Leukocyte-associated immunoglobulin-like receptor 2 is aprotein that in humans is encoded by theLAIR2gene.[3][4]
The protein encoded by this gene is a member of theimmunoglobulin superfamily. It was identified by its similarity toLAIR1, an inhibitory receptor present onmononuclear leukocytes. This gene maps to a region of19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. The function of this protein is unknown, although it is thought to be secreted and may help modulatemucosal tolerance. Twotranscript variants encoding differentisoforms have been found for this gene.[4]
Wende H, Volz A, Ziegler A (2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster".Immunogenetics.51 (8–9):703–13.doi:10.1007/s002510000187.PMID10941842.S2CID20719684.
Meyaard L, Hurenkamp J, Clevers H, Lanier LL, Phillips JH (1999). "Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells".J. Immunol.162 (10):5800–4.doi:10.4049/jimmunol.162.10.5800.PMID10229813.
