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LATS2

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
LATS2
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

4ZRI

Identifiers
AliasesLATS2, KPM, large tumor suppressor kinase 2
External IDsOMIM:604861;MGI:1354386;HomoloGene:56678;GeneCards:LATS2;OMA:LATS2 - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for LATS2
Genomic location for LATS2
Band13q12.11Start20,973,036bp[1]
End21,061,586bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for LATS2
Genomic location for LATS2
Band14|14 C3Start57,927,119bp[2]
End57,995,845bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pancreatic epithelial cell

  • myocardium of left ventricle

  • visceral pleura

  • parietal pleura

  • tibialis anterior muscle

  • tibia

  • germinal epithelium

  • cardiac muscle tissue of right atrium

  • lower lobe of lung

  • amniotic fluid
Top expressed in
  • ascending aorta

  • aortic valve

  • external carotid artery

  • sciatic nerve

  • cardiac muscle tissue of left ventricle

  • internal carotid artery

  • spermatid

  • left lung lobe

  • plantaris muscle

  • carotid body
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26524

50523

Ensembl

ENSG00000150457

ENSMUSG00000021959

UniProt

Q9NRM7

Q7TSJ6

RefSeq (mRNA)

NM_014572

NM_015771
NM_153382

RefSeq (protein)

NP_055387

NP_056586
NP_700431

Location (UCSC)Chr 13: 20.97 – 21.06 MbChr 14: 57.93 – 58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Large tumor suppressor kinase 2 (LATS2) is anenzyme that in humans is encoded by theLATS2gene.[5][6]

This gene encodes aserine/threonine protein kinase belonging to the LATStumor suppressor family and participates in theHippo signaling pathway where it inactivates the effector proteins, YAP andWWTR1 (TAZ). The protein localizes tocentrosomes duringinterphase and early and latemetaphase. It interacts with the centrosomal proteinsaurora-A andajuba and is required for accumulation ofgamma-tubulin andspindle formation at the onset ofmitosis. It also interacts with anegative regulator ofp53 and may function in apositive feedback loop with p53 that responds tocytoskeleton damage. Additionally, it can function as acorepressor ofandrogen-responsive gene expression.[6]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000150457Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000021959Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H (Apr 2000). "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts".Genomics.63 (2):263–70.doi:10.1006/geno.1999.6065.PMID 10673337.
  6. ^ab"Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)".

Further reading

[edit]
Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
Activity
Regulation
Classification
Kinetics
Types
Portal:


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