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| ECHA InfoCard | 100.233.380 |
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| Formula | C26H27NO |
| Molar mass | 369.508 g·mol−1 |
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JWH-210 is ananalgesic chemical from thenaphthoylindole family, which acts as a potentcannabinoid agonist at both theCB1 andCB2 receptors, with Ki values of 0.46 nM at CB1 and 0.69 nM at CB2. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higherbinding affinity (i.e. lower Ki) at CB1 than both its 4-methyl and 4-n-propylhomologuesJWH-122 (CB1 Ki 0.69 nM) and JWH-182 (CB1 Ki 0.65 nM) respectively, and than the 4-methoxy compoundJWH-081 (CB1 Ki 1.2 nM).[4] It was discovered by and named afterJohn W. Huffman.
JWH-210 may be neurotoxic to animals when administered in high doses.[5]
In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-210 areSchedule I Controlled Substances.[6]
JWH-210 and JWH-122 were banned in Sweden on 1 October 2010 as hazardous goods harmful to health, after being identified as ingredients in "herbal"synthetic cannabis products.[7][8] The substances JWH-210, JWH-122 andJWH-203 were classified as illegal drugs by the Swedish government as of 1 September 2011.[9]
As of October 2015 JWH-210 is a controlled substance in China.[10]