LAMP3 also known asDC-LAMP (Dendritic cell lysosomal associated membrane glycoprotein) is a member of the LAMP family along withLAMP1 andLAMP2, these proteins make up the members of the glycoconjugate coat present on the inside of the lysosomal membrane.[7] In humans, this protein is almost exclusively found in matureDendritic cells. While LAMP3 can be observed on the surface of dendritic cells, the protein is mainly found within lysosomes. LAMP3 first appears in theMHC Class II compartment and in cells aids in the identifying and processing of an antigen during an immune response.[8][9] LAMP3 protein is linked with the maturation of dendritic cells, and as a marker for transformed type II pneumocytes oralveolar cells.[10]
Studies have linked LAMP3 with the inhibition of the viral replication ofInfluenza A cells.[11]
LAMP3 is a Type I integral membrane protein consisting of about 416 amino acid residues with about 90% of the protein located within the lumen of the lysosomes.[9] LAMP3 has been shown to be highly expressed in dendritic cells during cell differentiation and maturation.[7] During human fetal development, between weeks 10 and 20, LAMP3 is highly expressed in the lungs, while in normal adult tissue cells LAMP3 is expressed in the lungs, appendix, testis and lymph nodes.[12]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ozaki K, Nagata M, Suzuki M, Fujiwara T, Ueda K, Miyoshi Y, Takahashi E, Nakamura Y (Sep 1998). "Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoproteins 1 and 2: significantly increased expression in cancers of various tissues".Cancer Res.58 (16):3499–503.PMID9721848.
^abMalaguarnera L, Marsullo A, Zorena K, Musumeci G, Di Rosa M (2017). "Vitamin D3 regulates LAMP3 expression in monocyte derived dendritic cells".Cell Immunol.311:13–21.doi:10.1016/j.cellimm.2016.09.013.PMID27697285.
Akasaki K, Nakamura N, Tsukui N, et al. (2004). "Human dendritic cell lysosome-associated membrane protein expressed in lung type II pneumocytes".Arch. Biochem. Biophys.425 (2):147–57.doi:10.1016/j.abb.2004.02.042.PMID15111122.
Overview of all the structural information available in thePDB forUniProt:Q9UQV4 (Human Lysosome-associated membrane glycoprotein 3 (LAMP3)) at thePDBe-KB.
