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JWH-116

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
JWH-116
Legal status
Legal status
Identifiers
  • (2-Ethyl-1-pentyl-1H-indol-3-yl)-1-naphthalenylmethanone
CAS Number
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC26H27NO
Molar mass369.508 g·mol−1
3D model (JSmol)
  • CCCCCN1C2=CC=CC=C2C(=C1CC)C(=O)C3=CC=CC4=CC=CC=C43
  • InChI=1S/C26H27NO/c1-3-5-10-18-27-23(4-2)25(22-15-8-9-17-24(22)27)26(28)21-16-11-13-19-12-6-7-14-20(19)21/h6-9,11-17H,3-5,10,18H2,1-2H3
  • Key:AQHPTHKEKSWGPO-UHFFFAOYSA-N

JWH-116 is a syntheticcannabinoid receptor ligand from thenaphthoylindole family. It is theindole 2-ethyl derivative of related compoundJWH-018. The binding affinity of JWH-116 for the CB1 receptor is reported as Ki = 52 ± 5 nM.[1]

In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-116 areSchedule I Controlled Substances.[2]

See also

[edit]

References

[edit]
  1. ^Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, et al. (February 2003). "3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor".Bioorganic & Medicinal Chemistry.11 (4):539–49.doi:10.1016/s0968-0896(02)00451-0.PMID 12538019.S2CID 29107765.
  2. ^21 U.S.C. § 812:Schedules of controlled substances
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