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| Protein binding | <10% |
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| Formula | C12H18123IN |
| Molar mass | 299.278 g/mol |
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Iofetamine (iodine-123,123I), brand namesPerfusamine,SPECTamine), orN-isopropyl-(123I)-p-iodoamphetamine (IMP), is alipid-solubleamine andradiopharmaceuticaldrug used incerebral blood perfusion imaging withsingle-photon emission computed tomography (SPECT).[1][2][3] Labeled with theradioactiveisotopeiodine-123, it is approved for use in theUnited States as adiagnostic aid in determining the localization of and in the evaluation ofnon-lacunar stroke andcomplex partial seizures, as well as in the early diagnosis ofAlzheimer's disease.[1][2]
Ananalogue ofamphetamine, iofetamine has shown to inhibit the reuptake ofserotonin andnorepinephrine as well as induce the release of theseneurotransmitters and ofdopamine with similarpotencies to otheramphetamines liked-amphetamine andp-chloroamphetamine.[4][5] In addition, on account of its highlipophilicity, iofetamine rapidly penetrates theblood–brain barrier.[6] Accordingly, though not known to have been reported in themedical literature, iofetamine mightstimulant orentactogen effects. However, it might also beneurotoxic toserotonergic anddopaminergicneurons similarly to otherpara-halogenated amphetamines.[citation needed]
