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KCNK12

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

KCNK12

Identifiers

Aliases

KCNK12, K2p12.1, THIK-2, THIK2, potassium two pore domain channel subfamily K member 12

External IDs

OMIM:607366;MGI:2684043;HomoloGene:11107;GeneCards:KCNK12;OMA:KCNK12 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2p16.3	Start	47,509,290bp^[1]
Band	2p16.3	End	47,570,985bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17\|17 E4	Start	88,053,229bp^[2]
Band	17\|17 E4	End	88,105,422bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

olfactory bulb

trigeminal ganglion

spinal ganglia

inferior olivary nucleus

cerebellum

cerebellar cortex

cerebellar hemisphere

right hemisphere of cerebellum

sural nerve

primary visual cortex

Top expressed in

primary visual cortex

cerebellar cortex

superior frontal gyrus

embryo

granulocyte

dentate gyrus of hippocampal formation granule cell

neural layer of retina

anterior horn of spinal cord

olfactory bulb

hippocampus proper

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	potassium channel activity voltage-gated ion channel activity potassium ion leak channel activity
Cellular component	integral component of membrane membrane integral component of plasma membrane
Biological process	potassium ion transport regulation of ion transmembrane transport ion transport stabilization of membrane potential potassium ion transmembrane transport
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


56660


210741

Ensembl


ENSG00000184261


ENSMUSG00000050138

UniProt


Q9HB15


Q76M80

RefSeq (mRNA)


NM_022055


NM_199251

RefSeq (protein)


NP_071338


NP_954859

Location (UCSC)

Chr 2: 47.51 – 47.57 Mb

Chr 17: 88.05 – 88.11 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium channel, subfamily K, member 12, also known asKCNK12 is a humangene. Theprotein encoded by this gene, K_2P12.1, is apotassium channel containing two pore-forming P domains.^[5]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000184261 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000050138 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Rajan S, Wischmeyer E, Karschin C, Preisig-Müller R, Grzeschik KH, Daut J, Karschin A, Derst C (March 2001)."THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels".J. Biol. Chem.276 (10):7302–11.doi:10.1074/jbc.M008985200.PMID 11060316.

External links

[edit]

KCNK12+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

Membrane transport protein:ion channels (TC 1A)

Ca²⁺:Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺:Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺:Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻:Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺:Proton channel	HVCN1
M⁺:CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺:TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+solutes):Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm:Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin