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Interleukin 10 receptor, beta subunit

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

IL10RB

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
3LQM

Identifiers

Aliases

IL10RB, CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IL-10R2, Interleukin 10 receptor, beta subunit, interleukin 10 receptor subunit beta

External IDs

OMIM:123889;MGI:109380;HomoloGene:523;GeneCards:IL10RB;OMA:IL10RB - orthologs

Gene location (Human)

Chr.	Chromosome 21 (human)^[1]

Band	21q22.11	Start	33,266,367bp^[1]
Band	21q22.11	End	33,310,187bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16 C3.3\|16 52.87 cM	Start	91,203,052bp^[2]
Band	16 C3.3\|16 52.87 cM	End	91,222,722bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

placenta

monocyte

blood

granulocyte

mucosa of transverse colon

rectum

spleen

duodenum

appendix

gallbladder

Top expressed in

Ileal epithelium

adrenal gland

cardiac muscle tissue of left ventricle

stroma of bone marrow

interventricular septum

right ventricle

granulocyte

right lung lobe

choroid plexus of fourth ventricle

lumbar spinal ganglion

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding interleukin-10 receptor activity signaling receptor activity cytokine receptor activity
Cellular component	integral component of membrane interleukin-28 receptor complex membrane plasma membrane
Biological process	inflammatory response defense response to virus immune response signal transduction cytokine-mediated signaling pathway positive regulation of receptor signaling pathway via JAK-STAT
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


3588


16155

Ensembl


ENSG00000243646


ENSMUSG00000022969

UniProt


Q08334


Q61190

RefSeq (mRNA)


NM_000628


NM_008349

RefSeq (protein)


NP_000619


n/a

Location (UCSC)

Chr 21: 33.27 – 33.31 Mb

Chr 16: 91.2 – 91.22 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Interleukin 10 receptor, beta subunit is a subunit for theinterleukin-10 receptor.IL10RB is its humangene.^[5]

IL10RB has also been designatedCDw210b (cluster of differentiation w210b).

The protein encoded by this gene belongs to thecytokine receptor family. It is an accessory chain essential for the activeinterleukin 10 receptor complex. Coexpression of this andIL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes,IFNAR2,IFNAR1, andIFNGR2, form aclass II cytokine receptor gene cluster located in a small region on chromosome 21.^[5]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000243646 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000022969 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^b"Entrez Gene: IL10RB interleukin 10 receptor, beta".

Lutfalla G, McInnis MG, Antonarakis SE, Uzé G (1995). "Structure of the human CRFB4 gene: comparison with its IFNAR neighbor".J. Mol. Evol.41 (3):338–44.doi:10.1007/BF01215180.PMID 7563119.S2CID 38574595.
Lutfalla G, Gardiner K, Uzé G (1993). "A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR".Genomics.16 (2):366–73.doi:10.1006/geno.1993.1199.PMID 8314576.
Gibbs VC, Pennica D (1997). "CRF2-4: isolation of cDNA clones encoding the human and mouse proteins".Gene.186 (1):97–101.doi:10.1016/S0378-1119(96)00690-7.PMID 9047351.
Kotenko SV, Krause CD, Izotova LS, et al. (1997)."Identification and functional characterization of a second chain of the interleukin-10 receptor complex".EMBO J.16 (19):5894–903.doi:10.1093/emboj/16.19.5894.PMC 1170220.PMID 9312047.
Spencer SD, Di Marco F, Hooley J, et al. (1998)."The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor".J. Exp. Med.187 (4):571–8.doi:10.1084/jem.187.4.571.PMC 2212143.PMID 9463407.
Reboul J, Gardiner K, Monneron D, et al. (1999)."Comparative genomic analysis of the interferon/interleukin-10 receptor gene cluster".Genome Res.9 (3):242–50.doi:10.1101/gr.9.3.242.PMC 310731.PMID 10077530.
Hattori M, Fujiyama A, Taylor TD, et al. (2000)."The DNA sequence of human chromosome 21".Nature.405 (6784):311–9.Bibcode:2000Natur.405..311H.doi:10.1038/35012518.PMID 10830953.
Xie MH, Aggarwal S, Ho WH, et al. (2000)."Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R".J. Biol. Chem.275 (40):31335–9.doi:10.1074/jbc.M005304200.PMID 10875937.
Dumoutier L, Van Roost E, Colau D, Renauld JC (2000)."Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor".Proc. Natl. Acad. Sci. U.S.A.97 (18):10144–9.Bibcode:2000PNAS...9710144D.doi:10.1073/pnas.170291697.PMC 27764.PMID 10954742.
Lewis K, Li C, Perrin MH, et al. (2001)."Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor".Proc. Natl. Acad. Sci. U.S.A.98 (13):7570–5.Bibcode:2001PNAS...98.7570L.doi:10.1073/pnas.121165198.PMC 34709.PMID 11416224.
Hollborn M, Kohen L, Wiedemann P, Enzmann V (2001). "The influence of pro-inflammatory cytokines on human retinal pigment epithelium cell receptors".Graefes Arch. Clin. Exp. Ophthalmol.239 (4):294–301.doi:10.1007/s004170100263.PMID 11450494.S2CID 676836.
Josephson K, Logsdon NJ, Walter MR (2001)."Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site".Immunity.15 (1):35–46.doi:10.1016/S1074-7613(01)00169-8.PMID 11485736.
Sheppard P, Kindsvogel W, Xu W, et al. (2003). "IL-28, IL-29 and their class II cytokine receptor IL-28R".Nat. Immunol.4 (1):63–8.doi:10.1038/ni873.PMID 12469119.S2CID 35764259.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Kotenko SV, Gallagher G, Baurin VV, et al. (2003). "IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex".Nat. Immunol.4 (1):69–77.doi:10.1038/ni875.PMID 12483210.S2CID 2734534.
Hör S, Pirzer H, Dumoutier L, et al. (2004)."The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains".J. Biol. Chem.279 (32):33343–51.doi:10.1074/jbc.M405000200.PMID 15178681.
Zhang Z, Henzel WJ (2005)."Signal peptide prediction based on analysis of experimentally verified cleavage sites".Protein Sci.13 (10):2819–24.doi:10.1110/ps.04682504.PMC 2286551.PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Pletnev S, Magracheva E, Wlodawer A, Zdanov A (2006)."A model of the ternary complex of interleukin-10 with its soluble receptors".BMC Struct. Biol.5 10.doi:10.1186/1472-6807-5-10.PMC 1192808.PMID 15985167.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006)."Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes".Genome Res.16 (1):55–65.doi:10.1101/gr.4039406.PMC 1356129.PMID 16344560.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

v t e Proteins:clusters of differentiation (see alsolist of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 -CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 -CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Cytokine receptors

Chemokine receptor
(GPCRs)

CC	CCR1 /CCRL1 CCR2 CCRL2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCR10
CXC	IL-8 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CXCR7
Other	CX3C CX3CR1 XC XCR1 CCBP2 CMKLR1

TNF receptor

1-10	TNFR1(TNFRSF1A) TNFR2(TNFRSF1B) LTBR(TNFRSF3) CD134(TNFRSF4) CD40(TNFRSF5) Fas receptor(TNFRSF6) DcR3(TNFRSF6B) CD27(TNFRSF7) CD30(TNFRSF8) CD137(TNFRSF9)
11-20	DR4(TNFRSF10A) DR5(TNFRSF10B) DcR1(TNFRSF10C) DcR2(TNFRSF10D) RANK(TNFRSF11A) Osteoprotegerin(TNFRSF11B) TweakR(TNFRSF12A) TACI(TNFRSF13B) BAFFR(TNFRSF13C) HVEM(TNFRSF14) NGFR(TNFRSF16) BCMA(TNFRSF17) GITR(TNFRSF18) TAJ/TROY(TNFRSF19)
21-27	DR6(TNFRSF21) DR3(TNFRSF25) EDA2R(TNFRSF27)

JAK-STAT

Type I

γ-chain	Interleukin receptors IL2R /IL2RA/IL2RB /IL15R IL4R /IL13R /IL13RA1 /IL13RA2 IL7R /IL7RA IL9R IL21R
β-chain	Interleukin receptors IL3R /IL3RA IL5R /IL5RA GM-CSF
gp130	Interleukin receptors IL6RA 11/IL11RA 27/IL27RA OSMR LIFR CNTFR
IL12RB1	Interleukin receptors IL12R/IL12RB1/IL12RB2 IL23R
Other	otherCSF receptors EPO G-CSF Thrombopoietin hormone receptor:GH prolactin

Type II

Interleukin receptors
- IL10R /IL10RA /IL10RB /IL22R /IL22RA1 /IL22RA2
- IL20R /IL20RA /IL20RB
- IL28R
Interferon receptors
- -α/β /IFNAR1/IFNAR2
- -γ/IFNGR1 /IFNGR2

Ig superfamily

IL1
- IL1R1
- IL1R2
IL18R /IL18R1

IL 17 family

IL17

Enzyme-linked receptor

Interleukin receptor modulators

IL-1

Decoy receptors:Rilonacept (IL-1 Trap)

IL-2

IL-3

IL-4

Antagonists:Pitrakinra

Antibodies:Dupilumab
Pascolizumab

IL-5

Agonists:Interleukin 5

Antagonists:YM-90709

Antisense oligonucleotides:TPI ASM8

IL-6

Agonists:Atexakin alfa
Interleukin 6

IL-7

Agonists:Interleukin 7

IL-8

See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)here instead.

IL-9

Agonists:Interleukin 9

Antibodies:Enokizumab

IL-10

Agonists:Ilodecakin
Interleukin 10 (CSIF)

IL-11

Agonists:Interleukin 11 (AGIF)
Oprelvekin

IL-12

Agonists:Edodekin alfa
Interleukin 12

Antibodies:Briakinumab
Ustekinumab

IL-13

IL-15

Agonists:ALT-803
Interleukin 15

IL-17

Agonists:Interleukin 17 (A,B,C,D,E (interleukin 25),F)

IL-18

Binding proteins:IL18BP

IL-20

Antibodies:Fletikumab (against IL-20)

IL-21

Agonists:Denenicokin
Interleukin 21

Antibodies:NNC0114-0005
NNC0114-0006

IL-22

Agonists:Interleukin 22

Antibodies:Fezakinumab (against IL-22)

IL-23

Agonists:Interleukin 23 (SGRF)

IL-27

Agonists:Interleukin 27 (interleukin 30)

IL-28

IL-31

Agonists:Interleukin 31

IL1RL1

Agonists:Interleukin 33

IL1RL2

Agonists:Interleukin 36 (α,β,γ)
Interleukin 38

Antagonists:IL-36RA

Others

JAK	Seehere instead.
Others	Interleukin 14 (taxilin alpha, HMW-BCGF) Interleukin 16 (signals throughCD4) Interleukin 24 (signals throughIL-22Rα1/IL-20Rβ heterodimer) Interleukin 26 (signals throughIL-20Rα/IL-10Rβ heterodimer) Interleukin 32 Interleukin 34 (signals throughM-CSFR/CSF1R) Interleukin 35 Unsorted:Efavaleukin alfa Efineptakin alfa

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