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List of EC numbers (EC 6)

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This list contains alist ofEC numbers for the sixth group,EC 6,ligases, placed in numerical order as determined by the Nomenclature Committee of theInternational Union of Biochemistry and Molecular Biology. All official information is tabulated at the website of the committee.^[1] The database is developed and maintained by Andrew McDonald.^[2]

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1Oxidoreductases (list) EC2Transferases (list) EC3Hydrolases (list) EC4Lyases (list) EC5Isomerases (list) EC6Ligases (list) EC7Translocases (list)

v t e Enzymes: CO CS and CNligases (EC 6.1-6.3)
6.1: Carbon-Oxygen	Aminoacyl tRNA synthetase Alanine Arginine Asparagine Aspartate Cysteine D-Alanine—poly(phosphoribitol) ligase Glutamate Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine
6.2: Carbon-Sulfur	(2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase 2-furoate—CoA ligase 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate—CoA ligase 3-hydroxybenzoate—CoA ligase 3-hydroxypropionyl-CoA synthase 4-chlorobenzoate—CoA ligase 4-Coumarate-CoA ligase 4-hydroxybenzoate—CoA ligase 6-carboxyhexanoate—CoA ligase Acetate—ACP ligase Acetate—CoA ligase (ADP-forming) Acetoacetate—CoA ligase Acetyl—CoA synthetase Acid—CoA ligase (GDP-forming) Anthranilate—CoA ligase Arachidonate—CoA ligase Benzoate—CoA ligase Biotin—CoA ligase (butirosin acyl-carrier protein)—L-glutamate ligase Butyrate—CoA ligase Cholate—CoA ligase Citrate—CoA ligase (citrate (pro-3S)-lyase) ligase Dicarboxylate—CoA ligase Glutarate—CoA ligase Long-chain-fatty-acid—ACP ligase Long-chain-fatty-acid—CoA ligase Malate—CoA ligase Malonate—CoA ligase o-Succinylbenzoate—CoA ligase Oxalate—CoA ligase Phenylacetate—CoA ligase Phytanate—CoA ligase Propionate—CoA ligase Succinate—CoA ligase (ADP-forming) Succinate—CoA ligase (GDP-forming) Succinyl—CoA synthetase trans-Feruloyl—CoA synthase
6.3: Carbon-Nitrogen	Glutamine synthetase Ubiquitin ligase Cullin Von Hippel–Lindau tumor suppressor UBE3A Mdm2 Anaphase-promoting complex UBR1 Glutathione synthetase CTP synthetase Adenylosuccinate synthase Argininosuccinate synthase Holocarboxylase synthetase GMP synthase Asparagine synthetase Carbamoyl phosphate synthetase I II Glutamate–cysteine ligase

v t e Ligases: carbon-carbon ligases (EC 6.4)
Biotin dependentcarboxylation	Pyruvate carboxylase Acetyl-CoA carboxylase Propionyl-CoA carboxylase Methylcrotonyl-CoA carboxylase
Other	Polyketide synthase

v t e Enzymes: Phosphoric ester and nitrogen-metalligases (EC 6.5-6.6)
6.5: Phosphoric Ester	DNA ligase
6.6: Nitrogen-Metal	Magnesium chelatase Cobalt chelatase

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EC 6.1: Forming Carbon-Oxygen Bonds

EC 6.1.1: Ligases Forming Aminoacyl-tRNA and Related Compounds (Aminoacyl tRNA synthetase)

EC 6.1.2: Acid—alcohol ligases (ester synthases)

EC 6.1.3: Cyclo-ligases

EC 6.2: Forming Carbon-Sulfur Bonds

EC 6.2.1: Acid-Thiol Ligases

EC 6.2.2: Amide—thiol ligases

EC 6.3: Forming Carbon-Nitrogen Bonds

EC 6.3.1: Acid—Ammonia (or Amine) Ligases (Amide Synthases)

EC 6.3.2: Acid—Amino-Acid Ligases (Peptide Synthases)

EC 6.3.3: Cyclo-Ligases

EC 6.3.4: Other Carbon-Nitrogen Ligases

EC 6.3.5: Carbon-nitrogen ligases with glutamine as amido-N-donor

EC 6.4: Forming Carbon-Carbon Bonds

EC 6.4.1: Ligases that form carbon-carbon bonds (only sub-subclass identified to date)

EC 6.5: Forming Phosphoric Ester Bonds

EC 6.5.1: Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)

EC 6.6: Forming Nitrogen-Metal Bonds

EC 6.6.1: Forming Coordination Complexes

EC 6.7: Forming nitrogen-nitrogen bonds

EC 6.7.1: Forming diazo bonds

References