Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILR-A5) also known asCD85 antigen-like family member G (CD85g), andimmunoglobulin-like transcript 7 (ILT-7) is aprotein that in humans is encoded by theLILRA4gene.[3][4]
This gene encodes an immunoglobulin-like cell surface protein preferentially expressed in plasmacytoid dendritic cells (PDCs). This gene is highly expressed in PDCs, and is found to be rapidly down-regulated by interleukin 3 (IL3). This gene is one of the 19 highly related genes that form aleukocyte immunoglobulin-like receptor gene cluster (LRC) at chromosomal region 19q13.4.[4]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wende H, Volz A, Ziegler A (Sep 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster".Immunogenetics.51 (8–9):703–13.doi:10.1007/s002510000187.PMID10941842.S2CID20719684.
Cho M, Ishida K, Chen J, et al. (2008). "SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production".Int. Immunol.20 (1):155–64.doi:10.1093/intimm/dxm127.PMID18048391.
Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry".Anal. Biochem.354 (2):279–89.doi:10.1016/j.ab.2006.05.024.PMID16777052.
Ju XS, Hacker C, Scherer B, et al. (2004). "Immunoglobulin-like transcripts ILT2, ILT3 and ILT7 are expressed by human dendritic cells and down-regulated following activation".Gene.331:159–64.doi:10.1016/j.gene.2004.02.018.PMID15094202.
Young NT, Canavez F, Uhrberg M, et al. (2001). "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex".Immunogenetics.53 (4):270–8.doi:10.1007/s002510100332.PMID11491530.S2CID2819935.
