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Leukotriene D₄

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Leukotriene D₄
Names

Systematic IUPAC name (5S,6R,7E,9E,11Z,14Z)-6-({(2R)-2-Amino-3-[(carboxymethyl)amino]-3-oxopropyl}sulfanyl)-5-hydroxyicosa-7,9,11,14-tetraenoic acid
Identifiers
CAS Number	73836-78-9^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:28666^N
ChEMBL	ChEMBL288943^N
ChemSpider	4444401^N
MeSH	Leukotriene+D4
PubChem CID	5280878
UNII	5FNY4416UE^Y
CompTox Dashboard(EPA)	DTXSID6040533
InChI InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1^N Key: YEESKJGWJFYOOK-IJHYULJSSA-N^N InChI=1/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 Key: YEESKJGWJFYOOK-IJHYULJSBX
SMILES CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O
Properties
Chemical formula	C₂₅H₄₀N₂O₆S
Molar mass	496.66 g·mol⁻¹
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references

Chemical compound

Leukotriene D₄ (LTD₄) is one of theleukotrienes. Its main function in the body is to induce thecontraction of smooth muscle, resulting inbronchoconstriction andvasoconstriction. It also increasesvascular permeability. LTD₄ is released bybasophils. Other leukotrienes that function in a similar manner are leukotrienesC₄ andE₄. Pharmacological agents that inhibit the function of these leukotrienes areleukotriene receptor antagonists (e.g.,zafirlukast,montelukast) and are useful forasthmatic individuals.^[1]

Precursor

Precursor

Active

D/J	D₂
E/F	E₂ (Dinoprostone) E₁ (Alprostadil) F_2α (Dinoprost):
I	I₂ (Prostacyclin/Epoprostenol):

Precursor	Arachidonic acid 5-hydroperoxide
Initial	A₄ B₄
SRS-A	C₄ D₄ E₄

Precursor	Arachidonic acid 15-hydroperoxide
Eoxins	A₄ C₄ D₄ E₄

By function

BLTTooltip Leukotriene B4 receptor

BLT₁Tooltip Leukotriene B4 receptor 1	Agonists:12-HETE 20-Hydroxy-LTB₄ Leukotriene B₄ LY-255283 Antagonists:20-Carboxy-LTB₄ Amelubant CGS-23131 (LY-223982) CGS-25019C CP-105696 CP-195543 Etalocib LY-293111 Moxilubant ONO-4057 RG-14893 RP-69698 SB-209247 SC-53228 Ticolubant U-75302 ZK-158252
BLT₂Tooltip Leukotriene B4 receptor 2	Agonists:12-HETE 12-HHT 12-HpETE 15-HETE 15-HpETE 20-Hydroxy-LTB₄ Leukotriene B₄ Antagonists:CP-195543 LY-255283 ZK-158252

CysLTTooltip Cysteinyl leukotriene receptor

CysLT₁Tooltip Cysteinyl leukotriene receptor 1	Agonists:Leukotriene C₄ Leukotriene D₄ Leukotriene E₄ Antagonists:Ablukast BAYu9773 BAYu9916 BAYx7195 Cinalukast FPL-55712 ICI-198615 Iralukast LY-170680 Masilukast MK-571 Montelukast ONO-1078 Pobilukast Pranlukast Ritolukast SKF-104353 SR-2640 Sulukast Tipelukast Tomelukast Verlukast Zafirlukast ZD-3523 Gemilukast Quinotolast
CysLT₂Tooltip Cysteinyl leukotriene receptor 2	Agonists:Leukotriene C₄ Leukotriene D₄ Leukotriene E₄ Antagonists:BAYu9773 BAYu9916
CysLT_ETooltip Cysteinyl leukotriene receptor E	Agonists:Leukotriene E₄

5-LOXTooltip Arachidonate 5-lipoxygenase	2-TEDC Baicalein BW-A4C BW-B70C Caffeic acid CDC CJ-13610 Curcumin Fenleuton Hyperforin Hypericum perforatum (St. John's Wort) Meclofenamic acid (meclofenamate) Minocycline N-Stearoyldopamine Timegadine Zileuton FLAPTooltip Arachidonate 5-lipoxygenase-activating protein inhibitors:AM-103 AM-679 BAYx1005 MK-591 MK-886
12-LOXTooltip Arachidonate 12-lipoxygenase	2-TEDC 3-Methoxytropolone Baicalein CDC
15-LOXTooltip Arachidonate 15-lipoxygenase	2-TEDC CDC Luteolin PD-146176
LTA₄HTooltip Leukotriene A4 hydrolase	Acebilustat Captopril DG-051 Fosinoprilat JNJ-26993135 SA-6541 SC-57461A Ubenimex (bestatin)
LTB₄HTooltip Leukotriene B4 ω-hydroxylase	17-Octadecynoic acid
LTC₄STooltip Leukotriene C4 synthase	Azelastine MK-886
LTC₄HTooltip Leukotriene C4 hydrolase	Acivicin Serine-borate complex
LTD₄Tooltip Leukotriene D4 hydrolase	Cilastatin Ubenimex (bestatin)

Others

See also: Receptor/signaling modulators; Prostanoid signaling modulators

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