Thekeratinocyte growth factor (KGF), also known asFGF7, is agrowth factor present in theepithelialization-phase ofwound healing. In this phase,keratinocytes are covering the wound, forming theepithelium.
KGF is a small signaling molecule that binds tofibroblast growth factor receptor 2b (FGFR2b).[1] For signalling to occur, a dimer is required between two FGF:FGFR complexes that is linked together by a molecule of heparin.
There are 23 known FGFs, and 4FGF receptors. FGF:FGFR binding is complex and regulated by a variety of mechanisms in a tissue specific manner.
FGF10 is also known as "keratinocyte growth factor 2".[2]
