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KLK8

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens

KLK8
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

1NPM

Identifiers
AliasesKLK8, HNP, NP, NRPN, PRSS19, TADG14, kallikrein related peptidase 8
External IDsOMIM:605644;MGI:1343327;HomoloGene:21410;GeneCards:KLK8;OMA:KLK8 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for KLK8
Genomic location for KLK8
Band19q13.41Start50,996,007bp[1]
End51,002,711bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for KLK8
Genomic location for KLK8
Band7 B3|7 28.26 cMStart43,447,001bp[2]
End43,453,250bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of abdomen

  • skin of leg

  • testicle

  • right uterine tube

  • vagina

  • human penis

  • oral cavity

  • minor salivary glands

  • vulva

  • gonad
Top expressed in
  • lip

  • esophagus

  • superior surface of tongue

  • skin of external ear

  • vas deferens

  • embryo

  • embryo

  • epiblast

  • skin of abdomen

  • blood
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11202

259277

Ensembl

ENSG00000129455

ENSMUSG00000064023

UniProt

O60259

Q61955

RefSeq (mRNA)

NM_001281431
NM_007196
NM_144505
NM_144506
NM_144507

NM_008940
NM_001324398

RefSeq (protein)

NP_001268360
NP_009127
NP_653088
NP_653089
NP_653090

NP_001311327
NP_032966

Location (UCSC)Chr 19: 51 – 51 MbChr 7: 43.45 – 43.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kallikrein-8 is aprotein that in humans is encoded by theKLK8gene.[5][6][7][8][9]

Kallikreins are a subgroup ofserine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated incarcinogenesis and some have potential as novel cancer and other diseasebiomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19.Alternate splicing of this gene results in four transcript variants encoding four different isoforms. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer.[9]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000129455 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000064023 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Mitsui S, Tsuruoka N, Yamashiro K, Nakazato H, Yamaguchi N (March 1999)."A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain".European Journal of Biochemistry.260 (3):627–634.doi:10.1046/j.1432-1327.1999.00213.x.PMID 10102990.
  6. ^Yoshida S, Taniguchi M, Hirata A, Shiosaka S (June 1998). "Sequence analysis and expression of human neuropsin cDNA and gene".Gene.213 (1–2):9–16.doi:10.1016/S0378-1119(98)00232-7.PMID 9714609.
  7. ^Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, et al. (June 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins".Biological Chemistry.387 (6):637–641.doi:10.1515/BC.2006.082.PMID 16800724.S2CID 436200.
  8. ^Diamandis EP, Deperthes D, Lundwall Å (June 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005".Biological Chemistry.387 (6):635–824.doi:10.1515/BC.2006.081.PMID 16800723.S2CID 83910246.
  9. ^ab"Entrez Gene: KLK8 kallikrein-related peptidase 8".

Further reading

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External links

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