Isoliquiritigenin has been studied for its potential pharmacological properties, and ongoing research is exploring its use infood additives and therapeutic applications, although further studies are needed to evaluate its safety and potential target-organ toxicity.[2] It is also under preliminary research for potentialanti-inflammatory effects through multiple molecular pathways.[3] It has been studied for its effects onmelanoma cells, where it was found to modulate microRNA-301b and its target geneLRIG1 in experimental models.[4] It is under preliminary research for potential therapeutic effects against age-relatedneurodegenerative diseases by targeting multiple pathological mechanisms such asoxidative stress, neurotransmitter imbalance, andmitochondrial dysfunction.[5]
Isoliquiritigenin exhibits various biological activities but has low oralbioavailability (11.8%) in rats due to extensive metabolism in theliver andsmall intestine, resulting in high levels of its metabolites M1 and M2.[6]
^Lee, Yu Kyung; Chin, Young-Won; Bae, Jin-Kyung; Seo, Jun Su; Choi, Young Hee (2013). "Pharmacokinetics of isoliquiritigenin and its metabolites in rats: low bioavailability is primarily due to the hepatic and intestinal metabolism".Planta Medica.79 (17):1656–1665.Bibcode:2013PlMed..79.1656L.doi:10.1055/s-0033-1350924.ISSN1439-0221.PMID24108436.
^Cho, S; Kim, S; Jin, Z; Yang, H; Han, D; Baek, N. I.; Jo, J; Cho, C. W.; Park, J. H.; Shimizu, M; Jin, Y. H. (2011). "Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABAA receptors and shows hypnotic effects".Biochemical and Biophysical Research Communications.413 (4):637–42.doi:10.1016/j.bbrc.2011.09.026.PMID21945440.
