A biologist conducting research in a biotechnology laboratory
Biotechnology is a multidisciplinary field that involves the integration ofnatural sciences andengineering sciences in order to achieve the application of organisms and parts thereof for products and services.[1] Specialists in the field are known asbiotechnologists.
The termbiotechnology was first used byKároly Ereky in 1919[2] to refer to the production of products from raw materials with the aid of living organisms. The core principle of biotechnology involves harnessing biological systems and organisms, such as bacteria,yeast, and plants, to perform specific tasks or produce valuable substances.
Biotechnology had a significant impact on many areas of society, from medicine to agriculture toenvironmental science. One of the key techniques used in biotechnology isgenetic engineering, which allows scientists to modify the genetic makeup of organisms to achieve desired outcomes. This can involve inserting genes from one organism into another, and consequently, create new traits or modifying existing ones.[3]
Other important techniques used in biotechnology include tissue culture, which allows researchers to grow cells and tissues in the lab for research and medical purposes, andfermentation, which is used to produce a wide range of products such as beer, wine, and cheese.
The applications of biotechnology are diverse and have led to the development of products like life-saving drugs,biofuels, genetically modified crops, and innovative materials.[4] It has also been used to address environmental challenges, such as developing biodegradable plastics and using microorganisms to clean up contaminated sites.
Biotechnology is a rapidly evolving field with significant potential to address pressing global challenges and improve the quality of life for people around the world; however, despite its numerous benefits, it also poses ethical and societal challenges, such as questions aroundgenetic modification andintellectual property rights. As a result, there is ongoing debate and regulation surrounding the use and application of biotechnology in various industries and fields.[5]
Biotechnology encompasses a wide range of procedures formodifying livingorganisms for human purposes, going back todomestication of animals, cultivation of plants, and "improvements" to these through breeding programs that employ artificial selection andhybridization. Modern usage also includes genetic engineering, as well ascell andtissue culture technologies. TheAmerican Chemical Society definesbiotechnology as the application of biological organisms, systems, or processes by various industries to learning about thescience of life and the improvement of the value of materials and organisms, such as pharmaceuticals, crops, andlivestock.[6] As per theEuropean Federation of Biotechnology, biotechnology is the integration of natural science and organisms, cells, parts thereof, and molecular analogues for products and services.[7] Biotechnology is based on thebasicbiological sciences (e.g.,molecular biology,biochemistry,cell biology,embryology,genetics,microbiology) and conversely provides methods to support and perform basic research in biology.[citation needed]
Principles of Tissue Engineering
Biotechnology is theresearch and development in thelaboratory usingbioinformatics for exploration, extraction, exploitation, and production from anyliving organisms and any source ofbiomass by means ofbiochemical engineering where high value-added products could be planned (reproduced bybiosynthesis, for example), forecasted, formulated, developed, manufactured, and marketed for the purpose of sustainable operations (for the return from bottomless initial investment on R & D) and gaining durable patents rights (for exclusives rights for sales, and prior to this to receive national and international approval from the results on animal experiment and human experiment, especially on thepharmaceutical branch of biotechnology to prevent any undetected side-effects or safety concerns by using the products).[8][9][10] The utilization of biological processes,organisms or systems to produce products that are anticipated to improve human lives is termed biotechnology.[11]
By contrast,bioengineering is generally thought of as a related field that more heavily emphasizes higher systems approaches (not necessarily the altering or using of biological materialsdirectly) for interfacing with and utilizing living things. Bioengineering is the application of the principles ofengineering and natural sciences to tissues, cells, and molecules. This can be considered as the use of knowledge from working with and manipulating biology to achieve a result that can improve functions in plants and animals.[12] Relatedly,biomedical engineering is an overlapping field that often draws upon and appliesbiotechnology (by various definitions), especially in certain sub-fields of biomedical orchemical engineering such astissue engineering,biopharmaceutical engineering, andgenetic engineering.[citation needed]
Brewing was an early application of biotechnology.
Many forms of human-derivedagriculture fit the broad definition of "utilizing a biotechnological system to make products". The cultivation of plants may be viewed as the earliest biotechnological enterprise.[citation needed]
Agriculture has been theorized to have become the dominant way of producing food since theNeolithic Revolution. Through early biotechnology, the earliest farmers selected and bred the best-suited crops (e.g., those with the highest yields) to produce enough food to support a growing population. As crops and fields became increasingly large and difficult to maintain, it was discovered that specific organisms and their by-products could effectivelyfertilize,restore nitrogen, andcontrol pests. Throughout the history of agriculture, farmers have inadvertently altered the genetics of their crops through introducing them to new environments andbreeding them with other plants — one of the first forms of biotechnology.[clarification needed]
These processes also were included in early fermentation ofbeer.[13] These processes were introduced in earlyMesopotamia,Egypt,China andIndia, and still use the same basic biological methods. Inbrewing, malted grains (containingenzymes) convert starch from grains into sugar and then adding specificyeasts to produce beer. In this process,carbohydrates in the grains broke down into alcohols, such as ethanol. Later, other cultures produced the process oflactic acid fermentation, which produced other preserved foods, such assoy sauce. Fermentation was also used in this time period to produceleavened bread. Although the process of fermentation was not fully understood untilLouis Pasteur's work in 1857, it is still the first use of biotechnology to convert a food source into another form.[citation needed]
Before the time ofCharles Darwin's work and life, animal and plant scientists had already used selective breeding. Darwin added to that body of work with his scientific observations about the ability of science to change species. These accounts contributed to Darwin's theory of natural selection.[14]
For thousands of years, humans have used selective breeding to improve the production of crops and livestock to use them for food. In selective breeding, organisms with desirable characteristics are mated to produce offspring with the same characteristics. For example, this technique was used with corn to produce the largest and sweetest crops.[15]
Biotechnology has also led to the development of antibiotics. In 1928,Alexander Fleming discovered the moldPenicillium. His work led to the purification of the antibiotic formed by the mold byHoward Florey,Ernst Boris Chain andNorman Heatley – to form what we today know aspenicillin. In 1940, penicillin became available for medicinal use to treat bacterial infections in humans.[15]
The field of modern biotechnology is generally thought of as having been born in 1971 when Paul Berg's (Stanford) experiments in gene splicing had early success.Herbert W. Boyer (Univ. Calif. at San Francisco) andStanley N. Cohen (Stanford) significantly advanced the new technology in 1972 by transferring genetic material into a bacterium, such that the imported material would be reproduced. The commercial viability of a biotechnology industry was significantly expanded on June 16, 1980, when theUnited States Supreme Court ruled that agenetically modifiedmicroorganism could bepatented in the case ofDiamond v. Chakrabarty.[17] Indian-bornAnanda Chakrabarty, working forGeneral Electric, had modified a bacterium (of the genusPseudomonas) capable of breaking down crude oil, which he proposed to use in treating oil spills. (Chakrabarty's work did not involve gene manipulation but rather the transfer of entire organelles between strains of thePseudomonas bacterium).[citation needed]
A factor influencing the biotechnology sector's success is improved intellectual property rights legislation—and enforcement—worldwide, as well as strengthened demand for medical and pharmaceutical products.[30]
Rising demand for biofuels is expected to be good news for the biotechnology sector, with theDepartment of Energy estimatingethanol usage could reduce U.S. petroleum-derived fuel consumption by up to 30% by 2030. The biotechnology sector has allowed the U.S. farming industry to rapidly increase its supply of corn and soybeans—the main inputs into biofuels—by developing genetically modified seeds that resist pests and drought. By increasing farm productivity, biotechnology boosts biofuel production.[31]
Biotechnology has applications in four major industrial areas, including health care (medical), crop production and agriculture, non-food (industrial) uses of crops and other products (e.g.,biodegradable plastics,vegetable oil,biofuels), andenvironmental uses.[32]
For example, one application of biotechnology is the directed use ofmicroorganisms for the manufacture of organic products (examples includebeer andmilk products). Another example is using naturally presentbacteria by themining industry inbioleaching.[33] Biotechnology is also used to recycle, treat waste, clean up sites contaminated by industrial activities (bioremediation), and also to producebiological weapons.
A series of derived terms have been coined to identify several branches of biotechnology, for example:
Bioinformatics (or "gold biotechnology") is an interdisciplinary field that addresses biological problems using computational techniques, and makes the rapid organization as well as analysis of biological data possible. The field may also be referred to ascomputational biology, and can be defined as, "conceptualizing biology in terms of molecules and then applying informatics techniques to understand and organize the information associated with these molecules, on a large scale".[34] Bioinformatics plays a key role in various areas, such asfunctional genomics,structural genomics, andproteomics, and forms a key component in the biotechnology and pharmaceutical sector.[35]
Blue biotechnology is based on the exploitation of sea resources to create products and industrial applications.[36] This branch of biotechnology is the most used for the industries of refining and combustion principally on the production ofbio-oils with photosynthetic micro-algae.[36][37]
Green biotechnology is biotechnology applied to agricultural processes. An example would be the selection and domestication of plants viamicropropagation. Another example is the designing oftransgenic plants to grow under specific environments in the presence (or absence) of chemicals. One hope is that green biotechnology might produce more environmentally friendly solutions than traditionalindustrial agriculture. An example of this is the engineering of a plant to express apesticide, thereby ending the need of external application of pesticides. An example of this would beBt corn. Whether or not green biotechnology products such as this are ultimately more environmentally friendly is a topic of considerable debate.[36] It is commonly considered as the next phase of green revolution, which can be seen as a platform to eradicate world hunger by using technologies which enable the production of more fertile and resistant, towardsbiotic andabiotic stress, plants and ensures application of environmentally friendly fertilizers and the use of biopesticides, it is mainly focused on the development of agriculture.[36] On the other hand, some of the uses of green biotechnology involvemicroorganisms to clean and reduce waste.[38][36]
Red biotechnology is the use of biotechnology in the medical andpharmaceutical industries, and health preservation.[36] This branch involves the production ofvaccines andantibiotics, regenerative therapies, creation of artificial organs and new diagnostics of diseases.[36] As well as the development ofhormones,stem cells,antibodies, siRNA anddiagnostic tests.[36]
White biotechnology, also known as industrial biotechnology, is biotechnology applied toindustrial processes. An example is the designing of an organism to produce a useful chemical. Another example is the using ofenzymes as industrialcatalysts to either produce valuable chemicals or destroy hazardous/polluting chemicals. White biotechnology tends to consume less in resources than traditional processes used to produce industrial goods.[39][40]
Yellow biotechnology refers to the use of biotechnology in food production (food industry), for example in making wine (winemaking), cheese (cheesemaking), and beer (brewing) byfermentation.[36] It has also been used to refer to biotechnology applied to insects. This includes biotechnology-based approaches for the control of harmful insects, the characterisation and utilisation of active ingredients or genes of insects for research, or application in agriculture and medicine and various other approaches.[41]
Gray biotechnology is dedicated to environmental applications, and focused on the maintenance ofbiodiversity and the remotion of pollutants.[36]
Brown biotechnology is related to the management of arid lands anddeserts. One application is the creation of enhanced seeds that resist extremeenvironmental conditions of arid regions, which is related to the innovation, creation of agriculture techniques and management of resources.[36]
Violet biotechnology is related to law, ethical and philosophical issues around biotechnology.[36]
Microbial biotechnology has been proposed for the rapidly emerging area of biotechnology applications in space and microgravity (space bioeconomy)[42]
Dark biotechnology is the color associated withbioterrorism orbiological weapons and biowarfare which uses microorganisms, and toxins to cause diseases and death in humans, livestock and crops.[43][36]
In medicine, modern biotechnology has many applications in areas such aspharmaceutical drug discoveries and production,pharmacogenomics, and genetic testing (orgenetic screening). In 2021, nearly 40% of the total company value of pharmaceutical biotech companies worldwide were active inOncology withNeurology andRare Diseases being the other two big applications.[44]
DNA microarray chip – some can do as many as a million blood tests at once.
Pharmacogenomics (a combination ofpharmacology andgenomics) is the technology that analyses how genetic makeup affects an individual's response to drugs.[45] Researchers in the field investigate the influence ofgenetic variation on drug responses in patients by correlatinggene expression orsingle-nucleotide polymorphisms with a drug'sefficacy ortoxicity.[46] The purpose of pharmacogenomics is to develop rational means to optimize drug therapy, with respect to the patients'genotype, to ensure maximum efficacy with minimaladverse effects.[47] Such approaches promise the advent of "personalized medicine"; in which drugs and drug combinations are optimized for each individual's unique genetic makeup.[48][49]
Computer-generated image of insulin hexamers highlighting the threefoldsymmetry, thezinc ions holding it together, and thehistidine residues involved in zinc binding
Biotechnology has contributed to the discovery and manufacturing of traditionalsmall molecule pharmaceutical drugs as well as drugs that are the product of biotechnology –biopharmaceutics. Modern biotechnology can be used to manufacture existing medicines relatively easily and cheaply. The first genetically engineered products were medicines designed to treat human diseases. To cite one example, in 1978Genentech developed synthetic humanizedinsulin by joining its gene with aplasmid vector inserted into the bacteriumEscherichia coli. Insulin, widely used for the treatment of diabetes, was previously extracted from the pancreas ofabattoir animals (cattle or pigs). The genetically engineered bacteria are able to produce large quantities of synthetic human insulin at relatively low cost.[50][51] Biotechnology has also enabled emerging therapeutics likegene therapy. The application of biotechnology to basic science (for example through theHuman Genome Project) has also dramatically improved our understanding ofbiology and as our scientific knowledge of normal and disease biology has increased, our ability to develop new medicines to treat previously untreatable diseases has increased as well.[51]
Genetic testing allows thegeneticdiagnosis of vulnerabilities to inheriteddiseases, and can also be used to determine a child's parentage (genetic mother and father) or in general a person'sancestry. In addition to studyingchromosomes to the level of individual genes, genetic testing in a broader sense includesbiochemical tests for the possible presence of genetic diseases, or mutant forms of genes associated with increased risk of developing genetic disorders. Genetic testing identifies changes inchromosomes, genes, or proteins.[52] Most of the time, testing is used to find changes that are associated with inherited disorders. The results of a genetic test can confirm or rule out a suspected genetic condition or help determine a person's chance of developing or passing on agenetic disorder. As of 2011 several hundred genetic tests were in use.[53][54] Since genetic testing may open up ethical or psychological problems, genetic testing is often accompanied bygenetic counseling.
Genetically modified crops ("GM crops", or "biotech crops") are plants used inagriculture, theDNA of which has been modified withgenetic engineering techniques. In most cases, the main aim is to introduce a newtrait that does not occur naturally in the species. Biotechnology firms can contribute to future food security by improving the nutrition and viability of urban agriculture. Furthermore, the protection of intellectual property rights encourages private sector investment in agrobiotechnology.[55]
Examples in food crops include resistance to certain pests,[56] diseases,[57] stressful environmental conditions,[58] resistance to chemical treatments (e.g. resistance to aherbicide[59]), reduction of spoilage,[60] or improving the nutrient profile of the crop.[61] Examples in non-food crops include production ofpharmaceutical agents,[62]biofuels,[63] and other industrially useful goods,[64] as well as forbioremediation.[65][66]
Farmers have widely adopted GM technology. Between 1996 and 2011, the total surface area of land cultivated with GM crops had increased by a factor of 94, from 17,000 to 1,600,000 square kilometers (4,200,000 to 395,400,000 acres).[67] 10% of the world's crop lands were planted with GM crops in 2010.[67] As of 2011, 11 different transgenic crops were grown commercially on 395 million acres (160 million hectares) in 29 countries such as the US,Brazil,Argentina,India, Canada, China, Paraguay, Pakistan, South Africa, Uruguay, Bolivia, Australia, Philippines, Myanmar, Burkina Faso, Mexico, and Spain.[67]
Genetically modified foods are foods produced fromorganisms that have had specific changes introduced into theirDNA with the methods ofgenetic engineering. These techniques have allowed for the introduction of new crop traits as well as a far greater control over a food's genetic structure than previously afforded by methods such asselective breeding andmutation breeding.[68] Commercial sale of genetically modified foods began in 1994, whenCalgene first marketed itsFlavr Savr delayed ripening tomato.[69] To date most genetic modification of foods have primarily focused oncash crops in high demand by farmers such assoybean,corn,canola, andcotton seed oil. These have been engineered for resistance to pathogens and herbicides and better nutrient profiles. GM livestock have also been experimentally developed; in November 2013 none were available on the market,[70] but in 2015 the FDA approved the first GM salmon for commercial production and consumption.[71]
There is ascientific consensus[72][73][74][75] that currently available food derived from GM crops poses no greater risk to human health than conventional food,[76][77][78][79][80] but that each GM food needs to be tested on a case-by-case basis before introduction.[81][82][83] Nonetheless, members of the public are much less likely than scientists to perceive GM foods as safe.[84][85][86][87] The legal and regulatory status of GM foods varies by country, with some nations banning or restricting them, and others permitting them with widely differing degrees of regulation.[88][89][90][91]
GM crops also provide a number of ecological benefits, if not used in excess.[92] Insect-resistant crops have proven to lower pesticide usage, therefore reducing the environmental impact of pesticides as a whole.[93] However, opponents have objected to GM crops per se on several grounds, including environmental concerns, whether food produced from GM crops is safe, whether GM crops are needed to address the world's food needs, and economic concerns raised by the fact these organisms are subject to intellectual property law.
Biotechnology has several applications in the realm of food security. Crops likeGolden rice are engineered to have higher nutritional content, and there is potential for food products with longer shelf lives.[94] Though not a form of agricultural biotechnology, vaccines can help prevent diseases found in animal agriculture. Additionally, agricultural biotechnology can expedite breeding processes in order to yield faster results and provide greater quantities of food.[95] Transgenicbiofortification incereals has been considered as a promising method to combat malnutrition in India and other countries.[96]
Industrial biotechnology (known mainly in Europe as white biotechnology) is the application of biotechnology for industrial purposes, includingindustrial fermentation. It includes the practice of usingcells such asmicroorganisms, or components of cells likeenzymes, to generateindustrially useful products in sectors such as chemicals, food and feed, detergents, paper and pulp, textiles andbiofuels.[97] In the current decades, significant progress has been done in creatinggenetically modified organisms (GMOs) that enhance the diversity of applications and economical viability of industrial biotechnology. By using renewable raw materials to produce a variety of chemicals and fuels, industrial biotechnology is actively advancing towards lowering greenhouse gas emissions and moving away from a petrochemical-based economy.[98]
Synthetic biology is considered one of the essential cornerstones in industrial biotechnology due to its financial and sustainable contribution to the manufacturing sector. Jointly biotechnology and synthetic biology play a crucial role in generating cost-effective products withnature-friendly features by using bio-based production instead of fossil-based.[99] Synthetic biology can be used to engineermodel microorganisms, such asEscherichia coli, bygenome editing tools to enhance their ability to produce bio-based products, such asbioproduction of medicines andbiofuels.[100] For instance,E. coli andSaccharomyces cerevisiae in a consortium could be used as industrial microbes to produce precursors of thechemotherapeutic agentpaclitaxel by applying themetabolic engineering in a co-culture approach to exploit the benefits from the two microbes.[101]
Another example of synthetic biology applications in industrial biotechnology is the re-engineering of themetabolic pathways ofE. coli byCRISPR andCRISPRi systems toward the production of a chemical known as1,4-butanediol, which is used in fiber manufacturing. In order to produce 1,4-butanediol, the authors alter the metabolic regulation of theEscherichia coli by CRISPR to inducepoint mutation in thegltA gene,knockout of thesad gene, andknock-in six genes (cat1,sucD,4hbd,cat2,bld, andbdh). Whereas CRISPRi system used toknockdown the three competing genes (gabD,ybgC, andtesB) that affect the biosynthesis pathway of 1,4-butanediol. Consequently, the yield of 1,4-butanediol significantly increased from 0.9 to 1.8 g/L.[102]
Environmental biotechnology includes various disciplines that play an essential role in reducing environmental waste and providingenvironmentally safe processes, such asbiofiltration andbiodegradation.[103][104] The environment can be affected by biotechnologies, both positively and adversely. Vallero and others have argued that the difference between beneficial biotechnology (e.g.,bioremediation is to clean up an oil spill or hazard chemical leak) versus the adverse effects stemming from biotechnological enterprises (e.g., flow of genetic material from transgenic organisms into wild strains) can be seen as applications and implications, respectively.[105] Cleaning up environmental wastes is an example of an application ofenvironmental biotechnology; whereasloss of biodiversity or loss of containment of a harmful microbe are examples of environmental implications of biotechnology.[citation needed]
Many cities have installedCityTrees, which use biotechnology to filter pollutants from urban atmospheres.[106]
The regulation of genetic engineering concerns approaches taken by governments to assess and manage therisks associated with the use ofgenetic engineering technology, and the development and release of genetically modified organisms (GMO), includinggenetically modified crops andgenetically modified fish. There are differences in the regulation of GMOs between countries, with some of the most marked differences occurring between the US and Europe.[107][108] Regulation varies in a given country depending on the intended use of the products of the genetic engineering. For example, a crop not intended for food use is generally not reviewed by authorities responsible for food safety.[109] The European Union differentiates between approval for cultivation within the EU and approval for import and processing. While only a few GMOs have been approved for cultivation in the EU a number of GMOs have been approved for import and processing.[110] The cultivation of GMOs has triggered a debate about the coexistence of GM and non-GM crops. Depending on the coexistence regulations, incentives for the cultivation of GM crops differ.[111]
TheEUginius (European GMO Initiative for a Unified Database System) database is intended to help companies, interested private users and competent authorities to find precise information on the presence, detection and identification of GMOs used in theEuropean Union. The information is provided in English.[112]
In 1988, after prompting from theUnited States Congress, theNational Institute of General Medical Sciences (National Institutes of Health) (NIGMS) instituted a funding mechanism for biotechnology training. Universities nationwide compete for these funds to establish Biotechnology Training Programs (BTPs). Each successful application is generally funded for five years then must be competitively renewed.Graduate students in turn compete for acceptance into a BTP; if accepted, then stipend, tuition and health insurance support are provided for two or three years during the course of theirPhD thesis work. Nineteen institutions offer NIGMS supported BTPs.[113] Biotechnology training is also offered at the undergraduate level and in community colleges.[citation needed]
^SeeArnold JP (2005).Origin and History of Beer and Brewing: From Prehistoric Times to the Beginning of Brewing Science and Technology. Cleveland, Ohio: BeerBooks. p. 34.ISBN978-0-9662084-1-2.OCLC71834130..
^Cole-Turner R (2003)."Biotechnology".Encyclopedia of Science and Religion.Archived from the original on October 25, 2009. RetrievedDecember 7, 2014.
^abThieman WJ, Palladino MA (2008).Introduction to Biotechnology. Pearson/Benjamin Cummings.ISBN978-0-321-49145-9.
^Siam, R. (2009). Biotechnology Research and Development in Academia: providing the foundation for Egypt's Biotechnology spectrum of colors. Sixteenth Annual American University in Cairo Research Conference, American University in Cairo, Cairo, Egypt. BMC Proceedings, 31–35.
^Biotech: true colours. (2009). TCE: The Chemical Engineer, (816), 26–31.
^Aldridge, S. (2009). The four colours of biotechnology: the biotechnology sector is occasionally described as a rainbow, with each sub sector having its own colour. But what do the different colours of biotechnology have to offer the pharmaceutical industry. Pharmaceutical Technology Europe, (1). 12.
^Becquemont L (June 2009). "Pharmacogenomics of adverse drug reactions: practical applications and perspectives".Pharmacogenomics.10 (6):961–9.doi:10.2217/pgs.09.37.PMID19530963.
^Squassina A, Manchia M, Manolopoulos VG, Artac M, Lappa-Manakou C, Karkabouna S, Mitropoulos K, Del Zompo M, Patrinos GP (August 2010). "Realities and expectations of pharmacogenomics and personalized medicine: impact of translating genetic knowledge into clinical practice".Pharmacogenomics.11 (8):1149–67.doi:10.2217/pgs.10.97.PMID20712531.
^abU.S. Department of State International Information Programs, "Frequently Asked Questions About Biotechnology", USIS Online; available fromUSinfo.state.govArchived September 12, 2007, at theWayback Machine, accessed September 13, 2007. Cf.Feldbaum C (February 2002). "Biotechnology. Some history should be repeated".Science.295 (5557): 975.doi:10.1126/science.1069614.PMID11834802.S2CID32595222.
^"Definitions of Genetic Testing".Definitions of Genetic Testing (Jorge Sequeiros and Bárbara Guimarães). EuroGentest Network of Excellence Project. September 11, 2008. Archived fromthe original on February 4, 2009. RetrievedAugust 10, 2008.
^GM Science Review First ReportArchived October 16, 2013, at theWayback Machine, Prepared by the UK GM Science Review panel (July 2003). Chairman Professor Sir David King, Chief Scientific Advisor to the UK Government, P 9
^Nicolia, Alessandro; Manzo, Alberto; Veronesi, Fabio; Rosellini, Daniele (2013)."An overview of the last 10 years of genetically engineered crop safety research"(PDF).Critical Reviews in Biotechnology.34 (1):77–88.doi:10.3109/07388551.2013.823595.PMID24041244.S2CID9836802.Archived(PDF) from the original on October 9, 2022.We have reviewed the scientific literature on GE crop safety for the last 10 years that catches the scientific consensus matured since GE plants became widely cultivated worldwide, and we can conclude that the scientific research conducted so far has not detected any significant hazard directly connected with the use of GM crops.
The literature about Biodiversity and the GE food/feed consumption has sometimes resulted in animated debate regarding the suitability of the experimental designs, the choice of the statistical methods or the public accessibility of data. Such debate, even if positive and part of the natural process of review by the scientific community, has frequently been distorted by the media and often used politically and inappropriately in anti-GE crops campaigns.
^"State of Food and Agriculture 2003–2004. Agricultural Biotechnology: Meeting the Needs of the Poor. Health and environmental impacts of transgenic crops". Food and Agriculture Organization of the United Nations.Archived from the original on January 9, 2019. RetrievedAugust 30, 2019.Currently available transgenic crops and foods derived from them have been judged safe to eat and the methods used to test their safety have been deemed appropriate. These conclusions represent the consensus of the scientific evidence surveyed by the ICSU (2003) and they are consistent with the views of the World Health Organization (WHO, 2002). These foods have been assessed for increased risks to human health by several national regulatory authorities (inter alia, Argentina, Brazil, Canada, China, the United Kingdom and the United States) using their national food safety procedures (ICSU). To date no verifiable untoward toxic or nutritionally deleterious effects resulting from the consumption of foods derived from genetically modified crops have been discovered anywhere in the world (GM Science Review Panel). Many millions of people have consumed foods derived from GM plants – mainly maize, soybean and oilseed rape – without any observed adverse effects (ICSU).
^Ronald, Pamela (May 1, 2011)."Plant Genetics, Sustainable Agriculture and Global Food Security".Genetics.188 (1):11–20.doi:10.1534/genetics.111.128553.PMC3120150.PMID21546547.There is broad scientific consensus that genetically engineered crops currently on the market are safe to eat. After 14 years of cultivation and a cumulative total of 2 billion acres planted, no adverse health or environmental effects have resulted from commercialization of genetically engineered crops (Board on Agriculture and Natural Resources, Committee on Environmental Impacts Associated with Commercialization of Transgenic Plants, National Research Council and Division on Earth and Life Studies 2002). Both the U.S. National Research Council and the Joint Research Centre (the European Union's scientific and technical research laboratory and an integral part of the European Commission) have concluded that there is a comprehensive body of knowledge that adequately addresses the food safety issue of genetically engineered crops (Committee on Identifying and Assessing Unintended Effects of Genetically Engineered Foods on Human Health and National Research Council 2004; European Commission Joint Research Centre 2008). These and other recent reports conclude that the processes of genetic engineering and conventional breeding are no different in terms of unintended consequences to human health and the environment (European Commission Directorate-General for Research and Innovation 2010).
Domingo, José L.; Bordonaba, Jordi Giné (2011)."A literature review on the safety assessment of genetically modified plants"(PDF).Environment International.37 (4):734–742.Bibcode:2011EnInt..37..734D.doi:10.1016/j.envint.2011.01.003.PMID21296423.Archived(PDF) from the original on October 9, 2022.In spite of this, the number of studies specifically focused on safety assessment of GM plants is still limited. However, it is important to remark that for the first time, a certain equilibrium in the number of research groups suggesting, on the basis of their studies, that a number of varieties of GM products (mainly maize and soybeans) are as safe and nutritious as the respective conventional non-GM plant, and those raising still serious concerns, was observed. Moreover, it is worth mentioning that most of the studies demonstrating that GM foods are as nutritional and safe as those obtained by conventional breeding, have been performed by biotechnology companies or associates, which are also responsible of commercializing these GM plants. Anyhow, this represents a notable advance in comparison with the lack of studies published in recent years in scientific journals by those companies.
Krimsky, Sheldon (2015). "An Illusory Consensus behind GMO Health Assessment".Science, Technology, & Human Values.40 (6):883–914.doi:10.1177/0162243915598381.S2CID40855100.I began this article with the testimonials from respected scientists that there is literally no scientific controversy over the health effects of GMOs. My investigation into the scientific literature tells another story.
And contrast:
Panchin, Alexander Y.; Tuzhikov, Alexander I. (January 14, 2016). "Published GMO studies find no evidence of harm when corrected for multiple comparisons".Critical Reviews in Biotechnology.37 (2):213–217.doi:10.3109/07388551.2015.1130684.ISSN0738-8551.PMID26767435.S2CID11786594.Here, we show that a number of articles some of which have strongly and negatively influenced the public opinion on GM crops and even provoked political actions, such as GMO embargo, share common flaws in the statistical evaluation of the data. Having accounted for these flaws, we conclude that the data presented in these articles does not provide any substantial evidence of GMO harm.
The presented articles suggesting possible harm of GMOs received high public attention. However, despite their claims, they actually weaken the evidence for the harm and lack of substantial equivalency of studied GMOs. We emphasize that with over 1783 published articles on GMOs over the last 10 years it is expected that some of them should have reported undesired differences between GMOs and conventional crops even if no such differences exist in reality.
and
Yang, Y.T.; Chen, B. (2016). "Governing GMOs in the USA: science, law and public health".Journal of the Science of Food and Agriculture.96 (4):1851–1855.Bibcode:2016JSFA...96.1851Y.doi:10.1002/jsfa.7523.PMID26536836.It is therefore not surprising that efforts to require labeling and to ban GMOs have been a growing political issue in the USA(citing Domingo and Bordonaba, 2011). Overall, a broad scientific consensus holds that currently marketed GM food poses no greater risk than conventional food... Major national and international science and medical associations have stated that no adverse human health effects related to GMO food have been reported or substantiated in peer-reviewed literature to date.
Despite various concerns, today, the American Association for the Advancement of Science, the World Health Organization, and many independent international science organizations agree that GMOs are just as safe as other foods. Compared with conventional breeding techniques, genetic engineering is far more precise and, in most cases, less likely to create an unexpected outcome.
^"Statement by the AAAS Board of Directors On Labeling of Genetically Modified Foods"(PDF). American Association for the Advancement of Science. October 20, 2012.Archived(PDF) from the original on October 9, 2022. RetrievedAugust 30, 2019.The EU, for example, has invested more than €300 million in research on the biosafety of GMOs. Its recent report states: "The main conclusion to be drawn from the efforts of more than 130 research projects, covering a period of more than 25 years of research and involving more than 500 independent research groups, is that biotechnology, and in particular GMOs, are not per se more risky than e.g. conventional plant breeding technologies." The World Health Organization, the American Medical Association, the U.S. National Academy of Sciences, the British Royal Society, and every other respected organization that has examined the evidence has come to the same conclusion: consuming foods containing ingredients derived from GM crops is no riskier than consuming the same foods containing ingredients from crop plants modified by conventional plant improvement techniques.
^"Restrictions on Genetically Modified Organisms: United States. Public and Scholarly Opinion". Library of Congress. June 30, 2015.Archived from the original on December 30, 2019. RetrievedAugust 30, 2019.Several scientific organizations in the US have issued studies or statements regarding the safety of GMOs indicating that there is no evidence that GMOs present unique safety risks compared to conventionally bred products. These include the National Research Council, the American Association for the Advancement of Science, and the American Medical Association. Groups in the US opposed to GMOs include some environmental organizations, organic farming organizations, and consumer organizations. A substantial number of legal academics have criticized the US's approach to regulating GMOs.
^National Academies Of Sciences, Engineering; Division on Earth Life Studies; Board on Agriculture Natural Resources; Committee on Genetically Engineered Crops: Past Experience Future Prospects (2016).Genetically Engineered Crops: Experiences and Prospects. The National Academies of Sciences, Engineering, and Medicine (US). p. 149.doi:10.17226/23395.ISBN978-0-309-43738-7.PMID28230933.Archived from the original on November 16, 2021. RetrievedAugust 30, 2019.Overall finding on purported adverse effects on human health of foods derived from GE crops: On the basis of detailed examination of comparisons of currently commercialized GE with non-GE foods in compositional analysis, acute and chronic animal toxicity tests, long-term data on health of livestock fed GE foods, and human epidemiological data, the committee found no differences that implicate a higher risk to human health from GE foods than from their non-GE counterparts.
^"Frequently asked questions on genetically modified foods". World Health Organization.Archived from the original on November 4, 2020. RetrievedAugust 30, 2019.Different GM organisms include different genes inserted in different ways. This means that individual GM foods and their safety should be assessed on a case-by-case basis and that it is not possible to make general statements on the safety of all GM foods.
GM foods currently available on the international market have passed safety assessments and are not likely to present risks for human health. In addition, no effects on human health have been shown as a result of the consumption of such foods by the general population in the countries where they have been approved. Continuous application of safety assessments based on the Codex Alimentarius principles and, where appropriate, adequate post market monitoring, should form the basis for ensuring the safety of GM foods.
^Haslberger, Alexander G. (2003). "Codex guidelines for GM foods include the analysis of unintended effects".Nature Biotechnology.21 (7):739–741.doi:10.1038/nbt0703-739.PMID12833088.S2CID2533628.These principles dictate a case-by-case premarket assessment that includes an evaluation of both direct and unintended effects.
"Genetically modified foods and health: a second interim statement"(PDF). British Medical Association. March 2004.Archived(PDF) from the original on October 9, 2022. RetrievedAugust 30, 2019.In our view, the potential for GM foods to cause harmful health effects is very small and many of the concerns expressed apply with equal vigour to conventionally derived foods. However, safety concerns cannot, as yet, be dismissed completely on the basis of information currently available.
When seeking to optimise the balance between benefits and risks, it is prudent to err on the side of caution and, above all, learn from accumulating knowledge and experience. Any new technology such as genetic modification must be examined for possible benefits and risks to human health and the environment. As with all novel foods, safety assessments in relation to GM foods must be made on a case-by-case basis.
Members of the GM jury project were briefed on various aspects of genetic modification by a diverse group of acknowledged experts in the relevant subjects. The GM jury reached the conclusion that the sale of GM foods currently available should be halted and the moratorium on commercial growth of GM crops should be continued. These conclusions were based on the precautionary principle and lack of evidence of any benefit. The Jury expressed concern over the impact of GM crops on farming, the environment, food safety and other potential health effects.
The Royal Society review (2002) concluded that the risks to human health associated with the use of specific viral DNA sequences in GM plants are negligible, and while calling for caution in the introduction of potential allergens into food crops, stressed the absence of evidence that commercially available GM foods cause clinical allergic manifestations. The BMA shares the view that there is no robust evidence to prove that GM foods are unsafe but we endorse the call for further research and surveillance to provide convincing evidence of safety and benefit.
^Funk, Cary; Rainie, Lee (January 29, 2015)."Public and Scientists' Views on Science and Society". Pew Research Center.Archived from the original on January 9, 2019. RetrievedAugust 30, 2019.The largest differences between the public and the AAAS scientists are found in beliefs about the safety of eating genetically modified (GM) foods. Nearly nine-in-ten (88%) scientists say it is generally safe to eat GM foods compared with 37% of the general public, a difference of 51 percentage points.
^Kumar, Pankaj; Kumar, Arun; Dhiman, Karuna; Srivastava, Dinesh Kumar (2021), "Recent Progress in Cereals Biofortification to Alleviate Malnutrition in India: An Overview",Agricultural Biotechnology: Latest Research and Trends, Singapore: Springer Nature Singapore, pp. 253–280,doi:10.1007/978-981-16-2339-4_11,ISBN978-981-16-2338-7,S2CID245834290
^Wu, Meng-Ying; Sung, Li-Yu; Li, Hung; Huang, Chun-Hung; Hu, Yu-Chen (December 15, 2017). "Combining CRISPR and CRISPRi Systems for Metabolic Engineering of E. coli and 1,4-BDO Biosynthesis".ACS Synthetic Biology.6 (12):2350–2361.doi:10.1021/acssynbio.7b00251.ISSN2161-5063.PMID28854333.
^Wesseler J, Kalaitzandonakes N (2011). "Present and Future EU GMO policy". In Oskam A, Meesters G, Silvis H (eds.).EU Policy for Agriculture, Food and Rural Areas (2nd ed.). Wageningen: Wageningen Academic Publishers. pp. 23–332.
^Beckmann VC, Soregaroli J,Wesseler J (2011). "Coexistence of genetically modified (GM) and non-modified (non GM) crops: Are the two main property rights regimes equivalent with respect to the coexistence value?". In Carter C, Moschini G, Sheldon I (eds.).Genetically modified food and global welfare. Frontiers of Economics and Globalization Series. Vol. 10. Bingley, UK: Emerald Group Publishing. pp. 201–224.
