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Irampanel

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Irampanel
Clinical data
ATC code
  • None
Identifiers
  • N,N-Dimethyl-2-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenoxy]ethanamine
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC18H19N3O2
Molar mass309.369 g·mol−1
3D model (JSmol)
  • CN(C)CCOc1ccccc1c2nc(no2)c3ccccc3
  • InChI=1S/C18H19N3O2/c1-21(2)12-13-22-16-11-7-6-10-15(16)18-19-17(20-23-18)14-8-4-3-5-9-14/h3-11H,12-13H2,1-2H3
  • Key:QZULPCPLWGCGSL-UHFFFAOYSA-N

Irampanel (INN, code nameBIIR-561) is adrug which acts as a dualnoncompetitive antagonist of theAMPA receptor andneuronal voltage-gated sodium channel blocker.[1][2] It was under development byBoehringer Ingelheim for the treatment ofacute stroke/cerebral ischemia but never completed clinical trials for this indication.[3][4] Irampanel was also trialed, originally, for the treatment ofepilepsy andpain, but these indications, too, were abandoned,[1] and the drug was ultimately never marketed.

References

[edit]
  1. ^abFeigin V (June 2002). "Irampanel Boehringer Ingelheim".Current Opinion in Investigational Drugs.3 (6):908–910.PMID 12137411.
  2. ^Wang KK, Larner SF, Robinson G, Hayes RL (December 2006)."Neuroprotection targets after traumatic brain injury".Current Opinion in Neurology.19 (6):514–519.doi:10.1097/WCO.0b013e3280102b10.PMID 17102687.S2CID 28119069.
  3. ^Sharma SS, Kaundal RK (1 January 2007)."Targeting Molecular Pathways in Stroke". In Ray A, Gulati K (eds.).Current Trends in Pharmacology. I. K. International Pvt Ltd. pp. 321–.ISBN 978-81-88237-77-7.
  4. ^Weiser T (April 2005). "AMPA receptor antagonists for the treatment of stroke".Current Drug Targets. CNS and Neurological Disorders.4 (2):153–159.doi:10.2174/1568007053544129.PMID 15857300.
GABAergics
GABAARPAMs
GABA-T inhibitors
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Channel
modulators
Sodium blockers
Calcium blockers
Potassium openers
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Calcium
VDCCsTooltip Voltage-dependent calcium channels
Blockers
Activators
Potassium
VGKCsTooltip Voltage-gated potassium channels
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Blockers
Activators
KCaTooltip Calcium-activated potassium channel
Blockers
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K2PsTooltip Tandem pore domain potassium channel
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Sodium
VGSCsTooltip Voltage-gated sodium channels
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Chloride
CaCCsTooltip Calcium-activated chloride channel
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CFTRTooltip Cystic fibrosis transmembrane conductance regulator
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KARTooltip Kainate receptor
NMDARTooltip N-Methyl-D-aspartate receptor
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