Protein-coding gene in the species Homo sapiens
Serine/threonine-protein kinase LMTK2 also known asLemur tyrosine kinase 2 (LMTK2) is anenzyme that in humans is encoded by theLMTK2 gene .[ 5] [ 6]
The LMTK2 enzyme belongs to both theprotein kinase and thetyrosine kinase families. It containsN-terminus transmembrane helices and a longC-terminal cytoplasmic tail with serine/threonine kinase activity. This protein interacts with several other proteins, such as androgen receptor, inhibitor-2 (Inh2), protein phosphatase-1 (PP1C ),p35 , andmyosin VI . Itphosphorylates other proteins, and is itself also phosphorylated when interacting with cyclin-dependent kinase 5 (cdk5 )/p35 complex. This protein is involved in nerve growth factor (NGF )-TrkA signalling, and also plays a critical role inendosomal membranetrafficking . Mouse studies suggested an essential role of this protein inspermatogenesis .[ 6]
Clinical significance [ edit ] Loss of LMTK2 has been implicated to play a role in development ofprostate cancer .[ 7]
LMTK2 has been shown tointeract withPPP1CA ,[ 8] Cyclin-dependent kinase 5 [ 9] PPP1R2 .[ 8]
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