JWH-116

Legal status
Legal status	CA: Schedule II DE: NpSG (Industrial and scientific use only) UK: Class B US: Schedule I
Identifiers
IUPAC name (2-Ethyl-1-pentyl-1H-indol-3-yl)-1-naphthalenylmethanone
CAS Number	619294-64-3
ChemSpider	29341485
UNII	RKP962UAI3
CompTox Dashboard(EPA)	DTXSID60210966
Chemical and physical data
Formula	C26H27NO
Molar mass	369.508 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCCN1C2=CC=CC=C2C(=C1CC)C(=O)C3=CC=CC4=CC=CC=C43
InChI InChI=1S/C26H27NO/c1-3-5-10-18-27-23(4-2)25(22-15-8-9-17-24(22)27)26(28)21-16-11-13-19-12-6-7-14-20(19)21/h6-9,11-17H,3-5,10,18H2,1-2H3 Key:AQHPTHKEKSWGPO-UHFFFAOYSA-N

JWH-116 is a syntheticcannabinoid receptor ligand from thenaphthoylindole family. It is theindole 2-ethyl derivative of related compoundJWH-018. The binding affinity of JWH-116 for the CB₁ receptor is reported as K_i = 52 ± 5 nM.^[1]

In the United States, all CB₁ receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-116 areSchedule I Controlled Substances.^[2]

• JWH-018
• JWH-081

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