Movatterモバイル変換

[0]ホーム

Jump to content

KIF5B

Edit links

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

KIF5B

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
1BG2,1MKJ,2P4N,3J8X,3J8Y,4HNA,4LNU

Identifiers

Aliases

KIF5B, HEL-S-61, KINH, KNS, KNS1, UKHC, kinesin family member 5B

External IDs

OMIM:602809;MGI:1098268;HomoloGene:55829;GeneCards:KIF5B;OMA:KIF5B - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10p11.22	Start	32,009,015bp^[1]
Band	10p11.22	End	32,056,425bp^[1]

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)^[2]

Band	18 A1\|18 4.46 cM	Start	6,201,002bp^[2]
Band	18 A1\|18 4.46 cM	End	6,242,174bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

tail of epididymis

caput epididymis

optic nerve

corpus epididymis

mucosa of paranasal sinus

inferior ganglion of vagus nerve

visceral pleura

lower lobe of lung

internal globus pallidus

Skeletal muscle tissue of biceps brachii

Top expressed in

globus pallidus

lateral geniculate nucleus

atrioventricular valve

ventral tegmental area

pontine nuclei

epithelium of lens

lateral hypothalamus

deep cerebellar nuclei

seminal vesicula

epithelium of stomach

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	microtubule motor activity nucleotide binding microtubule binding protein binding plus-end-directed microtubule motor activity ATP binding JUN kinase binding cadherin binding microtubule lateral binding identical protein binding ATPase activity
Cellular component	vesicle membrane kinesin complex endocytic vesicle microtubule organizing center membrane-bounded organelle ciliary rootlet perinuclear region of cytoplasm neuron projection microtubule cytoskeleton axonal growth cone cytoplasm cytosol microtubule cytoskeleton phagocytic vesicle axon cytoplasm
Biological process	cytoskeleton-dependent intracellular transport plus-end-directed vesicle transport along microtubule cytoplasm organization vesicle transport along microtubule positive regulation of potassium ion transport regulation of membrane potential positive regulation of synaptic transmission, GABAergic axon guidance microtubule-based movement stress granule disassembly positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of intracellular protein transport positive regulation of voltage-gated sodium channel activity positive regulation of vesicle fusion centrosome localization brain development hippocampus development positive regulation of protein localization to plasma membrane cellular response to interferon-gamma anterograde axonal protein transport anterograde neuronal dense core vesicle transport retrograde neuronal dense core vesicle transport
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


3799


16573

Ensembl


ENSG00000170759


ENSMUSG00000006740

UniProt


P33176


Q61768

RefSeq (mRNA)


NM_004521


NM_008448

RefSeq (protein)


NP_004512


NP_032474

Location (UCSC)

Chr 10: 32.01 – 32.06 Mb

Chr 18: 6.2 – 6.24 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Kinesin family member 5B (KIF5B) is aprotein that in humans is encoded by theKIF5Bgene.^[5]^[6] It is part of thekinesin family ofmotor proteins.

Interactions

[edit]

KIF5B has been shown tointeract with:

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000170759 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000006740 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Navone F, Niclas J, Hom-Booher N, Sparks L, Bernstein HD, McCaffrey G, Vale RD (Jun 1992)."Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells".The Journal of Cell Biology.117 (6):1263–75.doi:10.1083/jcb.117.6.1263.PMC 2289507.PMID 1607388.
^"Entrez Gene: KIF5B kinesin family member 5B".
^^a ^b ^cDiefenbach RJ, Diefenbach E, Douglas MW, Cunningham AL (Dec 2002). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23".Biochemistry.41 (50):14906–15.doi:10.1021/bi026417u.PMID 12475239.
^^a ^bRahman A, Friedman DS, Goldstein LS (Jun 1998)."Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins".The Journal of Biological Chemistry.273 (25):15395–403.doi:10.1074/jbc.273.25.15395.PMID 9624122.
^^a ^bRahman A, Kamal A, Roberts EA, Goldstein LS (Sep 1999)."Defective kinesin heavy chain behavior in mouse kinesin light chain mutants".The Journal of Cell Biology.146 (6):1277–88.doi:10.1083/jcb.146.6.1277.PMC 2156125.PMID 10491391.
^Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T (Apr 2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein".Biochemistry.41 (17):5566–72.doi:10.1021/bi015946f.PMID 11969417.

External links

[edit]

Overview of all the structural information available in thePDB forUniProt:P33176 (Kinesin-1 heavy chain) at thePDBe-KB.

v t e PDB gallery
1bg2: HUMAN UBIQUITOUS KINESIN MOTOR DOMAIN 1mkj: Human Kinesin Motor Domain With Docked Neck Linker

Proteins of thecytoskeleton

Human

Microfilaments
andABPs

Myofilament

Actins	A1 A2 B C1 G1 G2
Myosins	I MYO1A MYO1B MYO1C MYO1D MYO1E MYO1F MYO1G MYO1H) II MYH1 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYH9 MYH10 MYH11 MYH13 MYH14 MYH15 MYH16 III MYO3A MYO3B V MYO5A MYO5B MYO5C VI MYO6 VII MYO7A MYO7B IX MYO9A MYO9B X MYO10 XV MYO15A XVIII MYO18A MYO18B LC MYL1 MYL2 MYL3 MYL4 MYL5 MYL6 MYL6B MYL7 MYL9 MYLIP MYLK MYLK2 MYLL1
Other	Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin Gelsolin Profilin 1 2 Titin

Other

Intermediate
filaments

Type 1/2
(Keratin,
Cytokeratin)

Epithelial keratins (soft alpha-keratins)	type I/chromosome 17 9 10 12 13 14 15 16 17 19 20 chromosome 12 18 none 21 type II/chromosome 12 1 2A 3 4 5 6A 6B 6C 7 8
Hair keratins (hard alpha-keratins)	type I/chromosome 17 31 32 33A 33B 34 35 36 37 38 type II/chromosome 12 81 82 83 84 85 86
Ungrouped alpha	chromosome 17 23 24 25 26 27 28 39 40 chromosome 12 71 72 73 74 75 76 77 78 79 80
Not alpha	Beta-keratin

Type 3

Type 4

Type 5

Microtubules
andMAPs

Tubulins	TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 TUBB TUBB1 TUBB2A TUBB2B TUBB2C TUBB3 TUBB4 TUBB4Q TUBB6 TUBB8 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 TUBD1 TUBE1
MAPs	EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4
Kinesins	KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9 KIF11 KIF12 KIF13A KIF13B KIF14 KIF15 KIF16B KIF17 KIF18A KIF18B KIF19 KIF20A KIF20B KIF21A KIF21B KIF22 KIF23 KIF24 KIF25 KIF26A KIF26B KIF27 KIFC1 KIFC2 KIFC3
Dyneins	axonemal:DNAH1 DNAH2 DNAH3 DNAH5 DNAH6 DNAH7 DNAH8 DNAH9 DNAH10 DNAH11 DNAH12 DNAH13 DNAH14 DNAH17 DNAI1 DNAI2 DNALI1 DNAL1 DNAL4 cytoplasmic:DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3
Microtubule organising proteins	CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1
Microtubule severing proteins	Katanin Spastin
Other	Tau protein Dynactin DCTN1 Stathmin Tektin TEKT1 TEKT2 TEKT3 TEKT4 TEKT5 Dynamin DNM1 DNM2 DNM3