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| Formula | C25H38O2 |
| Molar mass | 370.577 g·mol−1 |
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JWH-051 is ananalgesic drug which is acannabinoidagonist. Its chemical structure is closely related to that of the potent cannabinoid agonistHU-210, with the only difference being the removal of the hydroxyl group at position 1 of the aromatic ring. It was discovered and named afterJohn W. Huffman.
JWH-051 retains high affinity for theCB1receptor, but is a much stronger agonist forCB2, with aKi value of 14nM at CB2 vs 19nM at CB1.[2] It was one of the first CB2-selective ligands developed, although its selectivity for CB2 is modest compared to newer compounds such asHU-308.
It has similar effects to other cannabinoid agonists such assedation andanalgesia, but with a relatively strongantiinflammatory effect due to its strong activity at CB2.[3][4][5]
