This gene encodes anuclear protein that has threezinc fingers at the end of itsC-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within theN-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-richcore promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly otherTATA box-less genes. Two transcript variants encoding the same protein have been found for this gene.[7]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Onyango P, Koritschoner NP, Patrito LC, Zenke M, Weith A (Feb 1998). "Assignment of the gene encoding the core promoter element binding protein (COPEB) to human chromosome 10p15 by somatic hybrid analysis and fluorescence in situ hybridization".Genomics.48 (1):143–4.doi:10.1006/geno.1997.5124.PMID9503030.
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Bayat A, Watson JS, Stanley JK, Ferguson MW, Ollier WE (Jun 2003). "Genetic susceptibility to dupuytren disease: association of Zf9 transcription factor gene".Plastic and Reconstructive Surgery.111 (7):2133–9.doi:10.1097/01.PRS.0000060531.98180.32.PMID12794452.S2CID22210744.
