCaribbean Islands National Wildlife complex) | St. Croix | VI | 1977 | 14 acres (0.057 km2)[513] |
| Sandy Point National Wildlife Refuge (Managed by theCaribbean Islands National Wildlife complex) | St. Croix | VI | 1984 | 360 acres (1.5 km2)[514] |
| Back Bay National Wildlife Refuge | Virginia Beach | VA | 1938 | 9,062 acres (36.67 km2)[515] |
| Chincoteague National Wildlife Refuge | Accomack County Worcester County, Maryland | VA | 1943 | 14,000 acres (57 km2)[516] |
| Eastern Shore of Virginia National Wildlife Refuge | Northampton County | VA | 1984 | 1,127 acres (4.56 km2)[517] |
| Elizabeth Hartwell Mason Neck National Wildlife Refuge (Part of thePotomac River National Wildlife Refuge Complex) | Fairfax County | VA | 1969 | 2,277 acres (9.21 km2)[518] |
| Featherstone National Wildlife Refuge (Part of thePotomac River National Wildlife Refuge Complex) | Prince William County | VA | 1970 | 325 acres (1.32 km2)[519] |
| Fisherman Island National Wildlife Refuge | Northampton County | VA | 1973 | 1,850 acres (7.5 km2)[520] |
| Great Dismal Swamp National Wildlife Refuge | Chesapeake Suffolk Camden County, North Carolina Gates County, North Carolina Pasquotank County, North Carolina | VA | 1974 | 112,000 acres (450 km2)[521] |
| James River National Wildlife Refuge (Part of theEastern Virginia Rivers National Wildlife Refuge Complex) | Prince George County | VA | 1991 | 4,200 acres (17 km2)[522] |
| Nansemond National Wildlife Refuge | Suffolk | VA | 1973 | 411 acres (1.66 km2)[523] |
| Occoquan Bay National Wildlife Refuge (Part of thePotomac River National Wildlife Refuge Complex) | Prince William County | VA | 1998 | 644 acres (2.61 km2)[524] |
| Plum Tree Island National Wildlife Refuge^ | Poquoson | VA | 1972 | 3,501 acres (14.17 km2)[525] |
| Presquile National Wildlife Refuge (Part of theEastern Virginia Rivers National Wildlife Refuge Complex) | Chesterfield County | VA | 1953 | 1,329 acres (5.38 km2)[526] |
| Rappahannock River Valley National Wildlife Refuge (Part of theEastern Virginia Rivers National Wildlife Refuge Complex) | Caroline County Essex County King George County Richmond County | VA | 1996 | 9,030 acres (36.5 km2)[527] |
| Wallops Island National Wildlife Refuge | Wallops Island,Accomack County | VA | 1975 | 373 acres (1.51 km2)[528] |
| Billy Frank Jr. Nisqually National Wildlife Refuge | Thurston County Pierce County | WA | 1974 | 4,529 acres (18.33 km2)[529] |
| Columbia National Wildlife Refuge | Adams County Grant County | WA | 1944 | 29,596 acres (119.77 km2)[530] |
| Conboy Lake National Wildlife Refuge | Klickitat County | WA | 1964 | 7,072 acres (28.62 km2)[531] |
| Copalis National Wildlife Refuge (Part of theWashington Maritime National Wildlife Refuge Complex) | Grays Harbor County | WA | 1907 | 60.8 acres (0.246 km2)[532] |
| Dungeness National Wildlife Refuge (Part of theWashington Maritime National Wildlife Refuge Complex) | Clallam County | WA | 1915 | 772.52 acres (3.1263 km2)[533] |
| Flattery Rocks National Wildlife Refuge (Part of theWashington Maritime National Wildlife Refuge Complex) | Clallam County | WA | 1907 | 125 acres (0.51 km2)[534] |
| Franz Lake National Wildlife Refuge | Skamania County | WA | 1990 | 551.73 acres (2.2328 km2)[535] |
| Grays Harbor National Wildlife Refuge | Grays Harbor County | WA | 1990 | 1,471.38 acres (5.9545 km2)[536] |
| Julia Butler Hansen Refuge for the Columbian White-Tailed Deer | Wahkiakum County Clatsop County, Oregon Columbia County, Oregon | WA | 1972 | 5,600 acres (23 km2)[434] |
| Little Pend Oreille National Wildlife Refuge | Pend Oreille County Stevens County | WA | 1939 | 42,593.57 acres (172.3701 km2)[537] |
| McNary National Wildlife Refuge | Walla Walla County | WA | 1956 | 14,664.54 acres (59.3453 km2)[538] |
| Pierce National Wildlife Refuge | Skamania County | WA | 1983 | 329.38 acres (1.3330 km2)[539] |
| Protection Island National Wildlife Refuge (Part of theWashington Maritime National Wildlife Refuge Complex) | Jefferson County | WA | 1982 | 659.31 acres (2.6681 km2)[488] |
| Quillayute Needles National Wildlife Refuge (Part of theWashington Maritime National Wildlife Refuge Complex) | Clallam County Jefferson County | WA | 1907 | 300.2 acres (1.215 km2)[540] |
| Ridgefield National Wildlife Refuge | Clark County | WA | 1965 | 5,228.1 acres (21.157 km2)[541] |
| Saddle Mountain National Wildlife Refuge/Hanford Reach National Monument | Adams County Benton County Franklin County Grant County | WA | 2000 | 194,451 acres (786.92 km2)[542] |
| San Juan Islands National Wildlife Refuge (Part of theWashington Maritime National Wildlife Refuge Complex) | San Juan County | WA | 1976 | 454 acres (1.84 km2)[543] |
| Steigerwald Lake National Wildlife Refuge | Clark County | WA | 1987 | 1,049 acres (4.25 km2)[544] |
| Toppenish National Wildlife Refuge | Yakima County | WA | 1964 | 1,978 acres (8.00 km2)[545] |
| Turnbull National Wildlife Refuge | Spokane County | WA | 1937 | 18,684.98 acres (75.6154 km2)[546] |
| Umatilla National Wildlife Refuge | Benton County Morrow County, Oregon | WA | 1969 | 23,783 acres (96.25 km2)[547] |
| Willapa National Wildlife Refuge | Pacific County | WA | 1937 | 11,000 acres (45 km2)[548] |
| Canaan Valley National Wildlife Refuge | Tucker County | WV | 11 July 1994 | 16,613.44 acres (67.2322 km2) |
| Ohio River Islands National Wildlife Refuge | Ohio River | WV | 1990 | 2,664.54 acres (10.7830 km2) |
| Driftless Area National Wildlife Refuge | Grant County Richland County Illinois Iowa | WI | 1989 | 812 acres (3.29 km2)[549] |
| Fox River National Wildlife Refuge | Marquette County | WI | 1979 | 1,054 acres (4.27 km2)[550] |
| Gravel Island National Wildlife Refuge | Door County | WI | 1913 | 28 acres (0.11 km2)[551] |
| Green Bay National Wildlife Refuge | Door County,Delta County, Michigan | WI | 1912 | 330 acres (1.3 km2)[552] |
| Hackmatack National Wildlife Refuge | Walworth County | WI | 2012 | 11 acres (0.045 km2)[553] |
| Horicon National Wildlife Refuge | Dodge County Fond du Lac County | WI | 1941 | 21,400 acres (87 km2)[554] |
| Leopold Wetland Management District | Southeastern Wisconsin | WI | 1993 | 13,000 acres (53 km2)[555] |
| Necedah National Wildlife Refuge | Juneau County | WI | 1939 | 43,696 acres (176.83 km2)[556] |
| St. Croix Wetland Management District | West Central Wisconsin | WI | 1992 | 7,500 acres (30 km2)[557] |
| Trempealeau National Wildlife Refuge | Buffalo County Trempealeau County | WI | 1936 | 6,226 acres (25.20 km2)[558] |
| Whittlesey Creek National Wildlife Refuge | Bayfield County | WI | 1999 | 329 acres (1.33 km2)[559] |
| Bamforth National Wildlife Refuge | Albany County | WY | 1932 | 1,116 acres (4.52 km2)[560] |
| Cokeville Meadows National Wildlife Refuge | Lincoln County | WY | 1993 | 26,657 acres (107.88 km2)[561] |
| Hutton Lake National Wildlife Refuge | Albany County | WY | 1932 | 1,968 acres (7.96 km2)[562] |
| Mortenson Lake National Wildlife Refuge | Albany County | WY | 1993 | 1,776 acres (7.19 km2)[563] |
| National Elk Refuge | Teton County | WY | 1912 | 25,000 acres (100 km2)[564] |
| Pathfinder National Wildlife Refuge | Carbon County Natrona County | WY | 1909 | 16,807 acres (68.02 km2)[565] |
| Seedskadee National Wildlife Refuge | Sweetwater County | WY | 1965 | 27,230 acres (110.2 km2)[566] |
| Navassa Island National Wildlife Refuge (Part of theCaribbean Islands National Wildlife Refuge Complex) | | UM | | |
| Baker Island National Wildlife Refuge (Managed under theHawaiian Islands National Wildlife Refuge) | | UM | | |
| Howland Island National Wildlife Refuge (Managed under theHawaiian Islands National Wildlife Refuge) | | UM | | |
| Jarvis Island National Wildlife Refuge (Managed under theHawaiian Islands National Wildlife Refuge) | | UM | | |
| Johnston Atoll National Wildlife Refuge (Managed under theHawaiian Islands National Wildlife Refuge) | | UM | | |
| Kingman Reef National Wildlife Refuge (Managed under theHawaiian Islands National Wildlife Refuge) | | UM | | |
| Palmyra Atoll National Wildlife Refuge (Managed under theHawaiian Islands National Wildlife Refuge) | | UM | | |
| Wake Atoll National Wildlife Refuge (Managed under theHawaiian Islands National Wildlife Refuge) | | UM | | |