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LPAR3

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
LPAR3
Identifiers
AliasesLPAR3, EDG7, Edg-7, GPCR, HOFNH30, LP-A3, LPA3, RP4-678I3, lysophosphatidic acid receptor 3
External IDsOMIM:605106;MGI:1929469;HomoloGene:8123;GeneCards:LPAR3;OMA:LPAR3 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for LPAR3
Genomic location for LPAR3
Band1p22.3Start84,811,602bp[1]
End84,893,206bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for LPAR3
Genomic location for LPAR3
Band3 H2|3 71.03 cMStart145,926,718bp[2]
End145,991,941bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bronchial epithelial cell

  • right uterine tube

  • mucosa of paranasal sinus

  • spinal ganglia

  • olfactory zone of nasal mucosa

  • trigeminal ganglion

  • atrium

  • right auricle

  • myocardium

  • cardiac muscle tissue of right atrium
Top expressed in
  • lumbar spinal ganglion

  • endocardial cushion

  • right kidney

  • membranous bone

  • Dermatocranium

  • maxilla

  • mandible

  • vestibular membrane of cochlear duct

  • atrioventricular junction

  • atrioventricular valve
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23566

65086

Ensembl

ENSG00000171517

ENSMUSG00000036832

UniProt

Q9UBY5

Q9EQ31

RefSeq (mRNA)

NM_012152

NM_022983

RefSeq (protein)

NP_036284

NP_075359

Location (UCSC)Chr 1: 84.81 – 84.89 MbChr 3: 145.93 – 145.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lysophosphatidic acid receptor 3 also known asLPA3 is aprotein in humans that is encoded by theLPAR3gene.[5][6] LPA3 is aG protein-coupled receptor that binds the lipid signaling moleculelysophosphatidic acid (LPA).[7]

Function

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This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.[5]

Evolution

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Paralogues

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Source:[8]

See also

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References

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  1. ^abcGRCh38: Ensembl release 89: ENSG00000171517Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000036832Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ab"Entrez Gene: LPAR3 Lysophosphatidic acid receptor 3".
  6. ^Bandoh K, Aoki J, Hosono H, Kobayashi S, Kobayashi T, Murakami-Murofushi K, Tsujimoto M, Arai H, Inoue K (September 1999)."Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid".J. Biol. Chem.274 (39):27776–85.doi:10.1074/jbc.274.39.27776.PMID 10488122.
  7. ^Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions".Annual Review of Pharmacology and Toxicology.50 (1):157–186.doi:10.1146/annurev.pharmtox.010909.105753.PMID 20055701.
  8. ^"GeneCards®: The Human Gene Database".

Further reading

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External links

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This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

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