Kruppel-like factor 13, also known asKLF13, is aprotein that in humans is encoded by theKLF13gene.[5][6][7]
There is some evidence forKLF13 having a role in obesity. A methylation site, cg07814318, within the firstintron ofKLF13 has been associated with obesity and orexigenic processes.[8]Ghrelin levels also positively correlated with methylation levels of cg07814318.[8] Moreover, expression levels ofKLF13 were decreased and increased in the brains of starved and obese mice, respectively.[8]
KLF13 belongs to a family oftranscription factors that contain 3 classicalzinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes.[5][9]
KLF13 was first described as theRANTES factor of late activatedT lymphocytes (RFLAT)-1.[7] It regulates the expression of thechemokine RANTES in T lymphocytes. It functions as a lynchpin, inducing a large enhancesome. KLF13 knock-out mice show a defect in lymphocyte survival as KLF13 is a regulator ofBcl-xL expression.[7][10][11][12][13][14][15]
^abcWiemerslage L, Islam R, van der Kamp C, Cao H, Olivo G, Ence-Eriksson F, Castillo S, Larsen AL, Bandstein M, Dahlberg LS, Perland E, Gustavsson V, Nilsson J, Vogel H, Schürmann A, Larsson EM, Rask-Andersen M, Benedict C, Schiöth HB (14 Feb 2017). "A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels".Int J Obes (Lond).43 (6):990–994.doi:10.1038/ijo.2017.43.PMID28194012.S2CID52835570.
^Scohy S, Gabant P, Van Reeth T, Hertveldt V, Drèze PL, Van Vooren P, Rivière M, Szpirer J, Szpirer C (Nov 2000). "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family".Genomics.70 (1):93–101.doi:10.1006/geno.2000.6362.PMID11087666.
Asano H, Li XS, Stamatoyannopoulos G (Jun 2000). "FKLF-2: a novel Krüppel-like transcriptional factor that activates globin and other erythroid lineage genes".Blood.95 (11):3578–84.doi:10.1182/blood.V95.11.3578.PMID10828046.
Scohy S, Gabant P, Van Reeth T, Hertveldt V, Drèze PL, Van Vooren P, Rivière M, Szpirer J, Szpirer C (Nov 2000). "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family".Genomics.70 (1):93–101.doi:10.1006/geno.2000.6362.PMID11087666.
Zhang P, Basu P, Redmond LC, Morris PE, Rupon JW, Ginder GD, Lloyd JA (2006). "A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element".Blood Cells, Molecules & Diseases.35 (2):227–35.doi:10.1016/j.bcmd.2005.04.009.PMID16023392.
