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| Formula | C26H27NO |
| Molar mass | 369.508 g·mol−1 |
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JWH-149 is a syntheticcannabimimetic that was discovered byJohn W. Huffman. It is theN-pentyl analog ofJWH-148. It is a potent but only moderately selective ligand for theCB2 receptor, with a binding affinity ofKi = 0.73 ± 0.03 nM at this subtype, and more than six times selectivity over the CB1 subtype.[1]
In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-149 areSchedule I Controlled Substances.[2]
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