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LZTS1

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

LZTS1

Identifiers

Aliases

LZTS1, F37, FEZ1, leucine zipper, putative tumor suppressor 1, leucine zipper tumor suppressor 1

External IDs

OMIM:606551;MGI:2684762;HomoloGene:10873;GeneCards:LZTS1;OMA:LZTS1 - orthologs

Gene location (Human)

Chr.	Chromosome 8 (human)^[1]

Band	8p21.3	Start	20,246,165bp^[1]
Band	8p21.3	End	20,303,963bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8\|8 B3.3	Start	69,585,321bp^[2]
Band	8\|8 B3.3	End	69,636,877bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

nucleus accumbens

Brodmann area 23

primary visual cortex

right frontal lobe

caudate nucleus

Amygdala

prefrontal cortex

putamen

dorsolateral prefrontal cortex

Top expressed in

olfactory tubercle

piriform cortex

dorsal striatum

Rostral migratory stream

Region I of hippocampus proper

lumbar spinal ganglion

lateral septal nucleus

superior frontal gyrus

nucleus accumbens

primary motor cortex

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	DNA binding DNA-binding transcription factor activity protein binding microtubule binding
Cellular component	cytoplasm postsynaptic membrane cell projection membrane postsynaptic density plasma membrane dendritic spine synapse cell junction apical plasma membrane neuron projection dendritic shaft cell body
Biological process	negative regulation of macroautophagy transcription, DNA-templated cell cycle regulation of transcription, DNA-templated mitotic cell cycle phase transition regulation of synaptic plasticity regulation of dendrite morphogenesis
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


11178


211134

Ensembl


ENSG00000061337


ENSMUSG00000036306

UniProt


Q9Y250


P60853

RefSeq (mRNA)


NM_021020 NM_001362884


NM_199364 NM_001370971

RefSeq (protein)


NP_066300 NP_001349813


NP_955396 NP_001357900

Location (UCSC)

Chr 8: 20.25 – 20.3 Mb

Chr 8: 69.59 – 69.64 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Leucine zipper putative tumor suppressor 1 is aprotein that, in humans, is encoded by theLZTS1gene.^[5]^[6]^[7]

In melanocytic cells LZTS1 gene expression may be regulated byMITF.^[8]

Interactions

[edit]

LZTS1 has been shown tointeract withEEF1G.^[9]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000061337 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000036306 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ishii H, Baffa R, Numata SI, Murakumo Y, Rattan S, Inoue H, Mori M, Fidanza V, Alder H, Croce CM (May 1999)."The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors".Proc Natl Acad Sci U S A.96 (7):3928–33.Bibcode:1999PNAS...96.3928I.doi:10.1073/pnas.96.7.3928.PMC 22397.PMID 10097140.
^Vecchione A, Baldassarre G, Ishii H, Nicoloso MS, Belletti B, Petrocca F, Zanesi N, Fong LY, Battista S, Guarnieri D, Baffa R, Alder H, Farber JL, Donovan PJ, Croce CM (Mar 2007)."Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development".Cancer Cell.11 (3):275–89.doi:10.1016/j.ccr.2007.01.014.PMC 1987708.PMID 17349584.
^"Entrez Gene: LZTS1 leucine zipper, putative tumor suppressor 1".
^Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008)."Novel MITF targets identified using a two-step DNA microarray strategy".Pigment Cell Melanoma Res.21 (6):665–76.doi:10.1111/j.1755-148X.2008.00505.x.PMID 19067971.S2CID 24698373.
^Ishii H, Vecchione A, Murakumo Y, Baldassarre G, Numata S, Trapasso F, Alder H, Baffa R, Croce CM (Aug 2001)."FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis".Proc. Natl. Acad. Sci. U.S.A.98 (18):10374–9.Bibcode:2001PNAS...9810374I.doi:10.1073/pnas.181222898.PMC 56968.PMID 11504921.

Ono K, Uzawa K, Nakatsuru M, Shiiba M, Mochida Y, Tada A, Bukawa H, Miyakawa A, Yokoe H, Tanzawa H (2004). "Down-regulation of FEZ1/LZTS1 gene with frequent loss of heterozygosity in oral squamous cell carcinomas".Int. J. Oncol.23 (2):297–302.doi:10.3892/ijo.23.2.297.PMID 12851677.
Hawkins GA, Mychaleckyj JC, Zheng SL, Faith DA, Kelly B, Isaacs SD, Wiley KE, Chang BL, Ewing CM, Bujnovszky P, Bleecker ER, Walsh PC, Meyers DA, Isaacs WB, Xu J (2002). "Germline sequence variants of the LZTS1 gene are associated with prostate cancer risk".Cancer Genet. Cytogenet.137 (1):1–7.doi:10.1016/S0165-4608(02)00549-6.PMID 12377406.
Ishii H, Vecchione A, Murakumo Y, Baldassarre G, Numata S, Trapasso F, Alder H, Baffa R, Croce CM (2001)."FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis".Proc. Natl. Acad. Sci. U.S.A.98 (18):10374–9.Bibcode:2001PNAS...9810374I.doi:10.1073/pnas.181222898.PMC 56968.PMID 11504921.
Cabeza-Arvelaiz Y, Sepulveda JL, Lebovitz RM, Thompson TC, Chinault AC (2001). "Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22".Oncogene.20 (31):4169–79.doi:10.1038/sj.onc.1204539.PMID 11464283.S2CID 38760860.

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