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KRT33A

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

KRT33A

Identifiers

Aliases

KRT33A, HA3I, Ha-3I, K33A, KRTHA3A, Krt1-3, hHa3-I, keratin 33A

External IDs

OMIM:602761;MGI:1919138;HomoloGene:135742;GeneCards:KRT33A;OMA:KRT33A - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q21.2	Start	41,346,092bp^[1]
Band	17q21.2	End	41,350,828bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 D	Start	99,902,021bp^[2]
Band	11\|11 D	End	99,907,038bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

testicle

mucosa of esophagus

left testis

right testis

skin of abdomen

vagina

skin of leg

minor salivary glands

right lung

ectocervix

Top expressed in

hair follicle

skin of back

dermis

skin of external ear

skin of abdomen

sexually immature organism

medial head of gastrocnemius muscle

conjunctival fornix

diencephalon

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	structural molecule activity
Cellular component	intermediate filament extracellular space cytosol
Biological process	keratinization cornification
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


3883


71888

Ensembl


ENSG00000261986 ENSG00000006059


ENSMUSG00000035592

UniProt


O76009


Q8K0Y2

RefSeq (mRNA)


NM_004138


NM_027983

RefSeq (protein)


NP_004129


NP_082259

Location (UCSC)

Chr 17: 41.35 – 41.35 Mb

Chr 11: 99.9 – 99.91 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Keratin, type I cuticular Ha3-I is aprotein that in humans is encoded by theKRT33Agene.^[5]^[6]^[7]

The protein encoded by this gene is a member of thekeratin gene family. It is one of thetype I hair keratin genes which areclustered in a region ofchromosome 17q21.2 and have the same direction of transcription. As a type I hair keratin, it is an acidic protein whichheterodimerizes withtype II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes,KRT33A (this gene) andKRT33B.^[7]

References

[edit]

^^a ^b ^cENSG00000006059 GRCh38: Ensembl release 89: ENSG00000261986, ENSG00000006059 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000035592 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Rogers MA, Schweizer J, Kreig T, Winter H (Nov 1995). "A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms".Mol Biol Rep.20 (3):155–61.doi:10.1007/BF00990548.PMID 7565656.S2CID 24487602.
^Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006)."New consensus nomenclature for mammalian keratins".J Cell Biol.174 (2):169–74.doi:10.1083/jcb.200603161.PMC 2064177.PMID 16831889.
^^a ^b"Entrez Gene: KRT33A keratin 33A".

Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins".J. Invest. Dermatol.101 (1 Suppl):56S–59S.doi:10.1111/1523-1747.ep12362635.PMID 7686952.
Ewing RM, Chu P, Elisma F, et al. (2007)."Large-scale mapping of human protein-protein interactions by mass spectrometry".Mol. Syst. Biol.3 (1): 89.doi:10.1038/msb4100134.PMC 1847948.PMID 17353931.
Rogers MA, Winter H, Langbein L, et al. (2005). "The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain".Differentiation.72 (9–10):527–40.doi:10.1111/j.1432-0436.2004.07209006.x.PMID 15617563.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Langbein L, Rogers MA, Winter H, et al. (1999)."The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle".J. Biol. Chem.274 (28):19874–84.doi:10.1074/jbc.274.28.19874.PMID 10391933.
Rogers MA, Winter H, Wolf C, et al. (1998)."Characterization of a 190-kilobase pair domain of human type I hair keratin genes".J. Biol. Chem.273 (41):26683–91.doi:10.1074/jbc.273.41.26683.PMID 9756910.

Proteins of thecytoskeleton

Human

Microfilaments
andABPs

Myofilament

Actins	A1 A2 B C1 G1 G2
Myosins	I MYO1A MYO1B MYO1C MYO1D MYO1E MYO1F MYO1G MYO1H) II MYH1 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYH9 MYH10 MYH11 MYH13 MYH14 MYH15 MYH16 III MYO3A MYO3B V MYO5A MYO5B MYO5C VI MYO6 VII MYO7A MYO7B IX MYO9A MYO9B X MYO10 XV MYO15A XVIII MYO18A MYO18B LC MYL1 MYL2 MYL3 MYL4 MYL5 MYL6 MYL6B MYL7 MYL9 MYLIP MYLK MYLK2 MYLL1
Other	Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin Gelsolin Profilin 1 2 Titin

Other

Intermediate
filaments

Type 1/2
(Keratin,
Cytokeratin)

Epithelial keratins (soft alpha-keratins)	type I/chromosome 17 9 10 12 13 14 15 16 17 19 20 chromosome 12 18 none 21 type II/chromosome 12 1 2A 3 4 5 6A 6B 6C 7 8
Hair keratins (hard alpha-keratins)	type I/chromosome 17 31 32 33A 33B 34 35 36 37 38 type II/chromosome 12 81 82 83 84 85 86
Ungrouped alpha	chromosome 17 23 24 25 26 27 28 39 40 chromosome 12 71 72 73 74 75 76 77 78 79 80
Not alpha	Beta-keratin

Type 3

Type 4

Type 5

Microtubules
andMAPs

Tubulins	TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 TUBB TUBB1 TUBB2A TUBB2B TUBB2C TUBB3 TUBB4 TUBB4Q TUBB6 TUBB8 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 TUBD1 TUBE1
MAPs	EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4
Kinesins	KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9 KIF11 KIF12 KIF13A KIF13B KIF14 KIF15 KIF16B KIF17 KIF18A KIF18B KIF19 KIF20A KIF20B KIF21A KIF21B KIF22 KIF23 KIF24 KIF25 KIF26A KIF26B KIF27 KIFC1 KIFC2 KIFC3
Dyneins	axonemal:DNAH1 DNAH2 DNAH3 DNAH5 DNAH6 DNAH7 DNAH8 DNAH9 DNAH10 DNAH11 DNAH12 DNAH13 DNAH14 DNAH17 DNAI1 DNAI2 DNALI1 DNAL1 DNAL4 cytoplasmic:DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3
Microtubule organising proteins	CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1
Microtubule severing proteins	Katanin Spastin
Other	Tau protein Dynactin DCTN1 Stathmin Tektin TEKT1 TEKT2 TEKT3 TEKT4 TEKT5 Dynamin DNM1 DNM2 DNM3