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Lavoltidine

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Lavoltidine
Clinical data
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
  • Development terminated
Identifiers
  • [1-methyl-5-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]-1,2,4-triazol-3-yl]methanol
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC19H29N5O2
Molar mass359.474 g·mol−1
3D model (JSmol)
  • OCc1nn(C)c(n1)NCCCOc2cccc(c2)CN3CCCCC3

Lavoltidine (INN,[1]USAN,BAN; previously known asloxtidine; development codeAH-23,844) is a highlypotent andselectiveH2 receptorantagonist which was under development by Glaxo Wellcome (nowGlaxoSmithKline)[2] as a treatment forgastroesophageal reflux disease but was discontinued due to the discovery that it producedgastric carcinoid tumors in rodents.[3][4]

See also

[edit]

References

[edit]
  1. ^"International Nonproprietary Names for Pharmaceutical Substances. Recommended International Nonproprietary Names (Rec. INN): List 30"(PDF).WHO Drug Information.4 (3). World Health Organization: 7. 1990. Retrieved12 January 2016.
  2. ^"Drug Profile: Lavoltidine".AdisInsight. Springer International Publishing AG. Retrieved12 January 2016.
  3. ^Washington N (1991).Antacids and anti-reflux agents. Boca Raton: CRC Press.ISBN 0-8493-5444-7.
  4. ^Dictionary of organic compounds. London: Chapman & Hall. 1996.ISBN 0-412-54090-8.
H2 antagonists ("-tidine")
Prostaglandins (E)/
analogues ("-prost-")
Proton-pump inhibitors
("-prazole")
Potassium-competitive
acid blockers
("-prazan")
Others
Combinations
H1
Agonists
Antagonists
H2
Agonists
Antagonists
H3
Agonists
Antagonists
H4
Agonists
Antagonists
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