| Intranodal palisaded myofibroblastoma | |
|---|---|
 | |
| Micrograph of an intranodal palisaded myofibroblastoma.H&E stain. | |
| Specialty | Oncology |
Intranodal palisaded myofibroblastoma (IPM) is a rare primary tumour oflymph nodes, that classically presents as aninguinal mass.[1]
It afflicts predominantly males of middle age.
IPMs present as painlesslymphadenopathy.[1] They usually are found in the inguinal region and grow slowly.The signs and symptoms are non-specific, i.e. it is not possible to diagnose an IPM from the symptoms and manner in which they present.[citation needed] The main (clinical) differential diagnosis of IPM ismetastaticcancer, e.g.squamous cell carcinoma,melanoma,adenocarcinoma.[citation needed]
IPMs are diagnosed by examination of thetissue by apathologist.[citation needed]They have a rim of peripherallymphoid tissue (remnant of alymph node) and consist of spindle cells withnuclearpalisading.Red blood cellextravasation is common andblood vessels surrounded bycollagen with (fine) peripheralspokes (amianthoid fibers) are usually seen.[2]
Immunostains forsmooth muscleactin andcyclin D1 are characteristically positive. The mainhistologicdifferential diagnosis isschwannoma.[citation needed]
Simple surgical excision is considered curative. Rare recurrences have been reported.[3]