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Lisa M. Boulanger | |
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 Boulanger speaks at the 2016World Economic Forum | |
| Born | 1969 (age 56–57) |
| Alma mater | University of California, San Diego |
| Scientific career | |
| Institutions | Princeton University Harvard Medical School University of California, San Diego |
| Thesis | Activity-dependent regulation of the synaptic action of neurotrophin (1998) |
| Website | Boulanger Lab |
Lisa Boulanger is an American neuroscientist and who is a professor atPrinceton University. Her research considers immune proteins in the formation and function of neuronal connectivity.
Boulanger was a doctoral researcher at theUniversity of California, San Diego, where she worked underMu-ming Poo.[1][2] Her research considered regulation of the synaptic action ofneurotrophin.[1] Afterward she was a postdoctoral researcher atHarvard Medical School withCarla J. Shatz.[2]
Boulanger leftHarvard Medical School to start her independent scientific career at theUniversity of California, San Diego. She was made the Silvio Varon Professor of Neuroregeneration. She moved her laboratory toPrinceton University in 2009.[2]
Boulanger investigates how immune systems proteins are involved in brain development. She has extensively investigatedmajor histocompatibility complex proteins, which enableT cells to destroy infected cancerous cells. It was originally understood that neurons were not visible to the immune system because they lackedMHC class I, but Boulanger has shown that healthy neurons can express MHC class I, and that this expression is regulated by electrical activity.[3] She has shown thatmajor histocompatibility complex proteins are involved in other, non-immune-related brain functions.[3] In the adult hippocampus, major histocompatibility complex proteins are required forlong-term potentiation.[3] She makes use ofpatch clamp andelectrophysiology, and the expression of MHC class Iin vivo andin vitro.[3]
Boulanger has started investigating the efficacy of viruses that are used to treatnervous system disorders.[4] These includeadeno-associated virus, a virus in which viral genes are removed and replaced with more therapeutic genes. She noticed that these viruses can still change the structure of neural circuitry.[4]
Authority control databases: Academics |
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