This enzyme belongs to the family oftransferases, to be specific, thetransaminases, that transfer nitrogenous groups. Thesystematic name of this enzyme class isL-kynurenine:2-oxoglutarate aminotransferase. Other names in common use includekynurenine transaminase (cyclizing),kynurenine 2-oxoglutarate transaminase,kynurenine aminotransferase, andL-kynurenine aminotransferase. This enzyme participates intryptophan metabolism. It employs onecofactor,pyridoxal phosphate.
KYAT1,AADAT (aka KYAT2), andKYAT3 are examples of enzymes of this class.GOT2 (aka KYAT4) is also believed to catalyze the above reaction.[2]
^Guidetti P, Amori L, Sapko MT, Okuno E, Schwarcz R (July 2007). "Mitochondrial aspartate aminotransferase: a third kynurenate-producing enzyme in the mammalian brain".Journal of Neurochemistry.102 (1):103–11.doi:10.1111/j.1471-4159.2007.04556.x.PMID17442055.S2CID20413002.
Wogulis M, Chew ER, Donohoue PD, Wilson DK (February 2008). "Identification of formyl kynurenine formamidase and kynurenine aminotransferase from Saccharomyces cerevisiae using crystallographic, bioinformatic and biochemical evidence".Biochemistry.47 (6):1608–21.doi:10.1021/bi701172v.PMID18205391.
