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L-AP4

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
L-AP4
Clinical data
Other namesL-2-Amino-4-phosphonobutyric acid
Identifiers
  • (2S)-2-Amino-4-phosphonobutanoic acid
CAS Number
PubChemCID
IUPHAR/BPS
ChemSpider
UNII
CompTox Dashboard(EPA)
ECHA InfoCard100.164.384Edit this at Wikidata
Chemical and physical data
FormulaC4H10NO5P
Molar mass183.100 g·mol−1
3D model (JSmol)
  • C(CP(=O)(O)O)[C@@H](C(=O)O)N
  • InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1 ☒N
  • Key:DDOQBQRIEWHWBT-VKHMYHEASA-N ☒N
 ☒NcheckY (what is this?)  (verify)

L-AP4 (L-2-amino-4-phosphonobutyric acid) is a drug used in scientific research, which acts as a group-selectiveagonist for the group IIImetabotropic glutamate receptors (mGluR4/6/7/8). It was the first ligand found to act as an agonist selective for this group of mGlu receptors,[1] but does not show selectivity between the different mGluR Group III subtypes. It is widely used in the study of this receptor family and their various functions.[2][3][4][5]

References

[edit]
  1. ^Thomsen C (August 1997). "The L-AP4 receptor".General Pharmacology.29 (2):151–8.doi:10.1016/S0306-3623(96)00417-X.PMID 9251893.
  2. ^Lopez S, Turle-Lorenzo N, Acher F, De Leonibus E, Mele A, Amalric M (June 2007)."Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease".The Journal of Neuroscience.27 (25):6701–11.doi:10.1523/JNEUROSCI.0299-07.2007.PMC 6672706.PMID 17581957.
  3. ^Macinnes N, Duty S (February 2008). "Group III metabotropic glutamate receptors act as hetero-receptors modulating evoked GABA release in the globus pallidus in vivo".European Journal of Pharmacology.580 (1–2):95–9.doi:10.1016/j.ejphar.2007.10.030.PMID 18035348.
  4. ^Zhang HM, Chen SR, Pan HL (January 2009)."Effects of activation of group III metabotropic glutamate receptors on spinal synaptic transmission in a rat model of neuropathic pain".Neuroscience.158 (2):875–84.doi:10.1016/j.neuroscience.2008.10.042.PMC 2649787.PMID 19017536.
  5. ^Maciejak P, Szyndler J, Turzyńska D, Sobolewska A, Taracha E, Skórzewska A, et al. (July 2009). "The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration".Brain Research.1282:20–7.doi:10.1016/j.brainres.2009.05.049.PMID 19481536.S2CID 20844494.
Group I
mGluR1Tooltip Metabotropic glutamate receptor 1
mGluR5Tooltip Metabotropic glutamate receptor 5
Group II
mGluR2Tooltip Metabotropic glutamate receptor 2
mGluR3Tooltip Metabotropic glutamate receptor 3
Group III
mGluR4Tooltip Metabotropic glutamate receptor 4
mGluR6Tooltip Metabotropic glutamate receptor 6
mGluR7Tooltip Metabotropic glutamate receptor 7
mGluR8Tooltip Metabotropic glutamate receptor 8
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