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Isopropoxate

From Wikipedia, the free encyclopedia

Pharmaceutical compound
Isopropoxate
Identifiers
  • propan-2-yl 3-(1-phenylethyl)imidazole-4-carboxylate
CAS Number
PubChemCID
ChemSpider
UNII
Chemical and physical data
FormulaC15H18N2O2
Molar mass258.321 g·mol−1
3D model (JSmol)
  • CC(C)OC(=O)C1=CN=CN1C(C)C2=CC=CC=C2
  • InChI=1S/C15H18N2O2/c1-11(2)19-15(18)14-9-16-10-17(14)12(3)13-7-5-4-6-8-13/h4-12H,1-3H3
  • Key:SEKLTEXFLCQQIM-UHFFFAOYSA-N

Isopropoxate is ananesthetic drug related toetomidate, which has been sold as adesigner drug as an active ingredient ine-cigarette liquids marketed under names such asspace oil orkpods. While the relatedn-propyl esterpropoxate has been known since the 1970s, the isopropyl ester isopropoxate is a novel compound which was previously unknown prior to its detection as a designer drug in China in January 2024. It was added to the controlled drug list in China in July 2024, following which a number of other etomidate analogues have continued to appear.[1][2][3][4]

References

[edit]
  1. ^Cheung YT, Yeung CW, Yu KY, Lau CY, Tong HF, Chong YK (January 2025). "A recent increasing occurrence of etomidate and propoxate/isopropoxate misuse".Clinical Toxicology.63 (1):65–67.doi:10.1080/15563650.2024.2423834.PMID 39600244.
  2. ^Zhang X, Chen Y, Liu J, Wang M, Dai Y, Zhao K, et al. (July 2025). "Identification of a novel imidazole-derived GABA agonist isopropoxate: simultaneous detection and quantification of imidazole-derived analogs from human hairs in abused cases by LC-MS/MS".Forensic Toxicology.43 (2):190–205.doi:10.1007/s11419-024-00707-y.PMID 39668300.
  3. ^Cheung YT, Lau CY, Tseung JS, Yu KY, Cheung HN, Shek CC, et al. (August 2025). "Acquired 11β-Hydroxylase deficiency in etomidate and (Iso)propoxate abusers: A nascent endocrine condition".Steroids.220 109639.doi:10.1016/j.steroids.2025.109639.PMID 40451601.
  4. ^Substance details: Isopropoxate. UNODC, 2025
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