LHX3 encodes a protein of a large protein family, members of which carry theLIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required forpituitary development andmotor neuron specification. Two transcript variants encoding distinct isoforms have been identified for this gene.[7]
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Schmitt S, Biason-Lauber A, Betts D, Schoenle EJ (2000). "Genomic structure, chromosomal localization, and expression pattern of the human LIM-homeobox3 (LHX 3) gene".Biochem. Biophys. Res. Commun.274 (1):49–56.Bibcode:2000BBRC..274...49S.doi:10.1006/bbrc.2000.3038.PMID10903894.
Ostendorff HP, Peirano RI, Peters MA, Schlüter A, Bossenz M, Scheffner M, Bach I (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors".Nature.416 (6876):99–103.Bibcode:2002Natur.416...99O.doi:10.1038/416099a.PMID11882901.S2CID4426785.
van Meyel DJ, Thomas JB, Agulnick AD (2003). "Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo".Development.130 (9):1915–25.doi:10.1242/dev.00389.PMID12642495.S2CID6211268.
Kim SS, Kim Y, Shin YL, Kim GH, Kim TU, Yoo HW (2004). "Clinical characteristics and molecular analysis of PIT1, PROP1, LHX3, and HESX1 in combined pituitary hormone deficiency patients with abnormal pituitary MR imaging".Horm. Res.60 (6):277–83.doi:10.1159/000074245.PMID14646405.S2CID31256955.
Dattani MT (2004). "Borjeson-Forssman-Lehmann syndrome: a novel pituitary phenotype due to mutation in a novel gene".J. Pediatr. Endocrinol. Metab.16 (9):1207–9.doi:10.1515/jpem.2003.16.9.1207.PMID14714741.S2CID45542882.
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Sobrier ML, Attié-Bitach T, Netchine I, Encha-Razavi F, Vekemans M, Amselem S (2006). "Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development".Gene Expr. Patterns.5 (2):279–84.doi:10.1016/j.modgep.2004.07.003.PMID15567726.
