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LY-235959

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
LY-235959
Identifiers
  • (3S,4aR,6S,8aR)-6-(phosphonomethyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC11H20NO5P
Molar mass277.257 g·mol−1
3D model (JSmol)
  • [H][C@]12[C@](CC[C@H](CP(O)(O)=O)C2)([H])CN[C@H](C(O)=O)C1
  • InChI=1S/C11H20NO5P/c13-11(14)10-4-9-3-7(6-18(15,16)17)1-2-8(9)5-12-10/h7-10,12H,1-6H2,(H,13,14)(H2,15,16,17)/t7-,8-,9+,10-/m0/s1
  • Key:STIRHCNEGQQBOY-QEYWKRMJSA-N

LY-235959 is a competitiveantagonist at theNMDA receptor.[1] It hasanalgesic andneuroprotective effects and causeshypothermia in animal models,[2] as well as reducing the development of tolerance to morphine and altering the reinforcing effects of cocaine.[3][4][5][6][7]

References

[edit]
  1. ^Allen RM, Dykstra LA (July 2001). "N-methyl-D-aspartate receptor antagonists potentiate the antinociceptive effects of morphine in squirrel monkeys".The Journal of Pharmacology and Experimental Therapeutics.298 (1):288–97.PMID 11408554.
  2. ^Rawls SM, Cowan A, Tallarida RJ, Geller EB, Adler MW (October 2002). "N-methyl-D-aspartate antagonists and WIN 55212-2 [4,5-dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1-i,j]quinolin-6-one], a cannabinoid agonist, interact to produce synergistic hypothermia".The Journal of Pharmacology and Experimental Therapeutics.303 (1):395–402.doi:10.1124/jpet.102.037473.PMID 12235276.S2CID 18307764.
  3. ^Allen RM, Carelli RM, Dykstra LA, Suchey TL, Everett CV (October 2005). "Effects of the competitive N-methyl-D-aspartate receptor antagonist, LY235959 [(-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid], on responding for cocaine under both fixed and progressive ratio schedules of reinforcement".The Journal of Pharmacology and Experimental Therapeutics.315 (1):449–57.doi:10.1124/jpet.105.086355.PMID 16024734.S2CID 15151429.
  4. ^Allen RM, Dykstra LA, Carelli RM (April 2007). "Continuous exposure to the competitive N-methyl-D: -aspartate receptor antagonist, LY235959, facilitates escalation of cocaine consumption in Sprague-Dawley rats".Psychopharmacology.191 (2):341–51.doi:10.1007/s00213-006-0661-3.PMID 17225167.S2CID 20887004.
  5. ^Fischer BD, Ward SJ, Henry FE, Dykstra LA (February 2010)."Attenuation of morphine antinociceptive tolerance by a CB(1) receptor agonist and an NMDA receptor antagonist: Interactive effects".Neuropharmacology.58 (2):544–50.doi:10.1016/j.neuropharm.2009.08.005.PMC 2813317.PMID 19699755.
  6. ^Dykstra LA, Fischer BD, Balter RE, Henry FE, Schmidt KT, Miller LL (September 2011)."Opioid antinociception, tolerance and dependence: interactions with the N-methyl-D-aspartate system in mice".Behavioural Pharmacology.22 (5–6):540–7.doi:10.1097/FBP.0b013e328348ed08.PMC 3155647.PMID 21712708.
  7. ^Bicca MA, Figueiredo CP, Piermartiri TC, Meotti FC, Bouzon ZL, Tasca CI, et al. (September 2011). "The selective and competitive N-methyl-D-aspartate receptor antagonist, (-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid, prevents synaptic toxicity induced by amyloid-β in mice".Neuroscience.192:631–41.doi:10.1016/j.neuroscience.2011.06.038.PMID 21756976.S2CID 36154501.
AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
KARTooltip Kainate receptor
NMDARTooltip N-Methyl-D-aspartate receptor
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