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| Names | |
|---|---|
| IUPAC name (2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-5- (diaminomethylideneamino)pentanoic acid | |
| Other names Kiotorphin L-Tyrosyl-L-arginine | |
| Identifiers | |
3D model (JSmol) | |
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| UNII | |
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| Properties | |
| C15H23N5O4 | |
| Molar mass | 337.380 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Kyotorphin (L-tyrosyl-L-arginine) is a neuroactivedipeptide which plays a role in pain regulation in the brain. It was first isolated from bovine brain, by Japanese scientists in 1979.[1] Kyotorphin was named for the site of its discovery,Kyoto, Japan and because of itsmorphine- (orendorphin-) like analgesic activity. Kyotorphin has ananalgesic effect, but it does not interact with theopioid receptors. Instead, it acts by releasingmet-enkephalin and stabilizing it from degradation.[2][3] It may also possess properties ofneuromediator/neuromodulator. It has been shown that kyotorphin is present in the humancerebrospinal fluid and that its concentration is lower in patients with persistent pain.[4]
