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JTE-907

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
JTE-907
Legal status
Legal status
Identifiers
  • N-(benzo[1,3]dioxol-5-ylmethyl)-7-methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3-carboxamide
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
ECHA InfoCard100.209.196Edit this at Wikidata
Chemical and physical data
FormulaC24H26N2O6
Molar mass438.480 g·mol−1
3D model (JSmol)
  • c4c3OCOc3ccc4CNC(=O)c(cc2ccc1OC)c(=O)[nH]c2c1OCCCCC
  • InChI=1S/C24H26N2O6/c1-3-4-5-10-30-22-19(29-2)9-7-16-12-17(24(28)26-21(16)22)23(27)25-13-15-6-8-18-20(11-15)32-14-31-18/h6-9,11-12H,3-5,10,13-14H2,1-2H3,(H,25,27)(H,26,28)
  • Key:GRAJFFFXJYFVOC-UHFFFAOYSA-N
  (verify)

JTE-907 is a drug used in scientific research that acts as a selectiveCB2inverse agonist.[1][2] It hasantiinflammatory effects in animal studies,[3] thought to be mediated by an interaction between the CB2 receptor andIgE.[4]

See also

[edit]

References

[edit]
  1. ^Iwamura H, Suzuki H, Ueda Y, Kaya T, Inaba T (February 2001). "In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor".The Journal of Pharmacology and Experimental Therapeutics.296 (2):420–5.doi:10.1016/S0022-3565(24)38760-9.PMID 11160626.
  2. ^Raitio KH, Savinainen JR, Vepsäläinen J, Laitinen JT, Poso A, Järvinen T, Nevalainen T (March 2006). "Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists".Journal of Medicinal Chemistry.49 (6):2022–7.doi:10.1021/jm050879z.PMID 16539390.
  3. ^Ueda Y, Miyagawa N, Matsui T, Kaya T, Iwamura H (September 2005). "Involvement of cannabinoid CB(2) receptor-mediated response and efficacy of cannabinoid CB(2) receptor inverse agonist, JTE-907, in cutaneous inflammation in mice".European Journal of Pharmacology.520 (1–3):164–71.doi:10.1016/j.ejphar.2005.08.013.PMID 16153638.
  4. ^Ueda Y, Miyagawa N, Wakitani K (January 2007). "Involvement of cannabinoid CB2 receptors in the IgE-mediated triphasic cutaneous reaction in mice".Life Sciences.80 (5):414–9.doi:10.1016/j.lfs.2006.09.026.PMID 17055000.
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