| interleukin 3 receptor, alpha | |
|---|---|
| Identifiers | |
| Symbol | IL3RA |
| Alt. symbols | CD123 |
| HGNC | 6012 |
| OMIM | 308385 |
| Other data | |
| Locus | Chr. Xp22.3 |
| interleukin 3 receptor, Y-Chromosomal | |
|---|---|
| Identifiers | |
| Symbol | IL3RA |
| Alt. symbols | IL3RY, IL3RAY |
| NCBI gene | 3563 |
| HGNC | 6012 |
| OMIM | 430000 |
| Other data | |
| Locus | Chr. Yp11.3 |
Theinterleukin-3 receptor (CD123) is a molecule found on cells which helps transmit the signal ofinterleukin-3, a solublecytokine important in theimmune system.
Thegene coding for the receptor is located in thepseudoautosomal region of theX andY chromosomes.
The receptor belongs to thetype I cytokine receptor family and is aheterodimer with a unique alpha chain paired with thecommon beta (beta c or CD131) subunit.
The gene for the alpha subunit is 40kilobases long and has 12exons.
The receptor, found onpluripotent progenitor cells, inducestyrosinephosphorylation within the cell and promotes proliferation and differentiation within thehematopoietic cell lines. It can be found onbasophils andpDCs as well as somecDCs among peripheral blood mononuclear cells.
CD123 is expressed acrossacute myeloid leukemia (AML) subtypes, including leukemicstem cells.[1]
Tagraxofusp, human IL-3 fused to diphtheria toxin, is an approved treatment for BPDCN. An experimentalantibody-drug conjugate SGN-CD123A targets CD123 as a possible treatment for AML.[1]