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| Formula | C26H27NO2 |
| Molar mass | 385.507 g·mol−1 |
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JWH-098 is a syntheticcannabinoid receptoragonist from thenaphthoylindole family. It is theindole 2-methyl derivative of a closely related compoundJWH-081, but has markedly different affinity for theCB1 andCB2 receptors. While JWH-081 is around tenfold selective for CB1 over CB2, in JWH-098 this is reversed, and it is around four times weaker than JWH-081 at CB1 while being six times more potent at CB2, giving it a slight selectivity for CB2 overall. This makes JWH-098 a good example of how methylation of the indole 2-position in the naphthoylindole series tends to increase CB2 affinity, but often at the expense of CB1 binding.[2]
In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-098 areSchedule I Controlled Substances.[3]
JWH-098 is illegal in Russia,[4] Sweden,[5] and the UK,[6] although it is unclear whether it has any history of human use.
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