 | |
| Names | |
|---|---|
| IUPAC name Abieta-8,11,13-trien-18-amine | |
| Systematic IUPAC name 1-[(1R,4aS,10aR)-1,4a-Dimethyl-7-(propan-2-yl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl]methanamine | |
| Other names (+)-Dehydroabietylamine; Amine D | |
| Identifiers | |
3D model (JSmol) | |
| ChemSpider | |
| ECHA InfoCard | 100.014.454 |
| UNII | |
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| Properties | |
| C20H31N | |
| Molar mass | 285.475 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Leelamine (dehydroabietylamine) is aditerpeneamine that has weak affinity for thecannabinoid receptorsCB1 andCB2, as well as being an inhibitor ofpyruvate dehydrogenase kinase.[1]Optically active leelamine is also used as achiral resolving agent for carboxylic acids.[2][3] Leelamine has been shown to be effective against certain cancer cells, independent from its activity on CB receptors or PDK1 - it accumulates inside the acidic lysosomes leading to disruption of intracellular cholesterol transport, autophagy and endocytosis followed by cell death.[4]
 | Thiscannabinoid related article is astub. You can help Wikipedia byadding missing information. |
