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Interleukin-27 receptor

From Wikipedia, the free encyclopedia
Type I cytokine receptor for interleukin-27
interleukin 27 receptor, alpha
Identifiers
SymbolIL27RA
Alt. symbolsWSX-1, TCCR, CRL1, WSX1, zcytor1, IL-27R
NCBI gene9466
HGNC17290
OMIM605350
RefSeqNM_004843
UniProtQ6UWB1
Other data
LocusChr. 19p13.11
Search for
StructuresSwiss-model
DomainsInterPro
interleukin 6 signal transducer (gp130, oncostatin M receptor)
Identifiers
SymbolIL6ST
Alt. symbolsGP130, CD130
NCBI gene3572
HGNC6021
OMIM600694
RefSeqNM_002184
UniProtP40189
Other data
LocusChr. 5q11
Search for
StructuresSwiss-model
DomainsInterPro

Theinterleukin-27 receptor is atype I cytokine receptor forinterleukin-27. It is aheterodimer composed of theinterleukin 27 receptor, alpha subunit[1][2] andglycoprotein 130.[3]

IL27RA essential for transcriptional activation ofSTAT1 and for augmenting the induction ofT-bet expression during initiation ofTh1 cell differentiation.[4]

References

[edit]
  1. ^Sprecher CA, Grant FJ, Baumgartner JW, Presnell SR, Schrader SK, Yamagiwa T, Whitmore TE, O'Hara PJ, Foster DF (1998). "Cloning and characterization of a novel class I cytokine receptor".Biochem. Biophys. Res. Commun.246 (1):82–90.Bibcode:1998BBRC..246...82S.doi:10.1006/bbrc.1998.8576.PMID 9600072.
  2. ^Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS, de Sauvage FJ (2000). "Development of Th1-type immune responses requires the type I cytokine receptor TCCR".Nature.407 (6806):916–20.Bibcode:2000Natur.407..916C.doi:10.1038/35038103.PMID 11057672.S2CID 205009928.
  3. ^Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA (February 2004)."WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27".Journal of Immunology.172 (4):2225–31.doi:10.4049/jimmunol.172.4.2225.PMID 14764690.
  4. ^Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H (May 2003)."Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment".J. Immunol.170 (10):4886–90.doi:10.4049/jimmunol.170.10.4886.PMID 12734330.

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