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KIF20B

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From Wikipedia, the free encyclopedia

Motor protein found in humans

KIF20B

Identifiers

Aliases

KIF20B, CT90, KRMP1, MPHOSPH1, MPP-1, MPP1, kinesin family member 20B

External IDs

OMIM:605498;MGI:2444576;HomoloGene:9418;GeneCards:KIF20B;OMA:KIF20B - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10q23.31	Start	89,701,590bp^[1]
Band	10q23.31	End	89,774,939bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 C1	Start	34,899,761bp^[2]
Band	19\|19 C1	End	34,953,145bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

testicle

oocyte

secondary oocyte

gonad

ventricular zone

Achilles tendon

ganglionic eminence

trabecular bone

bone marrow cell

skin of thigh

Top expressed in

genital tubercle

tail of embryo

secondary oocyte

zygote

hand

ventricular zone

primary oocyte

spermatocyte

lumbar spinal ganglion

morula

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding microtubule motor activity protein homodimerization activity microtubule binding ATPase activity protein binding WW domain binding plus-end-directed microtubule motor activity ATP binding
Cellular component	cytoplasm centrosome mitotic spindle pole cell projection spindle pole contractile ring kinesin complex growth cone microtubule cytoskeleton spindle nucleoplasm microtubule organizing center mitotic spindle midzone axon midbody nucleolus spindle midzone perinuclear region of cytoplasm microtubule cytoskeleton nucleus
Biological process	positive regulation of intracellular protein transport neuron projection morphogenesis cell division positive regulation of cytokinesis positive regulation of neuron migration microtubule-based movement positive regulation of mitotic cytokinetic process neural tube closure protein localization to microtubule regulation of establishment of protein localization positive regulation of cell population proliferation regulation of neuron migration cell cycle regulation of establishment of cell polarity regulation of mitotic nuclear division
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


9585


240641

Ensembl


ENSG00000138182


ENSMUSG00000024795

UniProt


Q96Q89


Q80WE4

RefSeq (mRNA)


NM_016195 NM_001284259 NM_001382506


NM_183046 NM_001362434

RefSeq (protein)


NP_001271188 NP_057279 NP_001369435


NP_898867 NP_001349363

Location (UCSC)

Chr 10: 89.7 – 89.77 Mb

Chr 19: 34.9 – 34.95 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Kinesin family member 20B is aprotein that in humans is encoded by theKIF20Bgene.^[5]^[6]^[7]^[8]

Interactions

[edit]

KIF20B has been shown tointeract withPIN1.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000138182 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000024795 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Jan 1997)."Identification of novel M phase phosphoproteins by expression cloning".Mol Biol Cell.7 (9):1455–69.doi:10.1091/mbc.7.9.1455.PMC 275994.PMID 8885239.
^Westendorf JM, Rao PN, Gerace L (Feb 1994)."Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope".Proc Natl Acad Sci U S A.91 (2):714–8.Bibcode:1994PNAS...91..714W.doi:10.1073/pnas.91.2.714.PMC 43019.PMID 8290587.
^^a ^bKamimoto T, Zama T, Aoki R, Muro Y, Hagiwara M (Oct 2001)."Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1".J Biol Chem.276 (40):37520–8.doi:10.1074/jbc.M106207200.PMID 11470801.
^"Entrez Gene: MPHOSPH1 M-phase phosphoprotein 1".

Fritzler MJ, Kerfoot SM, Feasby TE, et al. (2000). "Autoantibodies from patients with idiopathic ataxia bind to M-phase phosphoprotein-1 (MPP1)".J. Investig. Med.48 (1):28–39.PMID 10695267.
Wiemann S, Weil B, Wellenreuther R, et al. (2001)."Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs".Genome Res.11 (3):422–35.doi:10.1101/gr.GR1547R.PMC 311072.PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Abaza A, Soleilhac JM, Westendorf J, et al. (2003)."M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis".J. Biol. Chem.278 (30):27844–52.doi:10.1074/jbc.M304522200.PMC 2652640.PMID 12740395.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004)."The DNA sequence and comparative analysis of human chromosome 10".Nature.429 (6990):375–81.Bibcode:2004Natur.429..375D.doi:10.1038/nature02462.PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.

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Proteins of thecytoskeleton

Human

Microfilaments
andABPs

Myofilament

Actins	A1 A2 B C1 G1 G2
Myosins	I MYO1A MYO1B MYO1C MYO1D MYO1E MYO1F MYO1G MYO1H) II MYH1 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYH9 MYH10 MYH11 MYH13 MYH14 MYH15 MYH16 III MYO3A MYO3B V MYO5A MYO5B MYO5C VI MYO6 VII MYO7A MYO7B IX MYO9A MYO9B X MYO10 XV MYO15A XVIII MYO18A MYO18B LC MYL1 MYL2 MYL3 MYL4 MYL5 MYL6 MYL6B MYL7 MYL9 MYLIP MYLK MYLK2 MYLL1
Other	Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin Gelsolin Profilin 1 2 Titin

Other

Intermediate
filaments

Type 1/2
(Keratin,
Cytokeratin)

Epithelial keratins (soft alpha-keratins)	type I/chromosome 17 9 10 12 13 14 15 16 17 19 20 chromosome 12 18 none 21 type II/chromosome 12 1 2A 3 4 5 6A 6B 6C 7 8
Hair keratins (hard alpha-keratins)	type I/chromosome 17 31 32 33A 33B 34 35 36 37 38 type II/chromosome 12 81 82 83 84 85 86
Ungrouped alpha	chromosome 17 23 24 25 26 27 28 39 40 chromosome 12 71 72 73 74 75 76 77 78 79 80
Not alpha	Beta-keratin

Type 3

Type 4

Type 5

Microtubules
andMAPs

Tubulins	TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 TUBB TUBB1 TUBB2A TUBB2B TUBB2C TUBB3 TUBB4 TUBB4Q TUBB6 TUBB8 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 TUBD1 TUBE1
MAPs	EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4
Kinesins	KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9 KIF11 KIF12 KIF13A KIF13B KIF14 KIF15 KIF16B KIF17 KIF18A KIF18B KIF19 KIF20A KIF20B KIF21A KIF21B KIF22 KIF23 KIF24 KIF25 KIF26A KIF26B KIF27 KIFC1 KIFC2 KIFC3
Dyneins	axonemal:DNAH1 DNAH2 DNAH3 DNAH5 DNAH6 DNAH7 DNAH8 DNAH9 DNAH10 DNAH11 DNAH12 DNAH13 DNAH14 DNAH17 DNAI1 DNAI2 DNALI1 DNAL1 DNAL4 cytoplasmic:DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3
Microtubule organising proteins	CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1
Microtubule severing proteins	Katanin Spastin
Other	Tau protein Dynactin DCTN1 Stathmin Tektin TEKT1 TEKT2 TEKT3 TEKT4 TEKT5 Dynamin DNM1 DNM2 DNM3

Catenins

Membrane

Other

Nonhuman

See also:cytoskeletal defects

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