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| Preferred IUPAC name (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxyicosa-6,8,10,14-tetraenoic acid | |
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3D model (JSmol) | |
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| Properties | |
| C20H32O4 | |
| Molar mass | 336.472 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Leukotriene B4 (LTB4) is aleukotriene involved ininflammation. It has been shown to promote insulin resistance in obese mice.
LTB4 is a leukotriene involved ininflammation. It is produced fromleukocytes in response to inflammatory mediators and is able to induce the adhesion and activation of leukocytes on theendothelium, allowing them to bind to and cross it into the tissue.[1] Inneutrophils, it is also a potentchemoattractant, and is able to induce the formation ofreactive oxygen species and the release oflysosomal enzymes by these cells.[1] It is synthesized byleukotriene-A4 hydrolase fromleukotriene A4.[2]
A study at the University of California, San Diego School of Medicine has shown that LTB4 promotesinsulin resistance in obese mice.[3]Obesity is the major cause of insulin resistance intype 2 diabetes.[4]
