 | |
| Names | |
|---|---|
| IUPAC name Inosine 5′-(tetrahydrogen triphosphate) | |
| Systematic IUPAC name O1-{[(2R,3S,4R,5R)-3,4-Dihydroxy-5-(6-oxo-1,6-dihydro-9H-purin-9-yl)oxolan-2-yl]methyl} tetrahydrogen triphosphate | |
| Other names iniosine triphosphate | |
| Identifiers | |
| |
3D model (JSmol) | |
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.004.589 |
| EC Number |
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| KEGG | |
| UNII | |
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| Properties | |
| C10H15N4O14P3 | |
| Molar mass | 508.165 g·mol−1 |
| 903.5 mg/mL | |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Inosine triphosphate (ITP) is an intermediate in thepurine metabolism pathway, seen in the synthesis ofATP andGTP. It comprises an inosinenucleotide containing three phosphate groups esterified to the sugarmoiety.
ITP results fromdeamination ofATP. Incorporation of ITP into the DNA from thenucleotide pool can lead to DNA damage, mutagenesis and other harmful effects.[1] ITP is processed by the enzymeinosine triphosphate pyrophosphatase (ITPA), which turns it intoinosine monophosphate (IMP), to avoid incorporation into DNA.[1]
