Protein-coding gene in the species Homo sapiens
Junctional adhesion molecule B is aprotein that in humans is encoded by theJAM2 gene .[ 5] [ 6] [ 7] CD322 (cluster of differentiation 322).
Tight junctions represent one mode of cell-to-cell adhesion inendothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through theparacellular space . The protein encoded by thisimmunoglobulin superfamily gene member is localized in the tight junctions betweenhigh endothelial cells . It acts as an adhesive ligand for interacting with a variety ofimmune cell types and may play a role inlymphocyte homing to secondarylymphoid organs .[ 7]
It is purported to promote lymphocyte transendothelial migration.[ 8] cell polarity , by associating to cell polarity proteinPARD3 (PAR-3), together withJAM3 .[ 9]
JAM2 has been shown tointeract withPARD3 .[ 9]
It also interacts with theintegrin dimerVLA-4 (also called α4β1).[ 10]
^a b c GRCh38: Ensembl release 89: ENSG00000154721 –Ensembl , May 2017^a b c GRCm38: Ensembl release 89: ENSMUSG00000053062 –Ensembl , May 2017^ "Human PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ Palmeri D, van Zante A, Huang CC, Hemmerich S, Rosen SD (Aug 2000)."Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells" .J Biol Chem .275 (25):19139– 45.doi :10.1074/jbc.M003189200 PMID 10779521 . ^ Cunningham SA, Arrate MP, Rodriguez JM, Bjercke RJ, Vanderslice P, Morris AP, Brock TA (Nov 2000)."A novel protein with homology to the junctional adhesion molecule. Characterization of leukocyte interactions" .J Biol Chem .275 (44):34750– 6.doi :10.1074/jbc.M002718200 PMID 10945976 . ^a b "Entrez Gene: JAM2 junctional adhesion molecule 2" .^ Johnson-Léger CA, Aurrand-Lions M, Beltraminelli N, Fasel N, Imhof BA (October 2002)."Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration" .Blood .100 (7):2479– 86.doi :10.1182/blood-2001-11-0098 PMID 12239159 . ^a b Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D (October 2003)."The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity" .J. Cell Sci .116 (Pt 19):3879– 91.doi :10.1242/jcs.00704 PMID 12953056 . ^ Cunningham SA, Rodriguez JM, Arrate MP, Tran TM, Brock TA (August 2002)."JAM2 interacts with alpha4beta1. Facilitation by JAM3" .J. Biol. 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